{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:31:56Z","timestamp":1782934316402,"version":"3.54.5"},"reference-count":20,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>A His-tagged antibody is combined with an NTA-\u03b2-sheet breaker and displays a striking increase in A\u03b2 affinity.<\/p>","DOI":"10.1039\/c4ob02411g","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T06:03:51Z","timestamp":1421129031000},"page":"2974-2979","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hybridization of an A\u03b2-specific antibody fragment with aminopyrazole-based \u03b2-sheet ligands displays striking enhancement of target affinity"],"prefix":"10.1039","volume":"13","author":[{"given":"Marco","family":"Hellmert","sequence":"first","affiliation":[{"name":"Institute for Organic Chemistry"},{"name":"University of Duisburg-Essen"},{"name":"45117 Essen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"M\u00fcller-Schiffmann","sequence":"additional","affiliation":[{"name":"Department of Neuropathology"},{"name":"Heinrich Heine University"},{"name":"40225 D\u00fcsseldorf"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max Sena","family":"Peters","sequence":"additional","affiliation":[{"name":"Institute for Organic Chemistry"},{"name":"University of Duisburg-Essen"},{"name":"45117 Essen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Korth","sequence":"additional","affiliation":[{"name":"Department of Neuropathology"},{"name":"Heinrich Heine University"},{"name":"40225 D\u00fcsseldorf"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schrader","sequence":"additional","affiliation":[{"name":"Institute for Organic Chemistry"},{"name":"University of Duisburg-Essen"},{"name":"45117 Essen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C4OB02411G-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"C4OB02411G-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1021\/cr3000994","volume":"112","author":"Hamley","year":"2012","journal-title":"Chem. Rev."},{"key":"C4OB02411G-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4161\/pri.22118","volume":"7","author":"Nussbaum","year":"2013","journal-title":"Prion"},{"key":"C4OB02411G-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23063","DOI":"10.1074\/jbc.M111.237974","volume":"286","author":"Patterson","year":"2011","journal-title":"J. Biol. Chem."},{"key":"C4OB02411G-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C4OB02411G-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3233\/JAD-2010-1332","volume":"19","author":"Kim","year":"2010","journal-title":"J. Alzheimer's Dis."},{"key":"C4OB02411G-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00019052-200404000-00003","volume":"17","author":"Head","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"key":"C4OB02411G-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.bpj.2011.02.023","volume":"100","author":"Kagan","year":"2011","journal-title":"Biophys. J."},{"key":"C4OB02411G-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e9505","DOI":"10.1371\/journal.pone.0009505","volume":"5","author":"Soscia","year":"2010","journal-title":"PLoS One"},{"key":"C4OB02411G-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34882","DOI":"10.1074\/jbc.M300825200","volume":"278","author":"Bitan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"C4OB02411G-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1039\/CC9960002089","author":"Schrader","year":"1996","journal-title":"Chem. Commun."},{"key":"C4OB02411G-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12061","DOI":"10.1021\/ja972158y","volume":"119","author":"Kirsten","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"C4OB02411G-(cit13)\/*[position()=1]","first-page":"1815","author":"Rzepecki","year":"2003","journal-title":"Synthesis"},{"key":"C4OB02411G-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1021\/ja107675n","volume":"133","author":"Hochd\u00f6rffer","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C4OB02411G-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8743","DOI":"10.1002\/anie.201004437","volume":"49","author":"M\u00fcller-Schiffmann","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"C4OB02411G-(cit16)\/*[position()=1]","first-page":"628070","author":"Lobello","year":"2012","journal-title":"Int. J. Alzheimer's Dis."},{"key":"C4OB02411G-(cit17)\/*[position()=1]","first-page":"188","volume":"10","author":"Wang","year":"2014","journal-title":"Nat. Rev."},{"key":"C4OB02411G-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e59820","DOI":"10.1371\/journal.pone.0059820","volume":"8","author":"Dornieden","year":"2013","journal-title":"PLoS One"},{"key":"C4OB02411G-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10205","DOI":"10.1021\/ja050690c","volume":"127","author":"Lata","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"C4OB02411G-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18202","DOI":"10.1021\/ja907066r","volume":"131","author":"Heeres","year":"2009","journal-title":"J. Am. Chem. Soc."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/OB\/C4OB02411G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:46:10Z","timestamp":1782927970000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/13\/10\/2974-2979\/445641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c4ob02411g","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C4OB02411G","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)","URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 15 November 2014; Accepted 13 January 2015;  Accepted Manuscript published 13 January 2015;  Advance Article published 23 January 2015;  Version of Record published 24 February 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}