{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:05:08Z","timestamp":1782882308853,"version":"3.54.5"},"reference-count":33,"publisher":"Royal Society of Chemistry (RSC)","issue":"64","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<p>Oligonucleotides modified with C5-amino acid LNA uridine result in highly thermostable duplexes, with excellent discrimination of single nucleotide mismatches. Additionally, these ONs are inert toward 3\u2032-exonuclease degradation.<\/p>","DOI":"10.1039\/c4cc03623a","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T07:01:08Z","timestamp":1402383668000},"page":"9007-9009","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["C5-Amino acid functionalized LNA: positively poised for antisense applications"],"prefix":"10.1039","volume":"50","author":[{"given":"Dale C.","family":"Guenther","sequence":"first","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Idaho"},{"name":"Moscow, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Idaho"},{"name":"Moscow, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke A.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Idaho"},{"name":"Moscow, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Hrdlicka","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Idaho"},{"name":"Moscow, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2014]]},"reference":[{"key":"C4CC03623A-(cit1a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1093\/nar\/25.22.4429","volume":"25","author":"Freier","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"C4CC03623A-(cit1b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.pharmtox.010909.105654","volume":"50","author":"Bennett","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"C4CC03623A-(cit1c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.chembiol.2012.07.011","volume":"19","author":"Deleavey","year":"2012","journal-title":"Chem. Biol."},{"key":"C4CC03623A-(cit2a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3987\/REV-10-667","volume":"81","author":"Obika","year":"2010","journal-title":"Heterocycles"},{"key":"C4CC03623A-(cit2b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1021\/cr100306q","volume":"112","author":"Zhou","year":"2012","journal-title":"Chem. Rev."},{"key":"C4CC03623A-(cit2c)\/*[position()=1]","volume-title":"Natural Products in Medicinal Chemistry","author":"Seth","year":"2014","unstructured":"P. P. Seth   and  E. E.Swayze , in  Natural Products in Medicinal Chemistry , ed.  S. Hanessian ,  Wiley-VCH ,  Weinheim , 1st edn,  2014 ,  pp. 403\u2013439"},{"key":"C4CC03623A-(cit3a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1039\/a708608c","author":"Singh","year":"1998","journal-title":"Chem. Commun."},{"key":"C4CC03623A-(cit3b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1016\/S0040-4039(98)01084-3","volume":"39","author":"Obika","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"C4CC03623A-(cit3c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1021\/cr050266u","volume":"107","author":"Kaur","year":"2007","journal-title":"Chem. Rev."},{"key":"C4CC03623A-(cit4a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1021\/ol401566r","volume":"15","author":"Hari","year":"2013","journal-title":"Org. Lett."},{"key":"C4CC03623A-(cit4b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1021\/ol401730d","volume":"15","author":"Migawa","year":"2013","journal-title":"Org. Lett."},{"key":"C4CC03623A-(cit4c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9064","DOI":"10.1021\/jo401170y","volume":"78","author":"Hanessian","year":"2013","journal-title":"J. Org. Chem."},{"key":"C4CC03623A-(cit4d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1039\/C3CC46017G","volume":"50","author":"Shrestha","year":"2014","journal-title":"Chem. Commun."},{"key":"C4CC03623A-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0223-5234(98)80016-0","volume":"33","author":"Luyten","year":"1998","journal-title":"Eur. J. Med. Chem."},{"key":"C4CC03623A-(cit5b)\/*[position()=1]","volume-title":"Modified Nucleosides in Biochemistry, Biotechnology and Medicine","author":"Ahmadian","year":"2008","unstructured":"M. Ahmadian   and  D. E.Bergstrom , in  Modified Nucleosides in Biochemistry, Biotechnology and Medicine , ed.  P. Herdewijn ,  Wiley-VCH ,  Weinheim , 1st edn,  2008 ,  pp. 251\u2013276"},{"key":"C4CC03623A-(cit6a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7128","DOI":"10.1021\/ja00069a009","volume":"115","author":"Hashimoto","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"C4CC03623A-(cit6b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1126\/science.7684856","volume":"260","author":"Wagner","year":"1993","journal-title":"Science"},{"key":"C4CC03623A-(cit6c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/bc00031a005","volume":"6","author":"Nara","year":"1995","journal-title":"Bioconjugate Chem."},{"key":"C4CC03623A-(cit6d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1093\/nar\/26.13.3127","volume":"26","author":"Ahmadian","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"C4CC03623A-(cit6e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12165","DOI":"10.1021\/ja982039y","volume":"120","author":"Heystek","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"C4CC03623A-(cit6f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1021\/ja029467v","volume":"125","author":"Roig","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"C4CC03623A-(cit6g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1021\/bi047561d","volume":"44","author":"Booth","year":"2005","journal-title":"Biochemistry"},{"key":"C4CC03623A-(cit6h)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1002\/chem.200306044","volume":"10","author":"Kottysch","year":"2004","journal-title":"Chem. \u2013 Eur. J."},{"key":"C4CC03623A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1021\/jo500614a","volume":"79","author":"Kumar","year":"2014","journal-title":"J. Org. Chem."},{"key":"C4CC03623A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"727","DOI":"10.2174\/156802607780487704","volume":"7","author":"Debart","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"C4CC03623A-(cit9a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/cbic.200500433","volume":"7","author":"Deglane","year":"2006","journal-title":"ChemBioChem"},{"key":"C4CC03623A-(cit9b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.bmcl.2008.02.063","volume":"18","author":"Park","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C4CC03623A-(cit9c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8404","DOI":"10.1021\/ja200312y","volume":"133","author":"Gagnon","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C4CC03623A-(cit10a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1039\/C0OB00532K","volume":"9","author":"Johannsen","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"C4CC03623A-(cit10b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1016\/j.bmc.2011.08.022","volume":"19","author":"Lietard","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"C4CC03623A-(cit10c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1039\/c1ob05469d","volume":"9","author":"Mori","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"C4CC03623A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1089\/154545703322860825","volume":"13","author":"Mergny","year":"2003","journal-title":"Oligonucleotides"},{"key":"C4CC03623A-(cit12)\/*[position()=1]","volume-title":"Handbook of Chemistry and Physics","year":"2006","unstructured":"Handbook of Chemistry and Physics , ed.  D. R. Lide ,  CRC Press ,  Boca Raton , 87th edn,  2006 ,  p. 7-1"}],"container-title":["Chem. Commun."],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2014\/CC\/C4CC03623A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:59:15Z","timestamp":1782878355000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/50\/64\/9007-9009\/427184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":33,"journal-issue":{"issue":"64","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1039\/c4cc03623a","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"This document is CrossCheck deposited","name":"crosscheck","explanation":{"URL":"http:\/\/www.crossref.org\/crosscheck\/index.html"},"group":{"name":"crosscheck","label":"CROSSCHECK"}},{"value":"Supplementary Information","URL":"http:\/\/dx.doi.org\/10.1039\/C4CC03623A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)","URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Received 13 May 2014; Accepted 10 June 2014;  Accepted Manuscript published 10 June 2014;  Advance Article published 1 July 2014;  Version of Record published 15 July 2014","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}