{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:44:28Z","timestamp":1770414268775,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T00:00:00Z","timestamp":1395964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cervical cancer is a clinical and pathological heterogeneity disease, which requires different types of treatments and leads to a variety of outcomes. In clinical practice, only some patients benefit from chemotherapy treatment. Identifying patients who will be responsive to chemotherapy could increase their survival time, which has important implications in personalized treatment and outcomes, while identifying non-responders may reduce the likelihood for these patients to receive ineffective treatment and thereby enable them to receive other potentially effective treatments. Plasma metabolite profiling was performed in this study to identify the potential biomarkers that could predict the response to neoadjuvant chemotherapy (NACT) for cervical cancer patients. The metabolic profiles of plasma from 38 cervical cancer patients with a complete, partial and non-response to NACT were studied using a combination of liquid chromatography coupled with mass spectrometry (LC\/MS) and multivariate analysis methods. l-Valine and l-tryptophan were finally identified and verified as the potential biomarkers. A prediction model constructed with l-valine and l-tryptophan correctly identified approximately 80% of patients who were non-response to chemotherapy and 87% of patients who were had a pathologically complete response to chemotherapy. The model has an excellent discriminant performance with an AUC of 0.9407. These results show promise for larger studies that could produce more personalized treatment protocols for cervical cancer patients.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c4mb00054d","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T19:08:54Z","timestamp":1396033734000},"page":"2126-2133","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["A metabolomics approach for predicting the response to neoadjuvant chemotherapy in cervical cancer patients"],"prefix":"10.1093","volume":"10","author":[{"given":"Yan","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Harbin Medical University a , Harbin 150081, China likang@ems.hrbmu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhu","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Gynecology Oncology, The Tumor Hospital of Harbin Medical University b , Harbin 150086, China louge@ems.hrbmu.edu.cn +86-451-86298303 +86-451-86298303"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Harbin Medical University c , Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Public Health School, Shandong University d , Jinan, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington e , Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Oncology, The Tumor Hospital of Harbin Medical University f , Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Oncology, The Tumor Hospital of Harbin Medical University f , Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology Oncology, The Tumor Hospital of Harbin Medical University b , Harbin 150086, China louge@ems.hrbmu.edu.cn +86-451-86298303 +86-451-86298303"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Tumor Hospital of Harbin Medical University g , Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Tumor Hospital of Harbin Medical University g , Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Gynecology Oncology, The Tumor Hospital of Harbin Medical University b , Harbin 150086, China louge@ems.hrbmu.edu.cn +86-451-86298303 +86-451-86298303"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Harbin Medical University a , Harbin 150081, China likang@ems.hrbmu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,3,28]]},"reference":[{"key":"2026010815133525600_cit1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1023\/A:1012761717028","volume":"17","author":"Hemminki","year":"2001","journal-title":"Eur. J. Epidemiol."},{"key":"2026010815133525600_cit2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/(SICI)1097-0215(20000501)86:3<429::AID-IJC20>3.0.CO;2-D","volume":"86","author":"Vizcaino","year":"2000","journal-title":"Int. J. Cancer"},{"key":"2026010815133525600_cit3","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1056\/NEJMp068031","volume":"354","author":"Katz","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"2026010815133525600_cit4","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1056\/NEJM199904153401502","volume":"340","author":"Rose","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"2026010815133525600_cit5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/1097-0142(19910115)67:2<372::AID-CNCR2820670210>3.0.CO;2-5","article-title":"et al.","volume":"67","author":"Panici","year":"1991","journal-title":"Cancer"},{"key":"2026010815133525600_cit6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0305-7372(03)00068-9","volume":"29","author":"Duenas-Gonzalez","year":"2003","journal-title":"Cancer Treat. Rev."},{"key":"2026010815133525600_cit7","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/gyno.1998.5079","volume":"70","author":"Iwasaka","year":"1998","journal-title":"Gynecol. Oncol."},{"key":"2026010815133525600_cit8","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1038\/sj.bjc.6601870","volume":"90","author":"deSouza","year":"2004","journal-title":"Br. J. Cancer"},{"key":"2026010815133525600_cit9","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1002\/(SICI)1097-0142(19961201)78:11<2359::AID-CNCR14>3.0.CO;2-#","volume":"78","author":"Benedetti-Panici","year":"1996","journal-title":"Cancer"},{"key":"2026010815133525600_cit10","first-page":"92","volume":"21","author":"Yin","year":"2011","journal-title":"Int. J. Gynecol. Cancer"},{"key":"2026010815133525600_cit11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00000421-199712000-00017","volume":"20","author":"Micheletti","year":"1997","journal-title":"Am. J. Clin. Oncol."},{"key":"2026010815133525600_cit12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ygyno.2003.09.015","volume":"92","author":"Park","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"2026010815133525600_cit13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"2026010815133525600_cit14","first-page":"8","volume":"18","author":"Peters 3rd","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"2026010815133525600_cit15","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1002\/cncr.23817","volume":"113","author":"Vincens","year":"2008","journal-title":"Cancer"},{"key":"2026010815133525600_cit16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/IGC.0b013e31825736d7","volume":"22","author":"Fu","year":"2012","journal-title":"Int. J. Gynecol. Cancer"},{"key":"2026010815133525600_cit17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3109\/00016349509024411","volume":"74","author":"Vives","year":"1995","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"2026010815133525600_cit18","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ygyno.2006.06.016","volume":"103","author":"Chung","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"2026010815133525600_cit19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ygyno.2008.08.034","volume":"111","author":"Kim","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"2026010815133525600_cit20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0959-8049(95)00515-3","volume":"32","author":"Scambia","year":"1996","journal-title":"Eur. J. Cancer"},{"key":"2026010815133525600_cit21","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1586\/14737159.8.5.617","volume":"8","author":"Gowda","year":"2008","journal-title":"Expert Rev. Mol. Diagn."},{"key":"2026010815133525600_cit22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/pr3009572","volume":"12","author":"Zhang","year":"2013","journal-title":"J. Proteome Res."},{"key":"2026010815133525600_cit23","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cca.2012.01.026","volume":"413","author":"Zhang","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"2026010815133525600_cit24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.molonc.2012.05.003","volume":"6","author":"Tenori","year":"2012","journal-title":"Mol. Oncol."},{"key":"2026010815133525600_cit25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.molonc.2012.10.003","volume":"7","author":"Wei","year":"2013","journal-title":"Mol. Oncol."},{"key":"2026010815133525600_cit26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1207\/s15328031us0304_4","volume":"3","author":"Michael Haenlein","year":"2004","journal-title":"Understanding Statistics"},{"key":"2026010815133525600_cit27","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/cem.785","volume":"17","author":"atthew Barker","year":"2003","journal-title":"J. Chemom."},{"key":"2026010815133525600_cit28","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/01621459.1994.10476452","volume":"89","author":"Garthwaitea","year":"1994","journal-title":"J. Am. Stat. Assoc."},{"key":"2026010815133525600_cit29","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cca.2012.01.026","volume":"413","author":"Zhang","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"2026010815133525600_cit30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.chroma.2007.04.021","volume":"1158","author":"Katajamaa","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"2026010815133525600_cit31","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2164-7-142","volume":"7","author":"van den Berg","year":"2006","journal-title":"BMC Genomics"},{"key":"2026010815133525600_cit32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/bib\/bbl016","volume":"8","author":"Boulesteix","year":"2007","journal-title":"Briefings Bioinf."},{"key":"2026010815133525600_cit33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","volume":"45","author":"Breiman","year":"2001","journal-title":"Mach. Learn."},{"key":"2026010815133525600_cit34","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s11306-011-0302-7","volume":"8","author":"Xie","year":"2011","journal-title":"Metabolomics"},{"key":"2026010815133525600_cit35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nri2233","volume":"8","author":"Mellor","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2026010815133525600_cit36","doi-asserted-by":"crossref","first-page":"17073","DOI":"10.1073\/pnas.0806173105","volume":"105","author":"Muller","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026010815133525600_cit37","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.2174\/092986711795656072","volume":"18","author":"Prendergast","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"2026010815133525600_cit38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0014-2964(76)90036-0","volume":"12","author":"Lundholm","year":"1976","journal-title":"Eur. J. Cancer (1965-1981)"}],"container-title":["Molecular BioSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article-pdf\/10\/8\/2126\/65462855\/c4mb00054d.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article-pdf\/10\/8\/2126\/65462855\/c4mb00054d.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:22:16Z","timestamp":1767903736000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article\/10\/8\/2126\/8324221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,28]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,3,28]]}},"URL":"https:\/\/doi.org\/10.1039\/c4mb00054d","relation":{},"ISSN":["1742-2051","1742-206X"],"issn-type":[{"value":"1742-2051","type":"electronic"},{"value":"1742-206X","type":"print"}],"subject":[],"published-other":{"date-parts":[[2014,8,1]]},"published":{"date-parts":[[2014,3,28]]},"assertion":[{"value":"This document is CrossCheck deposited","name":"crosscheck","explanation":{"URL":"http:\/\/www.crossref.org\/crosscheck\/index.html"},"group":{"name":"crosscheck","label":"CROSSCHECK"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Received 26 January 2014; Accepted 28 March 2014; Accepted Manuscript published 28 March 2014; Advance Article published 28 May 2014; Version of Record published 1 July 2014","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}