{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:41:54Z","timestamp":1782934914712,"version":"3.54.5"},"reference-count":73,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nat. Prod. Rep."],"abstract":"<p>This highlight focuses on the marine natural products that target cytoskeletal proteins and modulate protein\u2013protein interactions in unique fashions.<\/p>","DOI":"10.1039\/c4np00129j","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T06:33:08Z","timestamp":1418711588000},"page":"534-542","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Marine natural products that interfere with multiple cytoskeletal protein interactions"],"prefix":"10.1039","volume":"32","author":[{"given":"Masaki","family":"Kita","sequence":"first","affiliation":[{"name":"Graduate School of Pure and Applied Sciences"},{"name":"University of Tsukuba"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Kigoshi","sequence":"additional","affiliation":[{"name":"Graduate School of Pure and Applied Sciences"},{"name":"University of Tsukuba"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C4NP00129J-(cit1)\/*[position()=1]","volume-title":"Chemical Biology: Learning through Case Studies","author":"Bovens","year":"2009","unstructured":"S. Bovens and C.Ottmann, in Chemical Biology: Learning through Case Studies, ed. H. Waldmann and P. Jannig, Wiley-VCH Verlag GmbH, Weinheim, 2009, pp. 105\u2013119"},{"key":"C4NP00129J-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1126\/science.7694365","volume":"262","author":"Spencer","year":"1993","journal-title":"Science"},{"key":"C4NP00129J-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/nature06526","volume":"450","author":"Wells","year":"2007","journal-title":"Nature"},{"key":"C4NP00129J-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1021\/cr400698c","volume":"114","author":"Milroy","year":"2014","journal-title":"Chem. Rev."},{"key":"C4NP00129J-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"C4NP00129J-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3253","volume":"9","author":"Dumontet","year":"2010","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C4NP00129J-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1021\/np800568j","volume":"72","author":"Kingston","year":"2009","journal-title":"J. Nat. Prod."},{"key":"C4NP00129J-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1039\/c3np70051h","volume":"30","author":"Yu","year":"2013","journal-title":"Nat. Prod. Rep."},{"key":"C4NP00129J-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0140-6736(11)60070-6","volume":"377","author":"Cortes","year":"2011","journal-title":"Lancet"},{"key":"C4NP00129J-(cit10)\/*[position()=1]","volume-title":"International oncology updates: marine anticancer compounds in the era of targeted therapies","author":"Pettit","year":"2009","unstructured":"G. R. Pettit , in International oncology updates: marine anticancer compounds in the era of targeted therapies, ed. B. Chabner and H. Cortes\u2013Funes, Permanyer, Barcelona, 2009, pp. 19\u201350"},{"key":"C4NP00129J-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1182\/blood-2003-01-0039","volume":"102","author":"Francisco","year":"2003","journal-title":"Blood"},{"key":"C4NP00129J-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1152\/physrev.00026.2002","volume":"83","author":"dos Remedios","year":"2003","journal-title":"Physiol. Rev."},{"key":"C4NP00129J-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1002\/anie.200290057","volume":"41","author":"Yeung","year":"2002","journal-title":"Angew. Chem., Int. Ed."},{"key":"C4NP00129J-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2174\/1568026033452348","volume":"3","author":"Fenteany","year":"2003","journal-title":"Curr. Top. Med. Chem."},{"key":"C4NP00129J-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1007\/s00018-006-6157-9","volume":"63","author":"Allingham","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"C4NP00129J-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.6681676","volume":"219","author":"Spector","year":"1983","journal-title":"Science"},{"key":"C4NP00129J-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00018-007-6427-1","volume":"64","author":"Vincent","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"C4NP00129J-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"29710","DOI":"10.1016\/S0021-9258(18)43938-5","volume":"269","author":"Saito","year":"1994","journal-title":"J. Biol. Chem."},{"key":"C4NP00129J-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13851","DOI":"10.1073\/pnas.2233339100","volume":"100","author":"Tanaka","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4NP00129J-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.chembiol.2008.01.010","volume":"15","author":"Perrins","year":"2008","journal-title":"Chem. Biol."},{"key":"C4NP00129J-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nchembio748","volume":"1","author":"Statsuk","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"C4NP00129J-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1073\/pnas.0710727105","volume":"105","author":"Rizvi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4NP00129J-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1074\/jbc.274.7.4259","volume":"274","author":"Posey","year":"1999","journal-title":"J. Biol. Chem."},{"key":"C4NP00129J-(cit24)\/*[position()=1]","first-page":"2091","volume":"29","author":"Konishi","year":"2009","journal-title":"Anticancer Res."},{"key":"C4NP00129J-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.bmcl.2012.12.052","volume":"23","author":"Ohno","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C4NP00129J-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/nsb1006","volume":"10","author":"Klenchin","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"C4NP00129J-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jmb.2005.12.031","volume":"356","author":"Hirata","year":"2006","journal-title":"J. Mol. Biol."},{"key":"C4NP00129J-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14527","DOI":"10.1073\/pnas.0502089102","volume":"102","author":"Allingham","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4NP00129J-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.chembiol.2005.02.011","volume":"12","author":"Klenchin","year":"2005","journal-title":"Chem. Biol."},{"key":"C4NP00129J-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1021\/ja058319c","volume":"128","author":"Rizvi","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"C4NP00129J-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1248\/cpb.38.2960","volume":"38","author":"Kobayashi","year":"1990","journal-title":"Chem. Pharm. Bull."},{"key":"C4NP00129J-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1074\/jbc.270.8.3463","volume":"270","author":"Bubb","year":"1995","journal-title":"J. Biol. Chem."},{"key":"C4NP00129J-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1248\/cpb.38.2967","volume":"38","author":"Tanaka","year":"1990","journal-title":"Chem. Pharm. Bull."},{"key":"C4NP00129J-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/oxfordjournals.jbchem.a021975","volume":"123","author":"Saito","year":"1998","journal-title":"J. Biochem."},{"key":"C4NP00129J-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"741","DOI":"10.7164\/antibiotics.46.741","volume":"46","author":"Sasse","year":"1993","journal-title":"J. Antibiot."},{"key":"C4NP00129J-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5796","DOI":"10.1016\/j.tetlet.2008.07.132","volume":"49","author":"Jansen","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"C4NP00129J-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.1039\/b810405k","author":"Horstmann","year":"2008","journal-title":"Chem. Commun."},{"key":"C4NP00129J-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/anie.200802915","volume":"48","author":"Hagelueken","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"C4NP00129J-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6916","DOI":"10.1073\/pnas.1131855100","volume":"100","author":"Kubanek","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4NP00129J-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.chembiol.2010.06.010","volume":"17","author":"Blain","year":"2010","journal-title":"Chem. Biol."},{"key":"C4NP00129J-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/35024000","volume":"407","author":"Sharp","year":"2000","journal-title":"Nature"},{"key":"C4NP00129J-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nrm2774","volume":"10","author":"Hirokawa","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C4NP00129J-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.280.5361.292","volume":"280","author":"Sakowicz","year":"1998","journal-title":"Science"},{"key":"C4NP00129J-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15644","DOI":"10.1021\/bi061395n","volume":"45","author":"Brier","year":"2006","journal-title":"Biochemistry"},{"key":"C4NP00129J-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8429","DOI":"10.1016\/S0040-4020(00)00786-9","volume":"56","author":"Blackburn","year":"2000","journal-title":"Tetrahedron"},{"key":"C4NP00129J-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.286.5441.971","volume":"286","author":"Mayer","year":"1999","journal-title":"Science"},{"key":"C4NP00129J-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1074-5521(03)00020-6","volume":"10","author":"Nakazawa","year":"2003","journal-title":"Chem. Biol."},{"key":"C4NP00129J-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1021\/bi992474k","volume":"39","author":"Hopkins","year":"2000","journal-title":"Biochemistry"},{"key":"C4NP00129J-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jmb.2003.10.074","volume":"335","author":"Yan","year":"2004","journal-title":"J. Mol. Biol."},{"key":"C4NP00129J-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18880","DOI":"10.1073\/pnas.1314132110","volume":"110","author":"Smith","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4NP00129J-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1246\/bcsj.70.1479","volume":"70","author":"Yamada","year":"1997","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"C4NP00129J-(cit52)\/*[position()=1]","first-page":"701","volume-title":"Handbook of Anticancer Drugs from Marine Origin","author":"Kita","year":"2015","unstructured":"M. Kita and H.Kigoshi, in Handbook of Anticancer Drugs from Marine Origin, ed. S. -K. Kim, Springer, 2015, pp. 701740"},{"key":"C4NP00129J-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11020","DOI":"10.1021\/ja00076a082","volume":"115","author":"Yamada","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"C4NP00129J-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.1021\/ja00095a071","volume":"116","author":"Ojika","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"C4NP00129J-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1021\/ja00095a072","volume":"116","author":"Kigoshi","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"C4NP00129J-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1021\/jo9606113","volume":"61","author":"Kigoshi","year":"1996","journal-title":"J. Org. Chem."},{"key":"C4NP00129J-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1021\/ol401327r","volume":"15","author":"Paterson","year":"2013","journal-title":"Org. Lett."},{"key":"C4NP00129J-(cit58)\/*[position()=1]","volume-title":"Drugs from the Sea","author":"Yamada","year":"2000","unstructured":"K. Yamada , M.Ojika, H.Kigoshi, and K.Suenaga, in Drugs from the Sea, ed. N. Fusetani, Karger, Basel, 2000, pp. 59\u201373"},{"key":"C4NP00129J-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2183\/pjab.86.176","volume":"86","author":"Yamada","year":"2010","journal-title":"Proc. Jpn. Acad., Ser. B"},{"key":"C4NP00129J-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1039\/B800263K","volume":"26","author":"Yamada","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"C4NP00129J-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/oxfordjournals.jbchem.a021449","volume":"120","author":"Saito","year":"1996","journal-title":"J. Biochem."},{"key":"C4NP00129J-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0960-894X(96)00620-8","volume":"7","author":"Suenaga","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C4NP00129J-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0040-4020(01)01206-6","volume":"58","author":"Kigoshi","year":"2002","journal-title":"Tetrahedron"},{"key":"C4NP00129J-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1021\/bc050324i","volume":"17","author":"Kuroda","year":"2006","journal-title":"Bioconjugate Chem."},{"key":"C4NP00129J-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/cbic.201200385","volume":"13","author":"Kita","year":"2012","journal-title":"ChemBioChem"},{"key":"C4NP00129J-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9871","DOI":"10.1002\/anie.201103802","volume":"50","author":"Kita","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"C4NP00129J-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20314","DOI":"10.1021\/ja310495p","volume":"134","author":"Kita","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"C4NP00129J-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18089","DOI":"10.1021\/ja406580w","volume":"135","author":"Kita","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"C4NP00129J-(cit69)\/*[position()=1]","first-page":"2212","volume":"51","author":"Jordan","year":"1991","journal-title":"Cancer Res."},{"key":"C4NP00129J-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9552","DOI":"10.1073\/pnas.90.20.9552","volume":"90","author":"Jordan","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4NP00129J-(cit71)\/*[position()=1]","first-page":"816","volume":"56","author":"Jordan","year":"1996","journal-title":"Cancer Res."},{"key":"C4NP00129J-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/ncb0703-599","volume":"5","author":"Rodriguez","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"C4NP00129J-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1246\/cl.2012.658","volume":"41","author":"Ueda","year":"2012","journal-title":"Chem. Lett."}],"container-title":["Natural Product Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/NP\/C4NP00129J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:52:52Z","timestamp":1782928372000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/np\/article\/32\/4\/534-542\/442572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c4np00129j","relation":{},"ISSN":["0265-0568","1460-4752"],"issn-type":[{"value":"0265-0568","type":"print"},{"value":"1460-4752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 2 October 2014; Advance Article published 16 December 2014; Version of Record published 25 March 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}