{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:50:12Z","timestamp":1782885012542,"version":"3.54.5"},"reference-count":61,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<p>A bifunctional Ca\u2013Mg\u2013Si bioceramic induces osteogenic differentiation of gingival fibroblasts and inhibits plaque biofilm formation.<\/p>","DOI":"10.1039\/c5bm00534e","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T04:30:21Z","timestamp":1453696221000},"page":"639-651","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bifunctional bioceramics stimulating osteogenic differentiation of a gingival fibroblast and inhibiting plaque biofilm formation"],"prefix":"10.1039","volume":"4","author":[{"given":"Ya","family":"Shen","sequence":"first","affiliation":[{"name":"Division of Endodontics"},{"name":"Oral Biological & Medical Sciences"},{"name":"School of Dentistry"},{"name":"University of British Columbia"},{"name":"Vancouver BC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhejun","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Endodontics"},{"name":"Oral Biological & Medical Sciences"},{"name":"School of Dentistry"},{"name":"University of British Columbia"},{"name":"Vancouver BC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neural Biology"},{"name":"School of Life Sciences"},{"name":"Shanghai University"},{"name":"Shanghai 200444"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Health & Biomedical Innovation"},{"name":"Queensland University of Technology"},{"name":"Brisbane"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontics"},{"name":"Affiliated Hospital of Stomatology"},{"name":"Medical College"},{"name":"Zhejiang University"},{"name":"Hangzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengtie","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure"},{"name":"Shanghai Institute of Ceramics"},{"name":"Chinese Academy of Sciences"},{"name":"Shanghai 200050"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Haapasalo","sequence":"additional","affiliation":[{"name":"Division of Endodontics"},{"name":"Oral Biological & Medical Sciences"},{"name":"School of Dentistry"},{"name":"University of British Columbia"},{"name":"Vancouver BC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C5BM00534E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1902\/jop.2012.120529","volume":"84","author":"Koseoglu","year":"2013","journal-title":"J. Periodontol."},{"key":"C5BM00534E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1902\/jop.2010.090540","volume":"81","author":"Chambrone","year":"2010","journal-title":"J. Periodontol."},{"key":"C5BM00534E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1902\/jop.2012.110373","volume":"83","author":"McGuire","year":"2012","journal-title":"J. Periodontol."},{"issue":"Suppl 15","key":"C5BM00534E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1111\/jcpe.12182","volume":"41","author":"Cairo","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"C5BM00534E-(cit5)\/*[position()=1]","first-page":"e238","volume":"59","author":"Henriques","year":"2011","journal-title":"Gen. Dent."},{"key":"C5BM00534E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1902\/jop.2007.060170","volume":"78","author":"Shin","year":"2007","journal-title":"J. Periodontol."},{"key":"C5BM00534E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.dental.2014.07.007","volume":"30","author":"Peumans","year":"2014","journal-title":"Dent. Mater."},{"key":"C5BM00534E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.dental.2006.10.005","volume":"23","author":"van Dijken","year":"2007","journal-title":"Dent. Mater."},{"key":"C5BM00534E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.biomaterials.2012.09.066","volume":"34","author":"Wu","year":"2013","journal-title":"Biomaterials"},{"key":"C5BM00534E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1039\/C2BM00071G","volume":"1","author":"Salinas","year":"2013","journal-title":"Biomater. Sci."},{"key":"C5BM00534E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/j.actbio.2012.03.012","volume":"8","author":"Zhou","year":"2012","journal-title":"Acta Biomater."},{"key":"C5BM00534E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.actbio.2008.04.014","volume":"4","author":"Ramaswamy","year":"2008","journal-title":"Acta Biomater."},{"key":"C5BM00534E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.actbio.2009.12.022","volume":"6","author":"Wu","year":"2010","journal-title":"Acta Biomater."},{"key":"C5BM00534E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1039\/C4BM00111G","volume":"2","author":"Han","year":"2014","journal-title":"Biomater. Sci."},{"key":"C5BM00534E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1039\/c3bm60028a","volume":"1","author":"Xu","year":"2013","journal-title":"Biomater. Sci."},{"key":"C5BM00534E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1834-7819.2011.01361.x","volume":"56","author":"Wang","year":"2011","journal-title":"Aust. Dent. J."},{"key":"C5BM00534E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3892\/ijmm.2014.1986","volume":"35","author":"Choi","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"C5BM00534E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.archoralbio.2013.04.002","volume":"58","author":"Willershausen","year":"2013","journal-title":"Arch. Oral. Biol."},{"key":"C5BM00534E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.joen.2011.02.029","volume":"37","author":"Ma","year":"2011","journal-title":"J. Endod."},{"key":"C5BM00534E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.joen.2014.09.012","volume":"41","author":"Zhou","year":"2015","journal-title":"J. Endod."},{"key":"C5BM00534E-(cit21)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12248","author":"Ji","year":"2014","journal-title":"J. Periodontal. Res."},{"key":"C5BM00534E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.dental.2013.12.001","volume":"30","author":"Wang","year":"2014","journal-title":"Dent. Mater."},{"key":"C5BM00534E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.joen.2013.10.042","volume":"40","author":"Wang","year":"2014","journal-title":"J. Endod."},{"key":"C5BM00534E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.joen.2008.11.001","volume":"35","author":"Zhang","year":"2009","journal-title":"J. Endod."},{"key":"C5BM00534E-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/0022034514561259","volume":"94","author":"Zheng","year":"2015","journal-title":"J. Dent. Res."},{"key":"C5BM00534E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1002623","DOI":"10.1371\/journal.ppat.1002623","volume":"8","author":"Xiao","year":"2012","journal-title":"PLoS Pathog."},{"key":"C5BM00534E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1365-2591.2008.01413.x","volume":"41","author":"Gubler","year":"2008","journal-title":"Int. Endod. J."},{"key":"C5BM00534E-(cit28)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/14767058.2015.1015983","author":"Hansen","year":"2015","journal-title":"J. Matern.-Fetal Neonat. Med."},{"key":"C5BM00534E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e113744","DOI":"10.1371\/journal.pone.0113744","volume":"9","author":"Holcombe","year":"2014","journal-title":"PLoS One"},{"key":"C5BM00534E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1039\/c3tb20445f","volume":"1","author":"Zhou","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"C5BM00534E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/0885328206062360","volume":"21","author":"Wu","year":"2007","journal-title":"J. Biomater. Appl."},{"key":"C5BM00534E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/00220345880670011301","volume":"67","author":"Somerman","year":"1988","journal-title":"J. Dent. Res."},{"key":"C5BM00534E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"C5BM00534E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.joen.2009.09.018","volume":"36","author":"Shen","year":"2010","journal-title":"J. Endod."},{"key":"C5BM00534E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.joen.2009.04.030","volume":"35","author":"Shen","year":"2009","journal-title":"J. Endod."},{"key":"C5BM00534E-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1902\/jop.2013.130161","volume":"85","author":"McKnight","year":"2014","journal-title":"J. Periodontol."},{"key":"C5BM00534E-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1902\/jop.1991.62.8.499","volume":"62","author":"Arceo","year":"1991","journal-title":"J. Periodontol."},{"key":"C5BM00534E-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0757.2005.00141.x","volume":"40","author":"Nanci","year":"2006","journal-title":"Periodontol 2000"},{"key":"C5BM00534E-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1600-0722.2006.00388.x","volume":"114","author":"Gagari","year":"2006","journal-title":"Eur. J. Oral Sci."},{"key":"C5BM00534E-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1021\/am4060035","volume":"6","author":"Wu","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C5BM00534E-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"68","DOI":"10.22203\/eCM.v022a06","volume":"22","author":"Xia","year":"2011","journal-title":"Eur. Cell. Mater."},{"key":"C5BM00534E-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jbm.a.33092","volume":"98","author":"Wu","year":"2011","journal-title":"J. Biomed. Mater. Res. A"},{"key":"C5BM00534E-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1039\/C2BM00108J","volume":"1","author":"Han","year":"2013","journal-title":"Biomater. Sci."},{"key":"C5BM00534E-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bbrc.2007.04.204","volume":"358","author":"Carmona-Rodriguez","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C5BM00534E-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.bone.2005.09.009","volume":"38","author":"Alvarez-Perez","year":"2006","journal-title":"Bone"},{"key":"C5BM00534E-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.actbio.2009.10.007","volume":"6","author":"Robinson","year":"2010","journal-title":"Acta Biomater."},{"key":"C5BM00534E-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1016\/j.biomaterials.2004.09.049","volume":"26","author":"Witte","year":"2005","journal-title":"Biomaterials"},{"key":"C5BM00534E-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.4315\/0362-028X-67.7.1501","volume":"67","author":"Weber","year":"2004","journal-title":"J. Food Prot."},{"key":"C5BM00534E-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.tripleo.2005.03.014","volume":"101","author":"Zehnder","year":"2006","journal-title":"Oral Surg., Oral Med., Oral Pathol., Oral Radiol., Endod."},{"key":"C5BM00534E-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","volume":"15","author":"Donlan","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"C5BM00534E-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm3412","volume":"13","author":"Rizzuto","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C5BM00534E-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1021\/acsami.5b00402","volume":"7","author":"Godoy-Gallardo","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C5BM00534E-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1177\/0022034509346811","volume":"88","author":"Hojo","year":"2009","journal-title":"J. Dent. Res."},{"key":"C5BM00534E-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0132512","DOI":"10.1371\/journal.pone.0132512","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"key":"C5BM00534E-(cit55)\/*[position()=1]","first-page":"2","volume-title":"Textbook of Bacteriology","volume":"2","author":"Todar","year":"2012","unstructured":"K.\n            Todar\n          , Textbook of Bacteriology, 2012, vol. 2, pp. 27"},{"key":"C5BM00534E-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e102108","DOI":"10.1371\/journal.pone.0102108","volume":"9","author":"Ivask","year":"2014","journal-title":"PLoS One"},{"key":"C5BM00534E-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"C5BM00534E-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1021\/bi00010a034","volume":"34","author":"Matsuzaki","year":"1995","journal-title":"Biochemistry"},{"key":"C5BM00534E-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nbt1267","volume":"24","author":"Hancock","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"C5BM00534E-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jcp.1040840211","volume":"84","author":"Froehlich","year":"1974","journal-title":"J. Cell. Physiol."},{"key":"C5BM00534E-(cit61)\/*[position()=1]","first-page":"130","volume":"102","author":"Lengheden","year":"1994","journal-title":"Scand. J. Dent. Res."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/BM\/C5BM00534E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:33:55Z","timestamp":1782880435000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/4\/4\/639-651\/466169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c5bm00534e","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 15 November 2015; Accepted 9 January 2016;  Advance Article published 25 January 2016;  Version of Record published 22 March 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}