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Metabolomics has the potential to reveal the effect of METH abuse on systemic metabolism and potential markers suggesting the underlying mechanism of toxicity. In this study, male Sprague Dawley rats were intraperitoneally injected with METH at escalating doses of mg kg\u22121 for 5 consecutive days and then were withdrawn for 2 days. The metabolites in the serum and urine were profiled and the systemic effects of METH on metabolic pathways were evaluated. Multivariate statistical analysis showed that METH caused distinct deviations, whereas the withdrawal of METH restored the metabolic patterns towards baseline. METH administration elevated energy metabolism, which was manifested by the distinct depletion of branched-chain amino acids, accelerated tricarboxylic-acid cycle and lipid metabolism, reduced serum glycerol-3-phosphate, and elevated serum and urinary 3-hydroxybutyrate and urinary glycerol. In addition to the increased serum levels of the excitatory amino acids glutamate and aspartate (the inhibitory neurotransmitters in the brain), a marked decline in serum alanine and glycine after METH treatment suggested the activation and decreased inhibition of the nervous system and hence elevated nervous activity. Withdrawal of METH for 2 days efficiently restored all but a few metabolites to baseline, including serum creatinine, citrate, 2-ketoglutarate, and urinary lactate. Therefore, these metabolites are potential markers of METH use, and they may be used to facilitate the diagnosis of METH abuse.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c4mb00158c","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T09:01:57Z","timestamp":1398762117000},"page":"1968-1977","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The metabolic impact of methamphetamine on the systemic metabolism of rats and potential markers of methamphetamine abuse"],"prefix":"10.1093","volume":"10","author":[{"given":"Tian","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Police Technology, Jiangsu Police Institute b , 48, Sangong, Nangjing 210031, Jiangsu province, China"},{"name":"Lab of Metabonomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University a , No. 24, Tongjia Road, Nanjing 210009, Jiangsu province, China jiyea@cpu.edu.cn +86 25 83271060 +86 25 83271192"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Lab of Metabonomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University a , No. 24, Tongjia Road, Nanjing 210009, Jiangsu province, China jiyea@cpu.edu.cn +86 25 83271060 +86 25 83271192"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Shi","sequence":"additional","affiliation":[{"name":"Lab of Metabonomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University a , No. 24, Tongjia Road, Nanjing 210009, Jiangsu province, China jiyea@cpu.edu.cn +86 25 83271060 +86 25 83271192"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Yu","sequence":"additional","affiliation":[{"name":"Lab of Metabonomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University a , No. 24, Tongjia Road, Nanjing 210009, Jiangsu province, China jiyea@cpu.edu.cn +86 25 83271060 +86 25 83271192"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Lab of Metabonomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University a , No. 24, Tongjia Road, Nanjing 210009, Jiangsu province, China jiyea@cpu.edu.cn +86 25 83271060 +86 25 83271192"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runbing","family":"Sun","sequence":"additional","affiliation":[{"name":"Lab of Metabonomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University a , No. 24, Tongjia Road, Nanjing 210009, Jiangsu province, China jiyea@cpu.edu.cn +86 25 83271060 +86 25 83271192"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Police Technology, Jiangsu Police Institute b , 48, Sangong, Nangjing 210031, Jiangsu province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiye","family":"Aa","sequence":"additional","affiliation":[{"name":"Lab of Metabonomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University a , No. 24, Tongjia Road, Nanjing 210009, Jiangsu province, China jiyea@cpu.edu.cn +86 25 83271060 +86 25 83271192"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangji","family":"Wang","sequence":"additional","affiliation":[{"name":"Lab of Metabonomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University a , No. 24, Tongjia Road, Nanjing 210009, Jiangsu province, China jiyea@cpu.edu.cn +86 25 83271060 +86 25 83271192"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,4,29]]},"reference":[{"key":"2026010815094860200_cit1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/105984050602200202","volume":"22","author":"Gettig","year":"2006","journal-title":"J. Sch. Nurs."},{"key":"2026010815094860200_cit2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1037\/1064-1297.13.4.357","volume":"13","author":"Shoal","year":"2005","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"2026010815094860200_cit3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/10673220591003605","volume":"13","author":"Meredith","year":"2005","journal-title":"Harv. Rev. Psychiatry"},{"key":"2026010815094860200_cit4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0173(01)00054-6","volume":"36","author":"Davidson","year":"2001","journal-title":"Brain Res. Rev."},{"key":"2026010815094860200_cit5","author":"Jayanthi","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"2026010815094860200_cit6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(98)00656-8","volume":"806","author":"Fukumura","year":"1998","journal-title":"Brain Res."},{"key":"2026010815094860200_cit7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0006-8993(00)03244-3","volume":"892","author":"Sabol","year":"2001","journal-title":"Brain Res."},{"key":"2026010815094860200_cit8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/joim.12049","volume":"273","author":"Ares-Santos","year":"2013","journal-title":"J. Intern. Med."},{"key":"2026010815094860200_cit9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0006-8993(80)90952-X","volume":"193","author":"Ricaurte","year":"1980","journal-title":"Brain Res."},{"key":"2026010815094860200_cit10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0006-8993(80)91265-2","volume":"181","author":"Wagner","year":"1980","journal-title":"Brain Res."},{"key":"2026010815094860200_cit11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/npp.2011.248","volume":"37","author":"Lominac","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"2026010815094860200_cit12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1254\/fpj.74.27","volume":"74","author":"Honma","year":"1978","journal-title":"Nihon Yakurigaku Zasshi"},{"key":"2026010815094860200_cit13","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1369-1600.2010.00270.x","volume":"17","author":"Henry","year":"2012","journal-title":"Addict. Biol."},{"key":"2026010815094860200_cit14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/00041552-199603000-00004","volume":"5","author":"Bakir","year":"1996","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"2026010815094860200_cit15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1196\/annals.1403.004","volume":"1122","author":"Virmani","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2026010815094860200_cit16","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1523\/JNEUROSCI.23-09-03924.2003","volume":"23","author":"Brown","year":"2003","journal-title":"J. Neurosci."},{"key":"2026010815094860200_cit17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tox.2011.05.012","volume":"287","author":"Shima","year":"2011","journal-title":"Toxicology"},{"key":"2026010815094860200_cit18","doi-asserted-by":"crossref","first-page":"258","DOI":"10.2174\/187152409789630389","volume":"9","author":"Ayala","year":"2009","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"2026010815094860200_cit19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1300\/J069v21n01_03","volume":"21","author":"Cho","year":"2002","journal-title":"J. Addict. Dis."},{"key":"2026010815094860200_cit20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.clpt.2006.06.013","volume":"80","author":"Mendelson","year":"2006","journal-title":"Clin. Pharmacol. Ther."},{"key":"2026010815094860200_cit21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11306-009-0191-1","volume":"6","author":"Smilde","year":"2010","journal-title":"Metabolomics"},{"key":"2026010815094860200_cit22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1146\/annurev.pharmtox.48.113006.094715","volume":"48","author":"Kaddurah-Daouk","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2026010815094860200_cit23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s11306-011-0316-1","volume":"8","author":"Jansen","year":"2012","journal-title":"Metabolomics"},{"key":"2026010815094860200_cit24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11306-010-0262-3","volume":"7","author":"Bai","year":"2011","journal-title":"Metabolomics"},{"key":"2026010815094860200_cit25","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1007\/s11306-013-0517-x","volume":"9","author":"Cao","year":"2013","journal-title":"Metabolomics"},{"key":"2026010815094860200_cit26","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1039\/c2mb25049g","volume":"8","author":"Ouattara","year":"2012","journal-title":"Mol. Biosyst."},{"key":"2026010815094860200_cit27","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1039\/c1mb05057e","volume":"7","author":"Lin","year":"2011","journal-title":"Mol. Biosyst."},{"key":"2026010815094860200_cit28","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2217\/14622416.8.7.731","volume":"8","author":"Keun","year":"2007","journal-title":"Pharmacogenomics"},{"key":"2026010815094860200_cit29","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/004982599238047","volume":"29","author":"Nicholson","year":"1999","journal-title":"Xenobiotica"},{"key":"2026010815094860200_cit30","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1039\/c2mb25044f","volume":"8","author":"Luo","year":"2012","journal-title":"Mol. Biosyst."},{"key":"2026010815094860200_cit31","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1007\/s00216-011-5245-3","volume":"401","author":"Chen","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"2026010815094860200_cit32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.aca.2009.03.039","volume":"650","author":"Chen","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"2026010815094860200_cit33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11306-010-0249-0","volume":"7","author":"Fan","year":"2011","journal-title":"Metabolomics"},{"key":"2026010815094860200_cit34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11306-012-0446-0","volume":"9","author":"Bro","year":"2013","journal-title":"Metabolomics"},{"key":"2026010815094860200_cit35","doi-asserted-by":"crossref","first-page":"e10538","DOI":"10.1371\/journal.pone.0010538","volume":"5","author":"Lanza","year":"2010","journal-title":"PLoS One"},{"key":"2026010815094860200_cit36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11306-011-0291-6","volume":"8","author":"van der Kloet","year":"2012","journal-title":"Metabolomics"},{"key":"2026010815094860200_cit37","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1039\/c3mb25543c","volume":"9","author":"Huang","year":"2013","journal-title":"Mol. Biosyst."},{"key":"2026010815094860200_cit38","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1039\/b914751a","volume":"6","author":"Zhang","year":"2010","journal-title":"Mol. Biosyst."},{"key":"2026010815094860200_cit39","first-page":"790132","volume":"2011","author":"Barderas","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"2026010815094860200_cit40","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S0022-3565(24)35387-X","volume":"292","author":"Riviere","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026010815094860200_cit41","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s11306-012-0456-y","volume":"9","author":"McClay","year":"2013","journal-title":"Metabolomics"},{"key":"2026010815094860200_cit42","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1038\/sj.npp.1300859","volume":"30","author":"Caligiuri","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"2026010815094860200_cit43","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF00496860","volume":"48","author":"Peachey","year":"1976","journal-title":"Psychopharmacology"},{"key":"2026010815094860200_cit44","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1037\/0033-295X.94.4.469","volume":"94","author":"Wise","year":"1987","journal-title":"Psychol. Rev."},{"key":"2026010815094860200_cit45","first-page":"395","volume":"10","author":"Gerald","year":"1975","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"2026010815094860200_cit46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0091-3057(78)90066-7","volume":"8","author":"Stolerman","year":"1978","journal-title":"Pharmacol., Biochem. Behav."},{"key":"2026010815094860200_cit47","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0091-3057(81)90306-3","volume":"14","author":"Bittner","year":"1981","journal-title":"Pharmacol., Biochem. Behav."},{"key":"2026010815094860200_cit48","first-page":"619","volume":"44","author":"Hada","year":"1990","journal-title":"Jpn. J. Psychiatry Neurol."},{"key":"2026010815094860200_cit49","first-page":"401","volume":"57","author":"Montanaro","year":"1981","journal-title":"Boll. - Soc. Ital. Biol. Sper."},{"key":"2026010815094860200_cit50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1990.tb19297.x","volume":"193","author":"Downes","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"2026010815094860200_cit51","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1081\/LPR-200029889","volume":"14","author":"Komatsu","year":"2004","journal-title":"J. Liposome Res."},{"key":"2026010815094860200_cit52","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.drugalcdep.2012.06.031","volume":"127","author":"Zheng","year":"2013","journal-title":"Drug Alcohol Depend."},{"key":"2026010815094860200_cit53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ab.2008.04.026","volume":"379","author":"Huang","year":"2008","journal-title":"Anal. Biochem."},{"key":"2026010815094860200_cit54","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ab.2010.07.015","volume":"406","author":"Liu","year":"2010","journal-title":"Anal. Biochem."},{"key":"2026010815094860200_cit55","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neuroscience.2013.10.023","volume":"256","author":"Zheng","year":"2014","journal-title":"Neuroscience"},{"key":"2026010815094860200_cit56","doi-asserted-by":"crossref","first-page":"8086","DOI":"10.1021\/ac051211v","volume":"77","author":"Trygg","year":"2005","journal-title":"Anal. Chem."},{"key":"2026010815094860200_cit57","doi-asserted-by":"crossref","first-page":"W127","DOI":"10.1093\/nar\/gks374","volume":"40","author":"Xia","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2026010815094860200_cit58","doi-asserted-by":"crossref","first-page":"W652","DOI":"10.1093\/nar\/gkp356","volume":"37","author":"Xia","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2026010815094860200_cit59","first-page":"91","volume":"59","author":"Szpetnar","year":"2004","journal-title":"Ann. Univ. Mariae Curie-Sklodowska, Sect. D"},{"key":"2026010815094860200_cit60","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF01427055","volume":"66","author":"Snyder","year":"1993","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"2026010815094860200_cit61","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0278-5919(05)70162-9","volume":"18","author":"Ivy","year":"1999","journal-title":"Clinics in Sports Medicine"},{"key":"2026010815094860200_cit62","first-page":"107","volume":"37","author":"Kaiya","year":"1983","journal-title":"Folia Psychiatr. Neurol. Jpn."},{"key":"2026010815094860200_cit63","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.neuroimage.2009.06.062","volume":"48","author":"Chang","year":"2009","journal-title":"NeuroImage"},{"key":"2026010815094860200_cit64","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11481-008-9108-4","volume":"3","author":"Ernst","year":"2008","journal-title":"J. Neuroimmune. Pharmacol."},{"key":"2026010815094860200_cit65","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2131\/jts.8.25","volume":"8","author":"Kuribara","year":"1983","journal-title":"J. Toxicol. Sci."},{"key":"2026010815094860200_cit66","first-page":"97","volume":"27","author":"Sangiah","year":"1985","journal-title":"Vet. Hum. Toxicol."},{"key":"2026010815094860200_cit67","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/mrm.1910040303","volume":"4","author":"Renshaw","year":"1987","journal-title":"Magn. Reson. Med."},{"key":"2026010815094860200_cit68","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.drugalcdep.2006.09.011","volume":"88","author":"Sung","year":"2007","journal-title":"Drug Alcohol Depend."},{"key":"2026010815094860200_cit69","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1212\/WNL.54.6.1344","volume":"54","author":"Ernst","year":"2000","journal-title":"Neurology"},{"key":"2026010815094860200_cit70","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11596-012-0072-0","volume":"32","author":"Yue","year":"2012","journal-title":"J. Huazhong Univ. Sci. Technol., Med. Sci."},{"key":"2026010815094860200_cit71","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3109\/15376516.2012.730561","volume":"23","author":"Koriem","year":"2013","journal-title":"Toxicol. Mech. 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