{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:41:38Z","timestamp":1778643698704,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Photochem Photobiol Sci"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1039\/c2pp05363b","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T14:00:40Z","timestamp":1327932040000},"page":"979-987","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterization and reactivity of photodimers of dihydroneopterin and dihydrobiopterin"],"prefix":"10.1007","volume":"11","author":[{"given":"Mariana","family":"Vignoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Lorente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco M.","family":"Cabrerizo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Erra-Balsells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Oliveros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s H.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,6,1]]},"reference":[{"key":"1106018_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/9780470186893","volume-title":"The Chemistry of Heterocyclic Compounds","author":"D J Brown","year":"1988","unstructured":"D. J. Brown, The Chemistry of Heterocyclic Compounds, John Wiley & Sons, New York, 1988, pp. 1\u201342."},{"key":"1106018_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4615-2960-6_1","volume-title":"Chemistry and Biology of Pteridines and Folates","author":"W Pfleiderer","year":"1993","unstructured":"W. Pfleiderer, Chemistry and Biology of Pteridines and Folates, Plenum Press, New York, 1993, pp. 1\u201316."},{"key":"1106018_CR3","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1021\/cr9402034","volume":"96","author":"T J Kappock","year":"1996","unstructured":"T. J. Kappock and J. P. Caradonna, Pterin-dependent amino acid hydroxylases Chem. Rev. 1996 96 2659\u20132756.","journal-title":"Chem. Rev."},{"key":"1106018_CR4","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1016\/S0021-9258(19)39752-2","volume":"265","author":"E R Werner","year":"1990","unstructured":"E. R. Werner, G. Werner-Felmayr, D. Fuchs, A. Hausen, G. Reibnegger, J. J. Yim, W. Pfleiderer and H. Wachter, Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1 and T24 cells. GTP-cyclohydrolase I is stimulated by interferon gamma, and 6-pyrovyl tetrahydropterin synthase and sepiapterinreductase are constitutively present J. Biol. Chem. 1990 265 3189\u20133192.","journal-title":"J. Biol. Chem."},{"key":"1106018_CR5","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1084\/jem.160.1.310","volume":"160","author":"C Huber","year":"1984","unstructured":"C. Huber, J. R. Batchelor, D. Fuchs, A. Hausen, A. Lang, D. Niederwieser, G. Reibnegger, P. Swetly, J. Troppmair and H. Wachter, Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma J. Exp. Med. 1984 160 310\u2013316.","journal-title":"J. Exp. Med."},{"key":"1106018_CR6","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.4049\/jimmunol.130.3.1047","volume":"130","author":"C Huber","year":"1983","unstructured":"C. Huber, D. Fuchs, A. Hausen, R. Margreiter, G. Reibnegger, M. Spielberger and H. Wachter, Pteridines as a new marker to detect human T cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants J. Immunol. 1983 130 1047\u20131050.","journal-title":"J. Immunol."},{"key":"1106018_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3109\/10408369209114604","volume":"29","author":"D Fuchs","year":"1992","unstructured":"D. Fuchs, G. Weiss and H. Wachter, The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases Crit. Rev. Clin. Lab. Sci. 1992 29 307\u2013341.","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"1106018_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000236491","volume":"101","author":"D Fuchs","year":"1993","unstructured":"D. Fuchs, G. Weiss and H. Wachter, Neopterin, biochemistry and clinical use as a marker for cellular immune reactions Int. Arch. Allergy Immunol. 1993 101 1\u20136.","journal-title":"Int. Arch. Allergy Immunol."},{"key":"1106018_CR9","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/0167-5699(88)91203-0","volume":"9","author":"D Fuchs","year":"1988","unstructured":"D. Fuchs, A. Hausen, G. Reibnegger, E. R. Werner, M. P. Dierich and H. Wachter, Neopterin as marker for activated cell mediated immunity Immunol. Today 1988 9 150\u2013155.","journal-title":"Immunol. Today"},{"key":"1106018_CR10","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1146\/annurev.bi.54.070185.003501","volume":"54","author":"C A Nichol","year":"1985","unstructured":"C. A. Nichol, G. K. Smith and D. S. Duch, Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin Annu. Rev. Biochem. 1985 54 729\u2013764.","journal-title":"Annu. Rev. Biochem."},{"key":"1106018_CR11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1006\/bbrc.1994.2423","volume":"204","author":"K U Schallreuter","year":"1994","unstructured":"K. U. Schallreuter, G. B\u00fcttner, M. R. Pittelkow, J. M. Wood, N. N. Swanson and C. Korner, Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin Biochem. Biophys. Res. Commun. 1994 204 43\u201348.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"1106018_CR12","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1046\/j.1523-1747.2001.00220.x","volume":"116","author":"K U Schallreuter","year":"2001","unstructured":"K. U. Schallreuter, J. Moore, J. M. Wood, W. D. Beazley, E. M. Peters, L. K. Marles, S. C. Behrens-Williams, R. Dummer, N. Blau, B. Th\u00f6ny, Epidermal H2O2 accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: Identification of a general mechanism in regulation of all 6BH4-dependent processes? J. Invest. Dermatol. 2001 116 167\u2013174.","journal-title":"J. Invest. Dermatol."},{"key":"1106018_CR13","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1126\/science.8128228","volume":"263","author":"K U Schallreuter","year":"1994","unstructured":"K. U. Schallreuter, J. M. Wood, M. R. Pittelkow, M. G\u00fctlich, K. R. Lemke, W. R\u00f6dl, N. N. Swanson, K. Hitzemann and I. Ziegler, Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin Science 1994 263 1444\u20131446.","journal-title":"Science"},{"key":"1106018_CR14","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1006\/bbrc.2002.6727","volume":"292","author":"H Rokos","year":"2002","unstructured":"H. Rokos, W. D. Beazley and K. U. Schallreuter, Oxidative stress in vitiligo: Photo-oxidation of pterins produces H2O2 and pterin-6-carboxylic acid Biochem. Biophys. Res. Commun. 2002 292 805\u2013811.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"1106018_CR15","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1039\/B209993D","volume":"2","author":"A H Thomas","year":"2003","unstructured":"A. H. Thomas, C. Lorente, A. L. Capparelli, C. G. Mart\u00ednez, A. M. Braun and E. Oliveros, Singlet oxygen (1?g) production by pterin derivatives in aqueous solutions Photochem. Photobiol. Sci. 2003 2 245\u2013250.","journal-title":"Photochem. Photobiol. Sci."},{"key":"1106018_CR16","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.freeradbiomed.2010.06.011","volume":"49","author":"M L D\u00e1ntola","year":"2010","unstructured":"M. L. D\u00e1ntola, M. Vignoni, C. Gonz\u00e1lez, C. Lorente, P. Vicendo, E. Oliveros and A. H. Thomas, Electron transfer processes induced by the triplet state of pterins in aqueous solutions Free Radical Biol. Med. 2010 49 1014\u20131022.","journal-title":"Free Radical Biol. Med."},{"key":"1106018_CR17","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1751-1097.2008.00450.x","volume":"85","author":"M Vignoni","year":"2009","unstructured":"M. Vignoni, F. M. Cabrerizo, C. Lorente and A. H. Thomas, New Results on the Photochemistry of Biopterin and Neopterin in Aqueous Solution Photochem. Photobiol. 2009 85 365\u2013373.","journal-title":"Photochem. Photobiol."},{"key":"1106018_CR18","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1021\/bi9620161","volume":"36","author":"K Ito","year":"1997","unstructured":"K. Ito and S. Kawanishi, Photoinduced hydroxylation of deoxyguanosine in DNA by pterins: Sequence specificity and mechanism Biochemistry 1997 36 1774\u20131781.","journal-title":"Biochemistry"},{"key":"1106018_CR19","doi-asserted-by":"publisher","first-page":"3001","DOI":"10.1021\/ja075367j","volume":"130","author":"G Petroselli","year":"2008","unstructured":"G. Petroselli, M. L. D\u00e1ntola, F. M. Cabrerizo, A. L. Capparelli, C. Lorente, E. Oliveros and A. H. Thomas, Oxidation of 2\u2019-Deoxyguanosine 5\u2019-Monophosphate Photoinduced by Pterin: Type I versus Type II Mechanism J. Am. Chem. Soc. 2008 130 3001\u20133011.","journal-title":"J. Am. Chem. Soc."},{"key":"1106018_CR20","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1039\/B913095K","volume":"8","author":"M Vignoni","year":"2010","unstructured":"M. Vignoni, F. M. Cabrerizo, C. Lorente, C. Claparols, E. Oliveros and A. H. Thomas, Photochemistry of dihydrobiopterin in aqueous solution Org. Biomol. Chem. 2010 8 800\u2013810.","journal-title":"Org. Biomol. Chem."},{"key":"1106018_CR21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1751-1097.2010.00833.x","volume":"87","author":"M Vignoni","year":"2011","unstructured":"M. Vignoni, M. P. Serrano, E. Oliveros and A. H. Thomas, Photodimerization of 7,8-dihydroneopterin in aqueous solution under UV-A irradiation Photochem. Photobiol. 2011 87 51\u201355.","journal-title":"Photochem. Photobiol."},{"key":"1106018_CR22","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1111\/j.1742-4658.2007.05761.x","volume":"274","author":"Y Wang","year":"2007","unstructured":"Y. Wang, Y. Li, Y. Wu and H. Yan, Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes FEBS J. 2007 274 2240\u20132252.","journal-title":"FEBS J."},{"key":"1106018_CR23","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jphotochem.2009.11.003","volume":"209","author":"M L D\u00e1ntola","year":"2010","unstructured":"M. L. D\u00e1ntola, A. H. Thomas, E. Oliveros and C. Lorente, Visible-light photochemistry of 6-formyl-7,8-dihydropterin in aqueous solution J. Photochem. Photobiol., A 2010 209 104\u2013110.","journal-title":"J. Photochem. Photobiol., A"},{"key":"1106018_CR24","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.cplett.2009.12.008","volume":"484","author":"M Vignoni","year":"2010","unstructured":"M. Vignoni, M. L. Salum, R. Erra-Balsells, A. H. Thomas and F. M. Cabrerizo, 1H NMR characterization of the intermediate formed upon UV-A excitation of biopterin, neopterin and 6-hydroxymethylpterin in O2-free aqueous solutions Chem. Phys. Lett. 2010 484 330\u2013332.","journal-title":"Chem. Phys. Lett."},{"key":"1106018_CR25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/j.1751-1097.1970.tb05991.x","volume":"11","author":"B H Jennings","year":"1970","unstructured":"B. H. Jennings, S. C. Pastra and J. L. Wellington, Photosensitized dimerization of thymine Photochem. Photobiol. 1970 11 215\u2013226.","journal-title":"Photochem. Photobiol."},{"key":"1106018_CR26","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/j.1751-1097.1972.tb06259.x","volume":"15","author":"B H Jennings","year":"1972","unstructured":"B. H. Jennings, S. Pastra-Landis and J. W. Lerman, Photosensitized dimerization of uracil Photochem. Photobiol. 1972 15 479\u2013491.","journal-title":"Photochem. Photobiol."},{"key":"1106018_CR27","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0021-9258(17)38244-3","volume":"253","author":"M Poe","year":"1978","unstructured":"M Poe and K. Hoogsteen, 5,6,7,8-tetrahydrofolic acid. Conformation of the tetrahydropyrazine ring J. Biol. Chem. 1978 253 543\u2013546.","journal-title":"J. Biol. Chem."},{"key":"1106018_CR28","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/mrc.1553","volume":"43","author":"A R Katritzky","year":"2005","unstructured":"A. R. Katritzky, N. G. Akhmedov, E. M. Myshakin, A. K. Verma and C. D. Hall, Low-temperature 1H and 13C NMR Spectra of N-Substituted 1,2,3,4-Tetrahydropyrazino[1,2-a]indoles Magn. Reson. Chem. 2005 43 351\u2013358.","journal-title":"Magn. Reson. Chem."},{"key":"1106018_CR29","volume-title":"Heterocyclic Chemistry","author":"T L Gilchrist","year":"1997","unstructured":"T. L. Gilchrist, Heterocyclic Chemistry, 3rd edn, Prentice Hall, 1997."}],"container-title":["Photochemical & Photobiological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1039\/c2pp05363b.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1039\/c2pp05363b\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2012\/PP\/C2PP05363B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1039\/c2pp05363b.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T04:15:21Z","timestamp":1686716121000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1039\/c2pp05363b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["1106018"],"URL":"https:\/\/doi.org\/10.1039\/c2pp05363b","relation":{},"ISSN":["1474-905X","1474-9092"],"issn-type":[{"value":"1474-905X","type":"print"},{"value":"1474-9092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"3 November 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}