{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:32:43Z","timestamp":1783017163321,"version":"3.54.6"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Faraday Discuss."],"abstract":"<p>\n                    We report investigations on the formation of mesostructured solutions in\n                    <sc>dl<\/sc>\n                    -valine\u2013water\u20132-propanol mixtures, and the crystallization of\n                    <sc>dl<\/sc>\n                    -valine from these solutions. Mesostructured liquid phases, similar to those previously observed in aqueous solutions of glycine and\n                    <sc>dl<\/sc>\n                    -alanine, were observed using Dynamic Light Scattering and Brownian microscopy, in both undersaturated and supersaturated solutions below a certain transition temperature. Careful experimentation was used to demonstrate that the optically clear mesostructured liquid phase, comprising colloidal mesoscale clusters dispersed within bulk solution, is thermodynamically stable and present in equilibrium with the solid phase at saturation conditions. Solutions prepared by slow cooling contained mesoscale clusters with a narrow size distribution and a mean hydrodynamic diameter of around 200 nm. Solutions of identical composition prepared by rapid isothermal mixing of valine aqueous solutions with 2-propanol contained mesoscale clusters which were significantly larger than those observed in slowly cooled solutions. The presence of larger mesoscale clusters was found to correspond to faster nucleation. Observed induction times were strongly dependent on the rapid initial mixing step, although solutions were left undisturbed afterwards and the induction times observed were up to two orders of magnitude longer than the initial mixing period. We propose that mesoscale clusters above a certain critical size are likely to be the location of productive nucleation events.\n                  <\/p>","DOI":"10.1039\/c4fd00262h","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T09:01:48Z","timestamp":1422522108000},"page":"141-154","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of mixing, concentration and temperature on the formation of mesostructured solutions and their role in the nucleation of\n                    <scp>dl<\/scp>\n                    -valine crystals"],"prefix":"10.1039","volume":"179","author":[{"given":"Anna","family":"Jawor-Baczynska","sequence":"first","affiliation":[{"name":"EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallization"},{"name":"Department of Chemical and Process Engineering"},{"name":"University of Strathclyde"},{"name":"Glasgow G1 1XJ"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry D.","family":"Moore","sequence":"additional","affiliation":[{"name":"WestCHEM"},{"name":"Department of Pure and Applied Chemistry"},{"name":"University of Strathclyde"},{"name":"Glasgow G1 1XL"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sefcik","sequence":"additional","affiliation":[{"name":"EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallization"},{"name":"Department of Chemical and Process Engineering"},{"name":"University of Strathclyde"},{"name":"Glasgow G1 1XJ"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C4FD00262H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/cg025514j","volume":"2","author":"Davey","year":"2002","journal-title":"Cryst. 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