{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:37:49Z","timestamp":1791113869995,"version":"4.1.0"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["51221892"],"award-info":[{"award-number":["51221892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Environ. Sci.: Processes Impacts"],"abstract":"<p>\n                    The occurrence, fate and environmental impact of multiple-class pharmaceuticals were comparatively investigated in two wastewater treatment plants (upgraded\n                    <italic>vs.<\/italic>\n                    conventional) in East China.\n                  <\/p>","DOI":"10.1039\/c4em00596a","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T05:02:05Z","timestamp":1421643725000},"page":"596-605","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Distribution, mass load and environmental impact of multiple-class pharmaceuticals in conventional and upgraded municipal wastewater treatment plants in East China"],"prefix":"10.1039","volume":"17","author":[{"given":"Xiangjuan","family":"Yuan","sequence":"first","affiliation":[{"name":"Research Center for Eco-Environmental Sciences"},{"name":"Chinese Academy of Sciences"},{"name":"Beijing 100085"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Qiang","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences"},{"name":"Chinese Academy of Sciences"},{"name":"Beijing 100085"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Ben","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences"},{"name":"Chinese Academy of Sciences"},{"name":"Beijing 100085"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences"},{"name":"Chinese Academy of Sciences"},{"name":"Beijing 100085"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuhui","family":"Qu","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences"},{"name":"Chinese Academy of Sciences"},{"name":"Beijing 100085"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C4EM00596A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00216-008-1854-x","volume":"391","author":"Kasprzyk-Hordern","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"C4EM00596A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1039\/c000408c","volume":"39","author":"Kasprzyk-Hordern","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"C4EM00596A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1039\/c0em00068j","volume":"12","author":"Oulton","year":"2010","journal-title":"J. Environ. Monit."},{"key":"C4EM00596A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.watres.2007.07.031","volume":"42","author":"Gulkowska","year":"2008","journal-title":"Water Res."},{"key":"C4EM00596A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.watres.2010.11.010","volume":"45","author":"Jelic","year":"2011","journal-title":"Water Res."},{"key":"C4EM00596A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.chemosphere.2011.11.019","volume":"86","author":"Gao","year":"2012","journal-title":"Chemosphere"},{"key":"C4EM00596A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.watres.2011.10.055","volume":"46","author":"Jia","year":"2012","journal-title":"Water Res."},{"key":"C4EM00596A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.scitotenv.2012.04.028","volume":"429","author":"Verlicchi","year":"2012","journal-title":"Sci. Total Environ."},{"key":"C4EM00596A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jhazmat.2013.08.040","volume":"262","author":"Bu","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"C4EM00596A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.2166\/wst.2010.938","volume":"62","author":"Kaindl","year":"2010","journal-title":"Water Sci. Technol."},{"key":"C4EM00596A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2166\/wrd.2011.038","volume":"1","author":"Ahmadi","year":"2011","journal-title":"J. Water Reuse Desalin."},{"key":"C4EM00596A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1016\/j.scitotenv.2011.07.015","volume":"409","author":"Behera","year":"2011","journal-title":"Sci. Total Environ."},{"key":"C4EM00596A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/es050991m","volume":"40","author":"Castiglioni","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"C4EM00596A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1021\/es030653q","volume":"38","author":"Miao","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"C4EM00596A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.watres.2006.12.017","volume":"41","author":"Vieno","year":"2007","journal-title":"Water Res."},{"key":"C4EM00596A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1021\/es034368i","volume":"37","author":"McArdell","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"C4EM00596A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.jes.2014.06.022","volume":"26","author":"Yuan","year":"2014","journal-title":"J. Environ. Sci."},{"key":"C4EM00596A-(cit18)\/*[position()=1]","unstructured":"European Commission. Technical Guidance Document on Risk Assessment in Support of Commission Directive 93\/67\/EEC on risk assessment for new notified substances, Commission Regulation (EC) no. 1488\/94 on risk assessment for existing substances, and Directive 98\/8\/EC of the European Parliament and of the council concerning the placing of biocidal products on the market, Part II. EUR 20418 EN\/2, Ispra, Italy: Joint Research Centre, 2003"},{"key":"C4EM00596A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0378-4274(03)00257-1","volume":"144","author":"Sanderson","year":"2003","journal-title":"Toxicol. Lett."},{"key":"C4EM00596A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.scitotenv.2012.10.001","volume":"442","author":"Yu","year":"2013","journal-title":"Sci. Total Environ."},{"key":"C4EM00596A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/etc.161","volume":"29","author":"Zhao","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"C4EM00596A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2011.03.004","volume":"42","author":"Leung","year":"2012","journal-title":"Environ. Int."},{"key":"C4EM00596A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.chemosphere.2011.03.022","volume":"84","author":"Pan","year":"2011","journal-title":"Chemosphere"},{"key":"C4EM00596A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chemosphere.2006.03.026","volume":"65","author":"Sarmah","year":"2006","journal-title":"Chemosphere"},{"key":"C4EM00596A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1016\/j.envpol.2011.04.037","volume":"159","author":"Zou","year":"2011","journal-title":"Environ. Pollut."},{"key":"C4EM00596A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.scitotenv.2013.09.032","volume":"470\u2013471","author":"Yan","year":"2014","journal-title":"Sci. Total Environ."},{"key":"C4EM00596A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1021\/es0264448","volume":"37","author":"Golet","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"C4EM00596A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.chemosphere.2013.10.062","volume":"99","author":"Yan","year":"2014","journal-title":"Chemosphere"},{"key":"C4EM00596A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1016\/j.watres.2007.06.023","volume":"41","author":"Xu","year":"2007","journal-title":"Water Res."},{"key":"C4EM00596A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.watres.2008.10.047","volume":"43","author":"Kasprzyk-Hordern","year":"2009","journal-title":"Water Res."},{"key":"C4EM00596A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.chemosphere.2013.06.007","volume":"93","author":"Chen","year":"2013","journal-title":"Chemosphere"},{"key":"C4EM00596A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1021\/es903490h","volume":"44","author":"Li","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"C4EM00596A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1021\/es050261e","volume":"39","author":"Miao","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"C4EM00596A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.trac.2008.10.001","volume":"27","author":"Garc\u00eda-Gal\u00e1n","year":"2008","journal-title":"TrAC, Trends Anal. Chem."},{"key":"C4EM00596A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1897\/04-144R.1","volume":"24","author":"Thomas","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"C4EM00596A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.scitotenv.2006.07.039","volume":"372","author":"G\u00f6bel","year":"2007","journal-title":"Sci. Total Environ."},{"key":"C4EM00596A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1021\/es100778d","volume":"44","author":"Ort","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"C4EM00596A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1021\/es035368l","volume":"38","author":"Pinkston","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"C4EM00596A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.1021\/es060835v","volume":"40","author":"Batt","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"C4EM00596A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jenvman.2013.02.007","volume":"120","author":"Dorival-Garc\u00eda","year":"2013","journal-title":"J. Environ. Manage."},{"key":"C4EM00596A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1080\/10643380903392692","volume":"41","author":"Zhang","year":"2011","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"C4EM00596A-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.scitotenv.2013.03.010","volume":"452\u2013453","author":"Zhou","year":"2013","journal-title":"Sci. Total Environ."},{"key":"C4EM00596A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.chemosphere.2011.12.025","volume":"87","author":"Gracia-Lor","year":"2012","journal-title":"Chemosphere"},{"key":"C4EM00596A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.scitotenv.2005.06.030","volume":"361","author":"Karthikeyan","year":"2006","journal-title":"Sci. Total Environ."},{"key":"C4EM00596A-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1021\/es048143z","volume":"39","author":"Lindberg","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"C4EM00596A-(cit46)\/*[position()=1]","unstructured":"EPA 832-R-06-005, Emerging Technologies for Biosolids Management, Washington, DC, Office of Wastewater Management, US Environmental Protection Agency, 2006"},{"key":"C4EM00596A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.scitotenv.2012.01.061","volume":"421","author":"Gao","year":"2012","journal-title":"Sci. Total Environ."},{"key":"C4EM00596A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.scitotenv.2013.03.071","volume":"456\u2013457","author":"Huerta","year":"2013","journal-title":"Sci. Total Environ."},{"key":"C4EM00596A-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.chemosphere.2008.12.006","volume":"75","author":"K\u00fcmmerer","year":"2009","journal-title":"Chemosphere"},{"key":"C4EM00596A-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0045-6535(99)00443-9","volume":"40","author":"Wollenberger","year":"2000","journal-title":"Chemosphere"},{"key":"C4EM00596A-(cit51)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2014.08.053","author":"Petrie","year":"2014","journal-title":"Water Res."},{"key":"C4EM00596A-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jhazmat.2009.10.100","volume":"175","author":"Santos","year":"2010","journal-title":"J. Hazard. Mater."},{"key":"C4EM00596A-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.toxlet.2007.10.012","volume":"176","author":"Besse","year":"2008","journal-title":"Toxicol. Lett."},{"key":"C4EM00596A-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.scitotenv.2004.11.017","volume":"346","author":"Isidori","year":"2005","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Science: Processes &amp; Impacts"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/EM\/C4EM00596A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:52:35Z","timestamp":1782877955000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/em\/article\/17\/3\/596-605\/438199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c4em00596a","relation":{},"ISSN":["2050-7887","2050-7895"],"issn-type":[{"value":"2050-7887","type":"print"},{"value":"2050-7895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C4EM00596A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 8 November 2014; Accepted 10 January 2015; Accepted Manuscript published 19 January 2015; Advance Article published 23 January 2015; Version of Record published 11 March 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}