{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:27:43Z","timestamp":1788280063059,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The main physiological challenge in high-altitude plateau environments is hypoxia. When people living in a plain environment migrate to the plateau, they face the threat of hypoxia. Most people can acclimatize to high altitudes; the acclimatization process mainly consists of short-term hyperventilation and long-term compensation by increased oxygen uptake, transport, and use due to increased red blood cell mass, myoglobin, and mitochondria. If individuals cannot acclimatize to high altitude, they may suffer from a high-altitude disease, such as acute mountain disease (AMS), high-altitude pulmonary edema (HAPE), high-altitude cerebral edema (HACE) or chronic mountain sickness (CMS). Because some individuals are more susceptible to high altitude diseases than others, the incidence of these high-altitude diseases is variable and cannot be predicted. Studying \u201comes\u201d using genomics, proteomics, metabolomics, transcriptomics, lipidomics, immunomics, glycomics and RNomics can help us understand the factors that mediate susceptibility to high altitude illnesses. Moreover, analysis of the \u201comes\u201d using a systems biology approach may provide a greater understanding of high-altitude illness pathogenesis and improve the efficiency of the diagnosis and treatment of high-altitude illnesses in the future. Below, we summarize the current literature regarding the role of \u201comes\u201d in high-altitude acclimatization\/adaptation and disease and discuss key research gaps to better understand the contribution of \u201comes\u201d to high-altitude illness susceptibility.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c4mb00119b","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T11:51:38Z","timestamp":1406634698000},"page":"2748-2755","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["\u2018Ome\u2019 on the range: update on high-altitude acclimatization\/adaptation and disease"],"prefix":"10.1093","volume":"10","author":[{"given":"Yongjun","family":"Luo","sequence":"first","affiliation":[{"name":"Key Laboratory of High Altitude medicine (People's Liberation Army), Third Military Medical University c , Chongqing 400038, China"},{"name":"Key Laboratory of High Altitude Medicine (Ministry of Education), Third Military Medical University b , Chongqing 400038, China"},{"name":"Department of Military Medical Geography, Third Military Medical University a , Chongqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Battalion 5 of Cadet Brigade, Third Military Medical University d , Chongqing 400038, PR China"},{"name":"Key Laboratory of High Altitude medicine (People's Liberation Army), Third Military Medical University c , Chongqing 400038, China"},{"name":"Key Laboratory of High Altitude Medicine (Ministry of Education), Third Military Medical University b , Chongqing 400038, China"},{"name":"Department of Military Medical Geography, Third Military Medical University a , Chongqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Battalion 5 of Cadet Brigade, Third Military Medical University d , Chongqing 400038, PR China"},{"name":"Key Laboratory of High Altitude medicine (People's Liberation Army), Third Military Medical University c , Chongqing 400038, China"},{"name":"Key Laboratory of High Altitude Medicine (Ministry of Education), Third Military Medical University b , Chongqing 400038, China"},{"name":"Department of Military Medical Geography, Third Military Medical University a , Chongqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Gao","sequence":"additional","affiliation":[{"name":"College of High Altitude Military Medicine, Third Military Medical University e , Chongqing 400038, PR China \u00a0 gaoy66@yahoo.com \u00a0 +86 23 6875 2384 \u00a0 +86 23 6875 2381"},{"name":"Key Laboratory of High Altitude medicine (People's Liberation Army), Third Military Medical University c , Chongqing 400038, China"},{"name":"Key Laboratory of High Altitude Medicine (Ministry of Education), Third Military Medical University b , Chongqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,7,29]]},"reference":[{"key":"2026010815092452700_cit1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijcard.2013.08.059","volume":"169","author":"Luo","year":"2013","journal-title":"Int. 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