{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:46:56Z","timestamp":1782967616630,"version":"3.54.5"},"reference-count":25,"publisher":"Royal Society of Chemistry (RSC)","issue":"25","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>\n                    Hybrid\n                    <bold>5f<\/bold>\n                    significantly inhibited both Ras-related signaling and phosphorylated NF-\u03baB, which may synergistically contribute to its apoptosis induction and tumor growth inhibition\n                    <italic>in vitro<\/italic>\n                    and\n                    <italic>in vivo<\/italic>\n                    .\n                  <\/p>","DOI":"10.1039\/c4ob00023d","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T05:02:37Z","timestamp":1398402157000},"page":"4517-4530","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis and biological evaluation of hybrids from farnesylthiosalicylic acid and hydroxylcinnamic acid with dual inhibitory activities of Ras-related signaling and phosphorylated NF-\u03baB"],"prefix":"10.1039","volume":"12","author":[{"given":"Yong","family":"Ling","sequence":"first","affiliation":[{"name":"School of Pharmacy"},{"name":"Nantong University"},{"name":"Nantong"},{"name":"PR China"},{"name":"State Key Laboratory of Natural Medicines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy"},{"name":"Nantong University"},{"name":"Nantong"},{"name":"PR China"},{"name":"State Key Laboratory of Natural Medicines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy"},{"name":"Nantong University"},{"name":"Nantong"},{"name":"PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy"},{"name":"Nantong University"},{"name":"Nantong"},{"name":"PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy"},{"name":"Nantong University"},{"name":"Nantong"},{"name":"PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy"},{"name":"Nantong University"},{"name":"Nantong"},{"name":"PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines"},{"name":"China Pharmaceutical University"},{"name":"Nanjing"},{"name":"PR China"},{"name":"Center of Drug Discovery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangjian","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines"},{"name":"China Pharmaceutical University"},{"name":"Nanjing"},{"name":"PR China"},{"name":"Center of Drug Discovery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines"},{"name":"China Pharmaceutical University"},{"name":"Nanjing"},{"name":"PR China"},{"name":"Center of Drug Discovery"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2014]]},"reference":[{"key":"C4OB00023D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1126\/science.1062023","volume":"294","author":"Vetter","year":"2001","journal-title":"Science"},{"key":"C4OB00023D-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1242\/jcs.01660","volume":"118","author":"Wennerberg","year":"2005","journal-title":"J. Cell Sci."},{"key":"C4OB00023D-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1126\/science.277.5324.333","volume":"277","author":"Scheffzek","year":"1997","journal-title":"Science"},{"key":"C4OB00023D-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc969","volume":"3","author":"Downward","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"C4OB00023D-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1164368","volume":"321","author":"Jones","year":"2008","journal-title":"Science"},{"key":"C4OB00023D-(cit6)\/*[position()=1]","volume-title":"Robbins and Cotran Pathologic Basis of Disease (Professional Edition)","author":"Kumar","year":"2010","unstructured":"V. Kumar  ,  A. K.Abbas ,  N.Fausto  and  J. C.Aster ,  Robbins and Cotran Pathologic Basis of Disease (Professional Edition) ,  Saunders ,  PA, USA ,  2010"},{"key":"C4OB00023D-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/jnci\/93.14.1062","volume":"93","author":"Adjei","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"C4OB00023D-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/22788","volume":"400","author":"Chin","year":"1999","journal-title":"Nature"},{"key":"C4OB00023D-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S160","DOI":"10.1097\/JTO.0b013e318174dbf9","volume":"3","author":"Adjei","year":"2008","journal-title":"J. Thorac. Oncol."},{"key":"C4OB00023D-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/1476-4598-9-256","volume":"9","author":"Charette1","year":"2010","journal-title":"Mol. Cancer"},{"key":"C4OB00023D-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e471","DOI":"10.1038\/cddis.2012.200","volume":"4","author":"Charette","year":"2013","journal-title":"Cell Death Dis."},{"key":"C4OB00023D-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s10637-012-9818-6","volume":"30","author":"Laheru","year":"2012","journal-title":"Invest. New Drugs"},{"key":"C4OB00023D-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/01.cad.0000185184.64980.39","volume":"17","author":"Santen","year":"2006","journal-title":"Anticancer Drugs"},{"key":"C4OB00023D-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"22263","DOI":"10.1074\/jbc.270.38.22263","volume":"270","author":"Marom","year":"1995","journal-title":"J. Biol. Chem."},{"key":"C4OB00023D-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2217\/fon.10.71","volume":"6","author":"Bustinza-Linares","year":"2010","journal-title":"Future Oncol."},{"key":"C4OB00023D-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ejps.2012.01.010","volume":"45","author":"Kim","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"C4OB00023D-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1021\/tx200126r","volume":"24","author":"Serafim","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"C4OB00023D-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1021\/jf203807w","volume":"60","author":"Whent","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"C4OB00023D-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/med.20060","volume":"26","author":"Fresco","year":"2006","journal-title":"Med. Res. Rev."},{"key":"C4OB00023D-(cit20)\/*[position()=1]","first-page":"3","volume":"1","author":"Serafim","year":"2008","journal-title":"J. Theor. Exp. Pharm."},{"key":"C4OB00023D-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10863-007-9097-7","volume":"40","author":"Cione","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"key":"C4OB00023D-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1126\/science.278.5344.1812","volume":"278","author":"Mayo","year":"1997","journal-title":"Science"},{"key":"C4OB00023D-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/43474","volume":"401","author":"Romashkova","year":"1999","journal-title":"Nature"},{"key":"C4OB00023D-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10522-008-9160-8","volume":"10","author":"Barone","year":"2009","journal-title":"Biogerontology"},{"key":"C4OB00023D-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bmc.2013.11.013","volume":"22","author":"Ling","year":"2014","journal-title":"Bioorg. Med. Chem."}],"updated-by":[{"DOI":"10.1039\/d0ob90173c","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000}}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2014\/OB\/C4OB00023D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:45:13Z","timestamp":1782963913000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/12\/25\/4517-4530\/444580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":25,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2014,6,4]]}},"URL":"https:\/\/doi.org\/10.1039\/c4ob00023d","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"This document is CrossCheck deposited","name":"crosscheck","explanation":{"URL":"http:\/\/www.crossref.org\/crosscheck\/index.html"},"group":{"name":"crosscheck","label":"CROSSCHECK"}},{"value":"Supplementary Information","URL":"http:\/\/dx.doi.org\/10.1039\/C4OB00023D","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Received 4 January 2014; Accepted 24 April 2014;  Accepted Manuscript published 25 April 2014;  Advance Article published 22 May 2014;  Version of Record published 4 June 2014","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}