{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:40:58Z","timestamp":1791207658105,"version":"4.1.0"},"reference-count":117,"publisher":"Royal Society of Chemistry (RSC)","issue":"8","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Med. Chem. Commun."],"abstract":"<p>The read-through mechanism of a premature stop codon.<\/p>","DOI":"10.1039\/c4md00081a","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T10:05:59Z","timestamp":1400234759000},"page":"1092-1105","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["When proteins start to make sense: fine-tuning of aminoglycosides for PTC suppression therapy"],"prefix":"10.1039","volume":"5","author":[{"given":"Moran","family":"Shalev","sequence":"first","affiliation":[{"name":"The Edith and Joseph Fischer Enzyme Inhibitors Laboratory"},{"name":"Schulich Faculty of Chemistry"},{"name":"Technion \u2013 Israel Institute of Technology"},{"name":"Haifa 32000"},{"name":"Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timor","family":"Baasov","sequence":"additional","affiliation":[{"name":"The Edith and Joseph Fischer Enzyme Inhibitors Laboratory"},{"name":"Schulich Faculty of Chemistry"},{"name":"Technion \u2013 Israel Institute of Technology"},{"name":"Haifa 32000"},{"name":"Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2014]]},"reference":[{"key":"C4MD00081A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1128\/MMBR.51.3.341-350.1987","volume":"51","author":"Davis","year":"1987","journal-title":"Microbiol. Rev."},{"key":"C4MD00081A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00253-005-0279-0","volume":"70","author":"Jana","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"C4MD00081A-(cit3)\/*[position()=1]","first-page":"1021","volume":"105","author":"Botto","year":"1993","journal-title":"Med. Chem."},{"key":"C4MD00081A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0022-2836(02)01452-3","volume":"326","author":"Kaul","year":"2003","journal-title":"J. Mol. Biol."},{"key":"C4MD00081A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/353368a0","volume":"353","author":"von","year":"1991","journal-title":"Nature"},{"key":"C4MD00081A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1017\/S1355838298981444","volume":"4","author":"Waldsich","year":"1998","journal-title":"RNA"},{"key":"C4MD00081A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.282.5387.296","volume":"282","author":"Werstuck","year":"1998","journal-title":"Science"},{"key":"C4MD00081A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14204","DOI":"10.1021\/bi981308u","volume":"37","author":"Mei","year":"1998","journal-title":"Biochemistry"},{"key":"C4MD00081A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0092-8674(93)90720-B","volume":"74","author":"Zapp","year":"1993","journal-title":"Cell"},{"key":"C4MD00081A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1073\/pnas.51.3.487","volume":"51","author":"Gorini","year":"1964","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4MD00081A-(cit11)\/*[position()=1]","unstructured":"OMIM, 2014, http:\/\/www.ncbi.nlm.nih.gov\/omim"},{"key":"C4MD00081A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/nar\/22.8.1327","volume":"22","author":"Atkinson","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"C4MD00081A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ejmg.2006.04.003","volume":"49","author":"Kellermayer","year":"2006","journal-title":"Eur. J. Med. Genet."},{"key":"C4MD00081A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3109\/10409238.2012.694846","volume":"47","author":"Keeling","year":"2012","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"C4MD00081A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.molmed.2012.09.008","volume":"18","author":"Bidou","year":"2012","journal-title":"Trends Mol. Med."},{"key":"C4MD00081A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1093\/nar\/13.17.6265","volume":"13","author":"Burke","year":"1985","journal-title":"Nucleic Acids Res."},{"key":"C4MD00081A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1172\/JCI8055","volume":"104","author":"Kaufman","year":"1999","journal-title":"J. Clin. Invest."},{"key":"C4MD00081A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.mcp.0000141247.22078.46","volume":"10","author":"Kerem","year":"2004","journal-title":"Curr. Opin. Pulm. Med."},{"key":"C4MD00081A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1017\/S1355838200000716","volume":"6","author":"Manuvakhova","year":"2000","journal-title":"RNA"},{"key":"C4MD00081A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1164\/ajrccm.161.3.9904116","volume":"161","author":"Wilschanski","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"C4MD00081A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1056\/NEJMoa022170","volume":"349","author":"Wilschanski","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"C4MD00081A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1177\/1756285610388693","volume":"3","author":"Malik","year":"2010","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"C4MD00081A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1172\/JCI7866","volume":"104","author":"Barton-Davis","year":"1999","journal-title":"J. Clin. Invest."},{"key":"C4MD00081A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/ana.22024","volume":"67","author":"Malik","year":"2010","journal-title":"Ann. Neurol."},{"key":"C4MD00081A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00109-010-0704-4","volume":"89","author":"Brendel","year":"2011","journal-title":"J. Mol. Med."},{"key":"C4MD00081A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e20733","DOI":"10.1371\/journal.pone.0020733","volume":"6","author":"Vecsler","year":"2011","journal-title":"PLoS One"},{"key":"C4MD00081A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/hmg\/10.3.291","volume":"10","author":"Keeling","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"C4MD00081A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/hmg\/ddh105","volume":"13","author":"Sangkuhl","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"C4MD00081A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/mgme.2001.3272","volume":"75","author":"Helip-Wooley","year":"2002","journal-title":"Mol. Genet. Metab."},{"key":"C4MD00081A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1093\/hmg\/11.24.3065","volume":"11","author":"Grayson","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"C4MD00081A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5660","DOI":"10.1021\/ja0318939","volume":"126","author":"Xi","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"C4MD00081A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/hmg\/ddi131","volume":"14","author":"Wolstencroft","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"C4MD00081A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.nbd.2012.06.013","volume":"48","author":"Huang","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"C4MD00081A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e24125","DOI":"10.1371\/journal.pone.0024125","volume":"6","author":"Floquet","year":"2011","journal-title":"PLoS One"},{"key":"C4MD00081A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1093\/nar\/gkq1277","volume":"39","author":"Floquet","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"C4MD00081A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/gut.2008.169805","volume":"59","author":"Zilberberg","year":"2010","journal-title":"Gut"},{"key":"C4MD00081A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1002608","DOI":"10.1371\/journal.pgen.1002608","volume":"8","author":"Floquet","year":"2012","journal-title":"PLoS Genet."},{"key":"C4MD00081A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/1531-8249(200008)48:2<164::AID-ANA5>3.0.CO;2-B","volume":"48","author":"Howard","year":"2000","journal-title":"Ann. Neurol."},{"key":"C4MD00081A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/ana.20052","volume":"55","author":"Howard","year":"2004","journal-title":"Ann. Neurol."},{"key":"C4MD00081A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/cbic.200300657","volume":"4","author":"Pfister","year":"2003","journal-title":"ChemBioChem"},{"key":"C4MD00081A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1093\/emboj\/18.11.3133","volume":"18","author":"Recht","year":"1999","journal-title":"EMBO J."},{"key":"C4MD00081A-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/anie.201006633","volume":"50","author":"Kondo","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"C4MD00081A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1073\/pnas.1307365110","volume":"110","author":"Shalev","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4MD00081A-(cit44)\/*[position()=1]","first-page":"125","volume":"884","author":"Schacht","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"C4MD00081A-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2133\/dmpk.19.159","volume":"19","author":"Nagai","year":"2004","journal-title":"Drug Metab. Pharmacokinet."},{"key":"C4MD00081A-(cit46)\/*[position()=1]","first-page":"14","volume":"1","author":"Kharkheli","year":"2007","journal-title":"Georgian Med. News"},{"key":"C4MD00081A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1525-139X.2012.01090.x","volume":"25","author":"Feldman","year":"2012","journal-title":"Semin. Dial."},{"key":"C4MD00081A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/labinvest.3780453","volume":"82","author":"Li","year":"2002","journal-title":"Lab. Invest."},{"key":"C4MD00081A-(cit49)\/*[position()=1]","first-page":"807","volume":"79","author":"Sha","year":"1999","journal-title":"Lab. Invest."},{"key":"C4MD00081A-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0378-5955(00)00003-4","volume":"142","author":"Sha","year":"2000","journal-title":"Hear. Res."},{"key":"C4MD00081A-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMc053428","volume":"354","author":"Sha","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"C4MD00081A-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0891-5849(98)00037-9","volume":"25","author":"Song","year":"1998","journal-title":"Free Radical Biol. Med."},{"key":"C4MD00081A-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0022-3565(25)23173-1","volume":"255","author":"Beauchamp","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"C4MD00081A-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/infdis\/159.5.945","volume":"159","author":"Gilbert","year":"1989","journal-title":"J. Infect. Dis."},{"key":"C4MD00081A-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1128\/AAC.38.5.1027","volume":"38","author":"Thibault","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"C4MD00081A-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/0024-3205(95)00162-Y","volume":"56","author":"Thibault","year":"1995","journal-title":"Life Sci."},{"key":"C4MD00081A-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.heares.2013.01.006","volume":"303","author":"Bottger","year":"2013","journal-title":"Hear. Res."},{"key":"C4MD00081A-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20888","DOI":"10.1073\/pnas.0811258106","volume":"105","author":"Hobbie","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4MD00081A-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10630","DOI":"10.1021\/jm3012992","volume":"55","author":"Kandasamy","year":"2012","journal-title":"J. Med. Chem."},{"key":"C4MD00081A-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1073\/pnas.1204073109","volume":"109","author":"Matt","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4MD00081A-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1523\/JNEUROSCI.3430-12.2013","volume":"33","author":"Francis","year":"2013","journal-title":"J. Neurosci."},{"key":"C4MD00081A-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1074\/jbc.M113.533588","volume":"289","author":"Shulman","year":"2013","journal-title":"J. Biol. Chem."},{"key":"C4MD00081A-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/cbic.200900779","volume":"11","author":"Houghton","year":"2010","journal-title":"ChemBioChem"},{"key":"C4MD00081A-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1038\/ncomms4112","volume":"5","author":"Perez-Fernandez","year":"2014","journal-title":"Nat. Commun."},{"key":"C4MD00081A-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1517\/17460441.2010.508069","volume":"5","author":"Pokrovskaya","year":"2010","journal-title":"Expert Opin. Drug Discovery"},{"key":"C4MD00081A-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1039\/c0md00195c","volume":"2","author":"Kandasamy","year":"2011","journal-title":"Med. Chem. Commun."},{"key":"C4MD00081A-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00439-006-0245-7","volume":"120","author":"Mattis","year":"2006","journal-title":"Hum. Genet."},{"key":"C4MD00081A-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6310","DOI":"10.1016\/j.bmcl.2006.09.013","volume":"16","author":"Nudelman","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C4MD00081A-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1021\/jm801640k","volume":"52","author":"Nudelman","year":"2009","journal-title":"J. Med. Chem."},{"key":"C4MD00081A-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1016\/j.bmc.2010.03.060","volume":"18","author":"Nudelman","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"C4MD00081A-(cit71)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1093\/hmg\/ddg256","volume":"12","author":"Brichta","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"C4MD00081A-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/ana.10743","volume":"54","author":"Sumner","year":"2003","journal-title":"Ann. Neurol."},{"key":"C4MD00081A-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1093\/hmg\/ddp333","volume":"18","author":"Mattis","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"C4MD00081A-(cit74)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2202-10-142","volume":"10","author":"Mattis","year":"2009","journal-title":"BMC Neurosci."},{"key":"C4MD00081A-(cit75)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1021\/ol0269042","volume":"4","author":"Chang","year":"2002","journal-title":"Org. Lett."},{"key":"C4MD00081A-(cit76)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00439-007-0410-7","volume":"122","author":"Rebibo-Sabbah","year":"2007","journal-title":"Hum. Genet."},{"key":"C4MD00081A-(cit77)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6671","DOI":"10.1167\/iovs.10-5741","volume":"51","author":"Goldmann","year":"2010","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"C4MD00081A-(cit78)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"677","DOI":"10.7164\/antibiotics.27.677","volume":"27","author":"Fujisawa","year":"1974","journal-title":"J. Antibiot."},{"key":"C4MD00081A-(cit79)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s101560050001","volume":"5","author":"Kondo","year":"1999","journal-title":"J. Infect. Chemother."},{"key":"C4MD00081A-(cit80)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s00109-011-0787-6","volume":"89","author":"Rowe","year":"2011","journal-title":"J. Mol. Med."},{"key":"C4MD00081A-(cit81)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ymgme.2011.10.005","volume":"105","author":"Wang","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"C4MD00081A-(cit82)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.ymgme.2013.12.106","volume":"111","author":"Gunn","year":"2014","journal-title":"Mol. Genet. Metab."},{"key":"C4MD00081A-(cit83)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1165\/rcmb.2013-0282OC","volume":"50","author":"Xue","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"C4MD00081A-(cit84)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/cbic.200700271","volume":"8","author":"Kondo","year":"2007","journal-title":"ChemBioChem"},{"key":"C4MD00081A-(cit85)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ab.2011.01.013","volume":"412","author":"Kythreoti","year":"2011","journal-title":"Anal. Biochem."},{"key":"C4MD00081A-(cit86)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bcmd.2006.11.006","volume":"38","author":"Hermann","year":"2007","journal-title":"Blood Cells, Mol., Dis."},{"key":"C4MD00081A-(cit87)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/cbic.200300689","volume":"4","author":"Simonsen","year":"2003","journal-title":"ChemBioChem"},{"key":"C4MD00081A-(cit88)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/cbic.200300688","volume":"4","author":"Vourloumis","year":"2003","journal-title":"ChemBioChem"},{"key":"C4MD00081A-(cit89)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/wrna.95","volume":"2","author":"Keeling","year":"2011","journal-title":"Wiley Interdiscip. Rev.: RNA"},{"key":"C4MD00081A-(cit90)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature05756","volume":"447","author":"Welch","year":"2007","journal-title":"Nature"},{"key":"C4MD00081A-(cit91)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1177\/0091270006297140","volume":"47","author":"Hirawat","year":"2007","journal-title":"J. Clin. Pharmacol."},{"key":"C4MD00081A-(cit93)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1073\/pnas.0813345106","volume":"106","author":"Auld","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4MD00081A-(cit94)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1073\/pnas.0909141107","volume":"107","author":"Auld","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4MD00081A-(cit95)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1172\/JCI70462","volume":"124","author":"Gregory-Evans","year":"2014","journal-title":"J. Clin. Invest."},{"key":"C4MD00081A-(cit96)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/emmm.201201438","volume":"4","author":"Goldmann","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"C4MD00081A-(cit97)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/mt.2013.150","volume":"21","author":"Du","year":"2013","journal-title":"Mol. Ther."},{"key":"C4MD00081A-(cit98)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1128\/AAC.00455-07","volume":"51","author":"Schroeder","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"C4MD00081A-(cit99)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/jb\/mvg203","volume":"134","author":"Arakawa","year":"2003","journal-title":"J. Biochem."},{"key":"C4MD00081A-(cit100)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1038\/emboj.2010.139","volume":"29","author":"Korostelev","year":"2010","journal-title":"EMBO J."},{"key":"C4MD00081A-(cit101)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nature07115","volume":"454","author":"Laurberg","year":"2008","journal-title":"Nature"},{"key":"C4MD00081A-(cit102)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8593","DOI":"10.1073\/pnas.1003995107","volume":"107","author":"Jin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4MD00081A-(cit103)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cell.2005.09.039","volume":"123","author":"Petry","year":"2005","journal-title":"Cell"},{"key":"C4MD00081A-(cit104)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1126\/science.1164840","volume":"322","author":"Weixlbaumer","year":"2008","journal-title":"Science"},{"key":"C4MD00081A-(cit105)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1126\/science.1060612","volume":"292","author":"Ogle","year":"2001","journal-title":"Science"},{"key":"C4MD00081A-(cit106)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nsmb1271","volume":"14","author":"Borovinskaya","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C4MD00081A-(cit107)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.jmb.2007.12.048","volume":"376","author":"Pai","year":"2008","journal-title":"J. Mol. Biol."},{"key":"C4MD00081A-(cit108)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1093\/nar\/21.9.2109","volume":"21","author":"Brown","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"C4MD00081A-(cit109)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.molcel.2007.09.015","volume":"28","author":"Youngman","year":"2007","journal-title":"Mol. Cell"},{"key":"C4MD00081A-(cit110)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nature10913","volume":"484","author":"Demeshkina","year":"2012","journal-title":"Nature"},{"key":"C4MD00081A-(cit111)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1126\/science.1194294","volume":"330","author":"Ben-Shem","year":"2010","journal-title":"Science"},{"key":"C4MD00081A-(cit112)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1212642","volume":"334","author":"Ben-Shem","year":"2011","journal-title":"Science"},{"key":"C4MD00081A-(cit113)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.1211204","volume":"334","author":"Klinge","year":"2011","journal-title":"Science"},{"key":"C4MD00081A-(cit114)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1126\/science.1198308","volume":"331","author":"Rabl","year":"2011","journal-title":"Science"},{"key":"C4MD00081A-(cit115)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature12355","volume":"500","author":"Lomakin","year":"2013","journal-title":"Nature"},{"key":"C4MD00081A-(cit116)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1002\/anie.200600354","volume":"45","author":"Kondo","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"C4MD00081A-(cit117)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1750-1172-7-58","volume":"7","author":"Gonzalez-Hilarion","year":"2012","journal-title":"Orphanet J. Rare Dis."},{"issue":"4","key":"C4MD00081A-(cit118)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4172\/1948-593X.1000086","volume":"5","author":"Loudon","year":"2013","journal-title":"J. Bioanal. Biomed."}],"container-title":["MedChemComm"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2014\/MD\/C4MD00081A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:18:33Z","timestamp":1783448313000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/1m\/article\/5\/8\/1092-1105\/440987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":117,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,7,23]]}},"URL":"https:\/\/doi.org\/10.1039\/c4md00081a","relation":{},"ISSN":["2040-2503","2040-2511"],"issn-type":[{"value":"2040-2503","type":"print"},{"value":"2040-2511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"This document is CrossCheck deposited","name":"crosscheck","explanation":{"URL":"http:\/\/www.crossref.org\/crosscheck\/index.html"},"group":{"name":"crosscheck","label":"CROSSCHECK"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Received 24 February 2014; Accepted 16 May 2014; Accepted Manuscript published 16 May 2014; Advance Article published 27 June 2014; Version of Record published 23 July 2014","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}