{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:36:42Z","timestamp":1782934602895,"version":"3.54.5"},"reference-count":56,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<p>The theoretical model of drug screening method based on competitive reaction and fluorescence correlation spectroscopy.<\/p>","DOI":"10.1039\/c4an01816h","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T04:01:17Z","timestamp":1417752077000},"page":"1207-1214","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A sensitive and microscale method for drug screening combining affinity probes and single molecule fluorescence correlation spectroscopy"],"prefix":"10.1039","volume":"140","author":[{"given":"Lingao","family":"Ruan","sequence":"first","affiliation":[{"name":"College of Chemistry & Chemical Engineering"},{"name":"State Key Laboratory of Metal Matrix Composites"},{"name":"Shanghai Jiaotong University"},{"name":"Shanghai 200240"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Su","sequence":"additional","affiliation":[{"name":"College of Chemistry & Chemical Engineering"},{"name":"State Key Laboratory of Metal Matrix Composites"},{"name":"Shanghai Jiaotong University"},{"name":"Shanghai 200240"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Shao","sequence":"additional","affiliation":[{"name":"Shanghai Laiyi Center for Biopharmaceutical R&D"},{"name":"Shanghai 201203"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjie","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry & Chemical Engineering"},{"name":"State Key Laboratory of Metal Matrix Composites"},{"name":"Shanghai Jiaotong University"},{"name":"Shanghai 200240"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqing","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Chemistry & Chemical Engineering"},{"name":"State Key Laboratory of Metal Matrix Composites"},{"name":"Shanghai Jiaotong University"},{"name":"Shanghai 200240"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Chemistry & Chemical Engineering"},{"name":"State Key Laboratory of Metal Matrix Composites"},{"name":"Shanghai Jiaotong University"},{"name":"Shanghai 200240"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicun","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Chemistry & Chemical Engineering"},{"name":"State Key Laboratory of Metal Matrix Composites"},{"name":"Shanghai Jiaotong University"},{"name":"Shanghai 200240"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C4AN01816H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2012.09.019","volume":"64","author":"Lipinski","year":"2012","journal-title":"Adv. Drug Deliverery Rev."},{"key":"C4AN01816H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.1021\/ja1002263","volume":"132","author":"Veldkamp","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"C4AN01816H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.coph.2009.08.004","volume":"9","author":"Mayr","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"C4AN01816H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nrd3681","volume":"11","author":"Scannell","year":"2012","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C4AN01816H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1073\/pnas.1113324109","volume":"109","author":"Miller","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4AN01816H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1039\/c1lc20170k","volume":"11","author":"Carr","year":"2011","journal-title":"Lab Chip"},{"key":"C4AN01816H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.biomaterials.2010.09.026","volume":"32","author":"Wu","year":"2011","journal-title":"Biomaterials"},{"key":"C4AN01816H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/jms.525","volume":"38","author":"Reyzer","year":"2003","journal-title":"J. Mass Spectrom."},{"key":"C4AN01816H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13182","DOI":"10.1021\/ja106128u","volume":"132","author":"Zhao","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"C4AN01816H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrd748","volume":"1","author":"Pellecchia","year":"2002","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C4AN01816H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6902","DOI":"10.1021\/ac201458n","volume":"83","author":"Yuliana","year":"2011","journal-title":"Anal. Chem."},{"key":"C4AN01816H-(cit12)\/*[position()=1]","first-page":"1087057112460729","author":"Tsuganezawa","year":"2012","journal-title":"J. Biomol. Screening"},{"key":"C4AN01816H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/154065803322163759","volume":"1","author":"Loomans","year":"2003","journal-title":"Assay Drug Dev. Technol."},{"key":"C4AN01816H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nmeth1104","volume":"4","author":"Kim","year":"2007","journal-title":"Nat. Methods"},{"key":"C4AN01816H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.copbio.2006.06.012","volume":"17","author":"Boozer","year":"2006","journal-title":"Curr. Opin. Biotechnol."},{"key":"C4AN01816H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1021\/ac052030w","volume":"78","author":"Tang","year":"2006","journal-title":"Anal. Chem."},{"key":"C4AN01816H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ab.2010.12.025","volume":"411","author":"Zhao","year":"2011","journal-title":"Anal. Biochem."},{"key":"C4AN01816H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nmeth.1595","volume":"8","author":"McKenna","year":"2011","journal-title":"Nat. Methods"},{"key":"C4AN01816H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17528","DOI":"10.1021\/ja204301g","volume":"133","author":"Chang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C4AN01816H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17972","DOI":"10.1021\/ja3064588","volume":"134","author":"Shi","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"C4AN01816H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1021\/ac303624z","volume":"85","author":"Yi","year":"2013","journal-title":"Anal. Chem."},{"key":"C4AN01816H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nbt.1531","volume":"27","author":"Bachovchin","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"C4AN01816H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1103\/PhysRevLett.29.705","volume":"29","author":"Magde","year":"1972","journal-title":"Phys. Rev. Lett."},{"key":"C4AN01816H-(cit24)\/*[position()=1]","author":"Krieger","year":"2001","journal-title":"Fluorescence correlation spectroscopy"},{"key":"C4AN01816H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1093\/nar\/23.10.1795","volume":"23","author":"Kinjo","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"C4AN01816H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1016\/j.bpj.2011.11.012","volume":"101","author":"Elson","year":"2011","journal-title":"Biophys. J."},{"key":"C4AN01816H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12013-007-0042-5","volume":"49","author":"Hwang","year":"2007","journal-title":"Cell Biochem. Biophys."},{"key":"C4AN01816H-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0076-6879(10)72005-X","volume":"472","author":"Petr\u00e1\u0161ek","year":"2010","journal-title":"Methods Enzymol."},{"key":"C4AN01816H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cbpa.2014.04.006","volume":"20","author":"Singh","year":"2014","journal-title":"Curr. Opin. Chem. Biol."},{"key":"C4AN01816H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10627","DOI":"10.1364\/OE.18.010627","volume":"18","author":"Wohland","year":"2010","journal-title":"Opt. Express"},{"key":"C4AN01816H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1364\/OE.20.005243","volume":"20","author":"Leutenegger","year":"2012","journal-title":"Opt. Express"},{"key":"C4AN01816H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1021\/ja410284j","volume":"136","author":"Liu","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"C4AN01816H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0003-2697(02)00011-8","volume":"307","author":"Tetin","year":"2002","journal-title":"Anal. Biochem."},{"key":"C4AN01816H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.talanta.2009.05.013","volume":"79","author":"Xie","year":"2009","journal-title":"Talanta"},{"key":"C4AN01816H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ab.2007.07.018","volume":"370","author":"Fujii","year":"2007","journal-title":"Anal. Biochem."},{"key":"C4AN01816H-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1177\/1087057113492200","volume":"18","author":"Tsuganezawa","year":"2013","journal-title":"J. Biomol. Screening"},{"key":"C4AN01816H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/lpor.200910041","volume":"5","author":"M\u00fctze","year":"2011","journal-title":"Laser Photonics Rev."},{"key":"C4AN01816H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1016\/j.bmcl.2008.05.040","volume":"18","author":"Kawaguchi","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C4AN01816H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ab.2010.03.019","volume":"402","author":"Mikuni","year":"2010","journal-title":"Anal. Biochem."},{"key":"C4AN01816H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7350","DOI":"10.1021\/ac301654g","volume":"84","author":"Ruan","year":"2012","journal-title":"Anal. Chem."},{"key":"C4AN01816H-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1056\/NEJMoa055229","volume":"354","author":"Talpaz","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"C4AN01816H-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","volume":"344","author":"Druker","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"C4AN01816H-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm0596-561","volume":"2","author":"Druker","year":"1996","journal-title":"Nat. Med."},{"key":"C4AN01816H-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1056\/NEJMoa020461","volume":"347","author":"Demetri","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"C4AN01816H-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1056\/NEJMoa0912614","volume":"362","author":"Saglio","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"C4AN01816H-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1001\/jama.295.21.2516","volume":"295","author":"Motzer","year":"2006","journal-title":"J. Am. Med. Assoc."},{"key":"C4AN01816H-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1001\/jama.290.16.2149","volume":"290","author":"Kris","year":"2003","journal-title":"J. Am. Med. Assoc."},{"key":"C4AN01816H-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa050753","volume":"353","author":"Shepherd","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"C4AN01816H-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-5793(95)00062-E","volume":"360","author":"Wang","year":"1995","journal-title":"FEBS Lett."},{"key":"C4AN01816H-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0003-2697(04)00223-4","volume":"331","author":"Zhang","year":"2004","journal-title":"Anal. Biochem."},{"key":"C4AN01816H-(cit51)\/*[position()=1]","first-page":"899","volume":"33","author":"Zhang","year":"2005","journal-title":"Chinese J. Anal. Chem."},{"key":"C4AN01816H-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1021\/bi9819576","volume":"38","author":"Sch\u00fcler","year":"1999","journal-title":"Biochemistry"},{"key":"C4AN01816H-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nbt1358","volume":"26","author":"Karaman","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"C4AN01816H-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1038\/sj.bjc.6603170","volume":"94","author":"Weisberg","year":"2006","journal-title":"Br. J. Cancer"},{"key":"C4AN01816H-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1126\/science.289.5486.1938","volume":"289","author":"Schindler","year":"2000","journal-title":"Science"},{"key":"C4AN01816H-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nbt1068","volume":"23","author":"Fabian","year":"2005","journal-title":"Nat. Biotechnol."}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/AN\/C4AN01816H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:48:52Z","timestamp":1782928132000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/140\/4\/1207-1214\/424088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c4an01816h","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C4AN01816H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 9 October 2014; Accepted 4 December 2014;  Accepted Manuscript published 5 December 2014;  Advance Article published 19 December 2014;  Version of Record published 2 February 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}