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B"},{"key":"C4MT00066H-(cit63c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/jcc.10157","volume":"23","author":"Suarez","year":"2002","journal-title":"J. Comput. Chem."},{"key":"C4MT00066H-(cit64a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1021\/jp068746s","volume":"111","author":"Xu","year":"2007","journal-title":"J. Phys. Chem. A"},{"key":"C4MT00066H-(cit64b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10814","DOI":"10.1021\/ja072532m","volume":"129","author":"Xu","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"C4MT00066H-(cit64c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10822-012-9630-6","volume":"27","author":"Zhu","year":"2013","journal-title":"J. Comput.-Aided Mol. 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Appl."},{"key":"C4MT00066H-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1007\/s000180200013","volume":"59","author":"Prosperi-Meys","year":"2002","journal-title":"Cell. Mol. 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B"},{"key":"C4MT00066H-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1021\/ja042607b","volume":"127","author":"Park","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"C4MT00066H-(cit74a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2091-3-4","volume":"3","author":"Carenbauer","year":"2002","journal-title":"BMC Biochem."},{"key":"C4MT00066H-(cit74b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"33630","DOI":"10.1074\/jbc.M403671200","volume":"279","author":"Mercuri","year":"2004","journal-title":"J. Biol. Chem."},{"key":"C4MT00066H-(cit74c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11330","DOI":"10.1021\/bi0010524","volume":"39","author":"Yanchak","year":"2000","journal-title":"Biochemistry"},{"key":"C4MT00066H-(cit75a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1042\/bj3630687","volume":"363","author":"de Seny","year":"2002","journal-title":"Biochem. J."},{"key":"C4MT00066H-(cit75b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18276","DOI":"10.1074\/jbc.M700742200","volume":"282","author":"Llarrull","year":"2007","journal-title":"J. Biol. Chem."},{"key":"C4MT00066H-(cit76)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13761","DOI":"10.1073\/pnas.0503495102","volume":"102","author":"Tomatis","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4MT00066H-(cit77a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10788","DOI":"10.1021\/ja982621m","volume":"120","author":"Wang","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"C4MT00066H-(cit77b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10013","DOI":"10.1021\/bi990356r","volume":"38","author":"Wang","year":"1999","journal-title":"Biochemistry"},{"key":"C4MT00066H-(cit77c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1021\/bi9826512","volume":"38","author":"McManus-Munoz","year":"1999","journal-title":"Biochemistry"},{"key":"C4MT00066H-(cit78)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11642","DOI":"10.1021\/ja902534b","volume":"131","author":"Breece","year":"2009","journal-title":"J. Am. Chem. 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