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Although radiation biomarkers have been reported in urine and serum, they are not informative about IR mediated tissue or organ specific injury. In the present study we report IR induced metabolic changes in gastrointestinal (GI) tissue of CD2F1 mice using ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight mass spectrometry. Post-radiation GI injury is a critical determinant of survival after exposure to IR. Our results show a distinct dose and time dependent response to GI tissue injury.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c3mb25454b","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T06:57:11Z","timestamp":1360738631000},"page":"723-731","source":"Crossref","is-referenced-by-count":27,"title":["Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model"],"prefix":"10.1093","volume":"9","author":[{"given":"Sanchita P","family":"Ghosh","sequence":"first","affiliation":[{"name":"Armed Forces Radiobiology Research Institute, USUHS a , Bethesda, MD, 20889-5603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajbir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Oncology, Georgetown University Medical Center b , Washington D.C., 20057, USA akc27@georgetown.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushal","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Armed Forces Radiobiology Research Institute, USUHS a , Bethesda, MD, 20889-5603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Armed Forces Radiobiology Research Institute, USUHS a , Bethesda, MD, 20889-5603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arushi","family":"Uppal","sequence":"additional","affiliation":[{"name":"Department of Oncology, Georgetown University Medical Center b , Washington D.C., 20057, USA akc27@georgetown.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Oncology, Georgetown University Medical Center b , Washington D.C., 20057, USA akc27@georgetown.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhjit","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Oncology, Georgetown University Medical Center b , Washington D.C., 20057, USA akc27@georgetown.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupak","family":"Pathak","sequence":"additional","affiliation":[{"name":"Division of Radiation Health, College of Pharmacy, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System c , Little Rock, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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