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In this work, we designed and synthesized a cyclen-hybrid artificial \u2018hydrolase\u2019 I1-Cu(ii) to cleave tau in vitro. Furthermore, a cell-permeable \u2018hydrolase\u2019 I2-Cu(ii), derived from I1-Cu(ii), was also synthesized to cleave intracellular tau proteins.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c4mb00508b","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T11:03:05Z","timestamp":1411729385000},"page":"3081-3085","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase"],"prefix":"10.1093","volume":"10","author":[{"given":"Ting-Ting","family":"Chu","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University a , Beijing 100084, China \u00a0 chen-yx@mail.tsinghua.edu.cn \u00a0 liym@mail.tsinghua.edu.cn \u00a0 +86-10-6278-1695 \u00a0 +86-10-6279-6197"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian-Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University a , Beijing 100084, China \u00a0 chen-yx@mail.tsinghua.edu.cn \u00a0 liym@mail.tsinghua.edu.cn \u00a0 +86-10-6278-1695 \u00a0 +86-10-6279-6197"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Qiu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University a , Beijing 100084, China \u00a0 chen-yx@mail.tsinghua.edu.cn \u00a0 liym@mail.tsinghua.edu.cn \u00a0 +86-10-6278-1695 \u00a0 +86-10-6279-6197"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan-Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University a , Beijing 100084, China \u00a0 chen-yx@mail.tsinghua.edu.cn \u00a0 liym@mail.tsinghua.edu.cn \u00a0 +86-10-6278-1695 \u00a0 +86-10-6279-6197"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Wen","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University a , Beijing 100084, China \u00a0 chen-yx@mail.tsinghua.edu.cn \u00a0 liym@mail.tsinghua.edu.cn \u00a0 +86-10-6278-1695 \u00a0 +86-10-6279-6197"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University a , Beijing 100084, China \u00a0 chen-yx@mail.tsinghua.edu.cn \u00a0 liym@mail.tsinghua.edu.cn \u00a0 +86-10-6278-1695 \u00a0 +86-10-6279-6197"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Fen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University a , Beijing 100084, China \u00a0 chen-yx@mail.tsinghua.edu.cn \u00a0 liym@mail.tsinghua.edu.cn \u00a0 +86-10-6278-1695 \u00a0 +86-10-6279-6197"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute for Brain Disorders b , Beijing 100069, China"},{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University a , Beijing 100084, China \u00a0 chen-yx@mail.tsinghua.edu.cn \u00a0 liym@mail.tsinghua.edu.cn \u00a0 +86-10-6278-1695 \u00a0 +86-10-6279-6197"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"key":"2026010815153963200_cit1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrn2194","volume":"8","author":"Ballatore","year":"2007","journal-title":"Nat. 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