{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:17:26Z","timestamp":1791224246522,"version":"4.1.0"},"reference-count":53,"publisher":"Royal Society of Chemistry (RSC)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanoscale"],"published-print":{"date-parts":[[2013]]},"DOI":"10.1039\/c3nr02563b","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T07:30:35Z","timestamp":1372231835000},"page":"7897","source":"Crossref","is-referenced-by-count":46,"title":["Proper design of silica nanoparticles combines high brightness, lack of cytotoxicity and efficient cell endocytosis"],"prefix":"10.1039","volume":"5","author":[{"given":"Enrico","family":"Rampazzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Voltan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Petrizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelsi","family":"Zaccheroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Prodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Casciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Zauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Secchiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","reference":[{"key":"c3nr02563b-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1039\/b902711b","volume":"19","author":"Kim","year":"2009","journal-title":"J. Mater. Chem."},{"key":"c3nr02563b-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/anie.200802585","volume":"48","author":"Riehemann","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"c3nr02563b-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1002\/adfm.200901539","volume":"19","author":"Shi","year":"2009","journal-title":"Adv. Funct. Mater."},{"key":"c3nr02563b-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1021\/ar200054n","volume":"44","author":"Shi","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"c3nr02563b-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/cncr.22035","volume":"107","author":"Cuenca","year":"2006","journal-title":"Cancer"},{"key":"c3nr02563b-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1002\/adfm.200901538","volume":"19","author":"Doshi","year":"2009","journal-title":"Adv. Funct. Mater."},{"key":"c3nr02563b-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11523-009-0118-9","volume":"4","author":"Gunasekera","year":"2009","journal-title":"Target Oncol."},{"key":"c3nr02563b-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1039\/b817667c","volume":"19","author":"Yong","year":"2009","journal-title":"J. Mater. Chem."},{"key":"c3nr02563b-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.addr.2010.09.002","volume":"62","author":"Rai","year":"2010","journal-title":"Adv. Drug Delivery Rev."},{"key":"c3nr02563b-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jconrel.2010.04.004","volume":"146","author":"Kim","year":"2010","journal-title":"J. Controlled Release"},{"key":"c3nr02563b-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.phrs.2010.03.005","volume":"62","author":"Wang","year":"2010","journal-title":"Pharmacol. Res."},{"key":"c3nr02563b-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1039\/c0nr00156b","volume":"2","author":"Rosenholm","year":"2010","journal-title":"Nanoscale"},{"key":"c3nr02563b-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1172\/JCI45600","volume":"121","author":"Benezra","year":"2011","journal-title":"J. Clin. Invest."},{"key":"c3nr02563b-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1021\/cr2002596","volume":"112","author":"Mahmoudi","year":"2011","journal-title":"Chem. Rev."},{"key":"c3nr02563b-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1021\/cr300068p","volume":"112","author":"Reddy","year":"2012","journal-title":"Chem. Rev."},{"key":"c3nr02563b-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1039\/b411758a","volume":"29","author":"Prodi","year":"2005","journal-title":"New J. Chem."},{"key":"c3nr02563b-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1039\/b105959a","author":"Gong","year":"2001","journal-title":"Chem. Commun."},{"key":"c3nr02563b-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/310498a0","volume":"310","author":"Katz","year":"1984","journal-title":"Nature"},{"key":"c3nr02563b-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1460-9568.2010.07078.x","volume":"31","author":"Prilloff","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"c3nr02563b-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1039\/B600562B","volume":"35","author":"Burns","year":"2006","journal-title":"Chem. Soc. Rev."},{"key":"c3nr02563b-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nmat1390","volume":"4","author":"Medintz","year":"2005","journal-title":"Nat. Mater."},{"key":"c3nr02563b-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1039\/c2cc16306c","volume":"48","author":"Bae","year":"2012","journal-title":"Chem. Commun."},{"key":"c3nr02563b-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1021\/ac0693619","volume":"78","author":"Wang","year":"2006","journal-title":"Anal. Chem."},{"key":"c3nr02563b-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1002\/anie.201004996","volume":"50","author":"Bonacchi","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"c3nr02563b-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.ccr.2012.03.021","volume":"256","author":"Rampazzo","year":"2012","journal-title":"Coord. Chem. Rev."},{"key":"c3nr02563b-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1039\/C2NJ40673J","volume":"37","author":"Montalti","year":"2013","journal-title":"New J. Chem."},{"key":"c3nr02563b-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1021\/ar200018x","volume":"44","author":"Ambrogio","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"c3nr02563b-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14605","DOI":"10.1021\/jp1023444","volume":"114","author":"Rampazzo","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"c3nr02563b-(cit30)\/*[position()=1]","first-page":"4797","volume":"7","author":"Soster","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"c3nr02563b-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10975","DOI":"10.1039\/c1cc14800a","volume":"47","author":"Genovese","year":"2011","journal-title":"Chem. Commun."},{"key":"c3nr02563b-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13429","DOI":"10.1002\/chem.201101851","volume":"17","author":"Rampazzo","year":"2011","journal-title":"Chem.\u2013Eur. J."},{"key":"c3nr02563b-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1021\/nl0714637","volume":"7","author":"Ohulchanskyy","year":"2007","journal-title":"Nano Lett."},{"key":"c3nr02563b-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1039\/C1NR11401H","volume":"4","author":"Rampazzo","year":"2012","journal-title":"Nanoscale"},{"key":"c3nr02563b-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.taap.2012.06.002","volume":"263","author":"St\u0119pnik","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"c3nr02563b-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tiv.2012.09.002","volume":"27","author":"Berg","year":"2013","journal-title":"Toxicol. In Vitro"},{"key":"c3nr02563b-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bbagen.2010.04.007","volume":"1810","author":"Kunzmann","year":"2011","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"c3nr02563b-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1007\/s00216-012-6246-6","volume":"404","author":"Fede","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"c3nr02563b-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1039\/C1NR11269D","volume":"4","author":"Malvindi","year":"2012","journal-title":"Nanoscale"},{"key":"c3nr02563b-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.2147\/IJN.S34770","author":"Yeh","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"c3nr02563b-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/mt.2009.281","volume":"18","author":"Vercauteren","year":"2010","journal-title":"Mol. Ther."},{"key":"c3nr02563b-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"185101","DOI":"10.1088\/0957-4484\/24\/18\/185101","volume":"24","author":"Reno","year":"2013","journal-title":"Nanotechnology"},{"key":"c3nr02563b-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1039\/c2cs35031a","volume":"41","author":"Taylor","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"c3nr02563b-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1158\/1078-0432.CCR-11-1064","volume":"17","author":"Voltan","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"c3nr02563b-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1182\/blood-2004-10-4111","volume":"105","author":"Secchiero","year":"2005","journal-title":"Blood"},{"key":"c3nr02563b-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1365-2141.2012.09042.x","volume":"157","author":"Secchiero","year":"2012","journal-title":"Br. J. Haematol."},{"key":"c3nr02563b-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1007\/s11095-007-9310-8","volume":"24","author":"Voltan","year":"2007","journal-title":"Pharm. Res."},{"key":"c3nr02563b-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1158\/1078-0432.CCR-09-3031","volume":"16","author":"Secchiero","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"c3nr02563b-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1158\/1078-0432.CCR-10-2572","volume":"17","author":"Zauli","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"c3nr02563b-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1158\/1078-0432.CCR-10-3244","volume":"17","author":"Zauli","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"c3nr02563b-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e39543","DOI":"10.1371\/journal.pone.0039543","volume":"7","author":"Tisato","year":"2012","journal-title":"PLoS One"},{"key":"c3nr02563b-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.3324\/haematol.2012.062083","volume":"97","author":"Zauli","year":"2012","journal-title":"Haematologica"},{"key":"c3nr02563b-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000257339","volume":"47","author":"Candido","year":"2010","journal-title":"J. Vasc. Res."},{"key":"c3nr02563b-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1002\/jcp.22910","volume":"227","author":"Secchiero","year":"2012","journal-title":"J. Cell. Physiol."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2013\/NR\/C3NR02563B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:59:35Z","timestamp":1783533575000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/5\/17\/7897-7905\/407589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":53,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1039\/c3nr02563b","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}