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Current chemomics and pharmacology proved that the total alkaloids (TA), total gingerols (TG), total flavones and total saponins (TFS) are the major active ingredients of Aconitum carmichaelii, Zingiber officinale and Glycyrrhiza uralensis in SND respectively. Our animal experiments in this study demonstrated that the above active ingredients (TAGFS) were more effective than formulas formed by any one or two of the three individual components and nearly the same as SND. However, very little is known about the action mechanisms of TAGFS. Thus, this study aimed to use for the first time the combination of GC\/LC-MS based metabolomics and network pharmacology for solving this problem. By metabolomics, it was found that TAGFS worked by regulating six primary pathways. Then, network pharmacology was applied to search for specific targets. 17 potential cardiovascular related targets were found through molecular docking, 11 of which were identified by references, which demonstrated the therapeutic effectiveness of TAGFS using network pharmacology. Among these targets, four targets, including phosphoinositide 3-kinase gamma, insulin receptor, ornithine aminotransferase and glucokinase, were involved in the TAGFS regulated pathways. Moreover, phosphoinositide 3-kinase gamma, insulin receptor and glucokinase were proved to be targets of active components in SND. In addition, our data indicated TA as the principal ingredient in the SND formula, whereas TG and TFS served as adjuvant ingredients. We therefore suggest that dissecting the mode of action of clinically effective formulae with the combination use of metabolomics and network pharmacology may be a good strategy.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c4mb00048j","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T09:01:52Z","timestamp":1411549312000},"page":"3310-3321","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Investigation of the therapeutic effectiveness of active components in\n                    <i>Sini<\/i>\n                    decoction by a comprehensive GC\/LC-MS based metabolomics and network pharmacology approaches"],"prefix":"10.1093","volume":"10","author":[{"given":"Si","family":"Chen","sequence":"first","affiliation":[{"name":"School of Pharmacy, Second Military Medical University a , 325 Guohe Road, Shanghai, 200433 China \u00a0 yfchai@smmu.edu.cn \u00a0 zzyzyfzhu@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Wu","sequence":"additional","affiliation":[{"name":"Gene and Small Molecules Group, Max Planck Institute of Molecular Plant Physiology b , 14476 Potsdam-Golm, Germany"},{"name":"School of Pharmacy, Second Military Medical University a , 325 Guohe Road, Shanghai, 200433 China \u00a0 yfchai@smmu.edu.cn \u00a0 zzyzyfzhu@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuhong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Second Military Medical University a , 325 Guohe Road, Shanghai, 200433 China \u00a0 yfchai@smmu.edu.cn \u00a0 zzyzyfzhu@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Second Military Medical University a , 325 Guohe Road, Shanghai, 200433 China \u00a0 yfchai@smmu.edu.cn \u00a0 zzyzyfzhu@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Second Military Medical University a , 325 Guohe Road, Shanghai, 200433 China \u00a0 yfchai@smmu.edu.cn \u00a0 zzyzyfzhu@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangguo","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, Fourth Military Medical University c , Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University d , 225 Changhai Road, Shanghai, 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanying","family":"Hong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Second Military Medical University a , 325 Guohe Road, Shanghai, 200433 China \u00a0 yfchai@smmu.edu.cn \u00a0 zzyzyfzhu@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Second Military Medical University a , 325 Guohe Road, Shanghai, 200433 China \u00a0 yfchai@smmu.edu.cn \u00a0 zzyzyfzhu@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Chai","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Second Military Medical University a , 325 Guohe Road, Shanghai, 200433 China \u00a0 yfchai@smmu.edu.cn \u00a0 zzyzyfzhu@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,9,24]]},"reference":[{"key":"2026010815092985400_cit1","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.287.5460.1960","volume":"287","author":"Drews","year":"2000","journal-title":"Science"},{"key":"2026010815092985400_cit2","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1073\/pnas.0712365105","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. 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