{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:55:56Z","timestamp":1790484956138,"version":"4.1.0"},"reference-count":26,"publisher":"Royal Society of Chemistry (RSC)","issue":"40","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<p>\n                    There has been significant interest in the use of bioorthogonal inverse Diels\u2013Alder cycloadditions in molecular imaging. We have developed metal chelating tetrazine probes that extend tetrazine cycloadditions to the convenient and generator produced positron emitting isotope gallium-68 (\n                    <sup>68<\/sup>\n                    Ga).\n                  <\/p>","DOI":"10.1039\/c3cc49530b","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T11:33:15Z","timestamp":1392982395000},"page":"5215-5217","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["<sup>68<\/sup>\n                    Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers"],"prefix":"10.1039","volume":"50","author":[{"given":"Brandon","family":"Nichols","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California"},{"name":"San Diego"},{"name":"La Jolla, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtao","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Radiology"},{"name":"UCSD In Vivo Cancer and Molecular Imaging Center"},{"name":"University of California"},{"name":"San Diego"},{"name":"La Jolla, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California"},{"name":"San Diego"},{"name":"La Jolla, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Vera","sequence":"additional","affiliation":[{"name":"Department of Radiology"},{"name":"UCSD In Vivo Cancer and Molecular Imaging Center"},{"name":"University of California"},{"name":"San Diego"},{"name":"La Jolla, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal K.","family":"Devaraj","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California"},{"name":"San Diego"},{"name":"La Jolla, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2014]]},"reference":[{"key":"C3CC49530B-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrc882","volume":"2","author":"Gambhi","year":"2002","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"C3CC49530B-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1021\/bc900443a","volume":"21","author":"Ferreira","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"C3CC49530B-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s10585-012-9498-9","volume":"29","author":"Stroup","year":"2012","journal-title":"Clin. Exp. Metastasis"},{"key":"C3CC49530B-(cit4)\/*[position()=1]","first-page":"951","volume":"42","author":"Vera","year":"2001","journal-title":"J. Nucl. Med."},{"key":"C3CC49530B-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1002\/ange.200906294","volume":"122","author":"Rossin","year":"2010","journal-title":"Angew. Chem."},{"key":"C3CC49530B-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2967\/jnumed.112.115840","volume":"54","author":"Zeglis","year":"2013","journal-title":"J. Nucl. Med."},{"key":"C3CC49530B-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1073\/pnas.1113466109","volume":"109","author":"Devaraj","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"C3CC49530B-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2310\/7290.2012.00013","volume":"12","author":"Liu","year":"2013","journal-title":"Mol. Imaging"},{"issue":"17","key":"C3CC49530B-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1016\/j.bmcl.2011.04.116","volume":"21","author":"Selvaraj","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C3CC49530B-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8043","DOI":"10.1039\/c0cc03078c","volume":"46","author":"Li","year":"2010","journal-title":"Chem. Commun."},{"key":"C3CC49530B-(cit11)\/*[position()=1]","first-page":"2006","volume":"33","author":"Goodwin","year":"1992","journal-title":"J. Nucl. Med."},{"key":"C3CC49530B-(cit12)\/*[position()=1]","first-page":"265","volume":"19","author":"Thoren","year":"1978","journal-title":"Prog. Clin. Biol. Res."},{"key":"C3CC49530B-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1517\/17425247.2012.673580","volume":"9","author":"Varshosaz","year":"2012","journal-title":"Expert Opin. Drug Delivery"},{"key":"C3CC49530B-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1148\/radiol.12120638","volume":"265","author":"Emerson","year":"2012","journal-title":"Radiology"},{"key":"C3CC49530B-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1245\/s10434-006-9099-4","volume":"14","author":"Wallace","year":"2007","journal-title":"Ann. Surg. Oncol."},{"key":"C3CC49530B-(cit16)\/*[position()=1]","first-page":"159","volume":"29","author":"Torizuka","year":"1992","journal-title":"Kaku Igaku"},{"key":"C3CC49530B-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00006231-200102000-00013","volume":"22","author":"Qu","year":"2001","journal-title":"Nucl. Med. Commun."},{"key":"C3CC49530B-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00259-013-2397-8","volume":"40","author":"Haubner","year":"2013","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"3","key":"C3CC49530B-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1021\/bc900443a","volume":"21","author":"Ferreira","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"C3CC49530B-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1021\/bc300348d","volume":"23","author":"Ferreira","year":"2012","journal-title":"Bioconjugate Chem."},{"key":"C3CC49530B-(cit21)\/*[position()=1]","first-page":"1251","volume":"42","author":"Barendswaard","year":"2001","journal-title":"J. Nucl. Med."},{"key":"C3CC49530B-(cit22)\/*[position()=1]","first-page":"764","volume":"42","author":"Lee","year":"2001","journal-title":"J. Nucl. Med."},{"key":"C3CC49530B-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s00262-007-0433-x","volume":"57","author":"Ackerman","year":"2008","journal-title":"Cancer Immunol. Immunother."},{"key":"C3CC49530B-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1021\/ar200037t","volume":"44","author":"Devaraj","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"C3CC49530B-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1524\/ract.2011.1887","volume":"99","author":"Cutler","year":"2011","journal-title":"Radiochim. Acta"},{"key":"C3CC49530B-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7013","DOI":"10.1002\/anie.200903233","volume":"48","author":"Devaraj","year":"2009","journal-title":"Angew. Chem., Int. Ed."}],"container-title":["Chem. Commun."],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2014\/CC\/C3CC49530B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:12:34Z","timestamp":1782850354000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/50\/40\/5215-5217\/393010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":26,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1039\/c3cc49530b","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"This document is CrossCheck deposited","name":"crosscheck","explanation":{"URL":"http:\/\/www.crossref.org\/crosscheck\/index.html"},"group":{"name":"crosscheck","label":"CROSSCHECK"}},{"value":"Supplementary Information","URL":"http:\/\/dx.doi.org\/10.1039\/C3CC49530B","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Received 16 December 2013; Accepted 19 February 2014; Accepted Manuscript published 21 February 2014; Advance Article published 4 March 2014; Version of Record published 22 April 2014","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}