{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:53:54Z","timestamp":1790045634228,"version":"4.0.1"},"reference-count":70,"publisher":"Royal Society of Chemistry (RSC)","issue":"65","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<p>The various catalytic asymmetric strategies employing organo- and metal-catalysts utilized pyrazolin-5-one derivatives for the synthesis of potentially bioactive enantiopure pyrazoles and pyrazolones are presented.<\/p>","DOI":"10.1039\/c5cc04930j","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T05:01:51Z","timestamp":1436504511000},"page":"12890-12907","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":288,"title":["Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives"],"prefix":"10.1039","volume":"51","author":[{"given":"Pankaj","family":"Chauhan","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry"},{"name":"RWTH Aachen University"},{"name":"52074 Aachen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suruchi","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry"},{"name":"RWTH Aachen University"},{"name":"52074 Aachen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Enders","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry"},{"name":"RWTH Aachen University"},{"name":"52074 Aachen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C5CC04930J-(cit1a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6984","DOI":"10.1021\/cr2000459","volume":"111","author":"Fustero","year":"2011","journal-title":"Chem. Rev."},{"key":"C5CC04930J-(cit1b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.2174\/138527211795378263","volume":"15","author":"Schmidt","year":"2011","journal-title":"Curr. Org. Chem."},{"key":"C5CC04930J-(cit1c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0065-2725(09)09802-X","volume":"98","author":"Varvounis","year":"2009","journal-title":"Adv. Heterocycl. Chem."},{"key":"C5CC04930J-(cit2)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ejmech.2013.08.053","volume":"69","author":"Kumar","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"C5CC04930J-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1124\/jpet.108.140210","volume":"327","author":"Fujimori","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"C5CC04930J-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.2165\/11208240-000000000-00000","volume":"71","author":"McCormack","year":"2011","journal-title":"Drugs"},{"key":"C5CC04930J-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2885.2010.01165.x","volume":"33","author":"Cox","year":"2010","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"C5CC04930J-(cit6)\/*[position()=1]","unstructured":"European Public Assessment Report (EPAR): Trocoxil. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR-Summary_for_the_public\/veterinary\/000132\/WC500069275.pdf"},{"key":"C5CC04930J-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1016\/j.bmc.2006.03.021","volume":"14","author":"Foloppe","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"C5CC04930J-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1016\/j.bmcl.2012.06.055","volume":"22","author":"Mandha","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C5CC04930J-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1021\/jm00370a020","volume":"27","author":"Kuo","year":"1984","journal-title":"J. Med. Chem."},{"key":"C5CC04930J-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1248\/cpb.40.2547","volume":"40","author":"Huang","year":"1992","journal-title":"Chem. Pharm. Bull."},{"key":"C5CC04930J-(cit13a)\/*[position()=1]","first-page":"143","volume-title":"Pyrazol-3-ones. Part IV: Synthesis and Applications","author":"Varvounis","year":"2009","unstructured":"G.\n              Varvounis\n            , in Pyrazol-3-ones. Part IV: Synthesis and Applications, ed. A. R. Katritzky, Advances in Heterocyclic Chemistry, Academic Press, New York, 2009, vol. 98, p. 143"},{"key":"C5CC04930J-(cit13b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1021\/cr020033s","volume":"103","author":"Horton","year":"2003","journal-title":"Chem. Rev."},{"key":"C5CC04930J-(cit14a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1366-0071(97)80033-2","volume":"1","author":"Brune","year":"1997","journal-title":"Acute Pain"},{"key":"C5CC04930J-(cit14b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1749-6632.1948.tb27246.x","volume":"51","author":"Tainter","year":"1948","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"C5CC04930J-(cit15)\/*[position()=1]","volume-title":"\u201cDipyrone\u201d. Martindale: The Complete Drug Reference","unstructured":"\u201cDipyrone\u201d. Martindale: The Complete Drug Reference, ed. A. Brayfield, Pharmaceutical Press, 2014"},{"key":"C5CC04930J-(cit16a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1248\/yakushi.124.99","volume":"124","author":"Watanabe","year":"2004","journal-title":"Yakugaku Zasshi"},{"key":"C5CC04930J-(cit16b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1527-3458.2006.00009.x","volume":"12","author":"Yoshida","year":"2006","journal-title":"CNS Drug Rev."},{"key":"C5CC04930J-(cit16c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1471-2202-9-75","volume":"9","author":"Ji Yuan","year":"2008","journal-title":"BMC Neurosci."},{"key":"C5CC04930J-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1021\/jm049968m","volume":"47","author":"Clark","year":"2004","journal-title":"J. Med. Chem."},{"key":"C5CC04930J-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1016\/j.bmcl.2010.08.057","volume":"20","author":"Hadi","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C5CC04930J-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jhet.5570440108","volume":"44","author":"Chande","year":"2007","journal-title":"J. Heterocycl. Chem."},{"key":"C5CC04930J-(cit21a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/1099-0690(200206)2002:12<1877::AID-EJOC1877>3.0.CO;2-U","author":"Berner","year":"2002","journal-title":"Eur. J. Org. Chem."},{"key":"C5CC04930J-(cit21b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/j.tetasy.2010.11.001","volume":"21","author":"Roca-Lopez","year":"2010","journal-title":"Tetrahedron: Asymmetry"},{"key":"C5CC04930J-(cit21c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1021\/cr2002195","volume":"113","author":"Ballini","year":"2013","journal-title":"Chem. Rev."},{"key":"C5CC04930J-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/adsc.200900764","volume":"352","author":"Liao","year":"2010","journal-title":"Adv. Synth. Catal."},{"key":"C5CC04930J-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14255","DOI":"10.1002\/chem.201202636","volume":"18","author":"Li","year":"2012","journal-title":"Chem. \u2013 Eur. J."},{"key":"C5CC04930J-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11426-013-5017-3","volume":"57","author":"Zhang","year":"2014","journal-title":"Sci. China: Chem."},{"key":"C5CC04930J-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1002\/ejoc.201300460","author":"Wang","year":"2013","journal-title":"Eur. J. Org. Chem."},{"key":"C5CC04930J-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6215","DOI":"10.1039\/c3ob41045e","volume":"11","author":"Li","year":"2013","journal-title":"Org. Biomol. Chem."},{"key":"C5CC04930J-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1039\/C4OB02653E","volume":"13","author":"Li","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"C5CC04930J-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1039\/C4CC09495F","volume":"51","author":"Hack","year":"2015","journal-title":"Chem. Commun."},{"key":"C5CC04930J-(cit29a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6953","DOI":"10.1039\/c0cc01522a","volume":"46","author":"Company\u00f3","year":"2010","journal-title":"Chem. Commun."},{"key":"C5CC04930J-(cit29b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/ejoc.201001452","author":"Alba","year":"2011","journal-title":"Eur. J. Org. Chem."},{"key":"C5CC04930J-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1021\/ol301983f","volume":"14","author":"Enders","year":"2012","journal-title":"Org. Lett."},{"key":"C5CC04930J-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1002\/ejoc.201403673","author":"Zhang","year":"2015","journal-title":"Eur. J. Org. Chem."},{"key":"C5CC04930J-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1021\/acs.orglett.5b00293","volume":"17","author":"Yetra","year":"2015","journal-title":"Org. Lett."},{"key":"C5CC04930J-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/ejoc.201101529","author":"Wu","year":"2012","journal-title":"Eur. J. Org. Chem."},{"key":"C5CC04930J-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1002\/anie.201008256","volume":"50","author":"Wang","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5CC04930J-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1002\/anie.201109130","volume":"51","author":"Wang","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5CC04930J-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14538","DOI":"10.1039\/c3ra45974h","volume":"4","author":"Li","year":"2014","journal-title":"RSC Adv."},{"key":"C5CC04930J-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1039\/c2ob06553c","volume":"10","author":"Mazzanti","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"C5CC04930J-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.tetlet.2009.02.210","volume":"50","author":"Gogoi","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"C5CC04930J-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/cjoc.201400829","volume":"33","author":"Li","year":"2015","journal-title":"Chin. J. Chem."},{"key":"C5CC04930J-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"825","DOI":"10.6023\/A14040319","volume":"72","author":"Ma","year":"2014","journal-title":"Acta Chim. Sin."},{"key":"C5CC04930J-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9255","DOI":"10.1021\/ja402740q","volume":"135","author":"Tao","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"C5CC04930J-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1021\/ol102804p","volume":"13","author":"Yang","year":"2011","journal-title":"Org. Lett."},{"key":"C5CC04930J-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/ajoc.201200168","volume":"2","author":"\u0160imek","year":"2013","journal-title":"Asian J. Org. Chem."},{"key":"C5CC04930J-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1002\/anie.201311214","volume":"53","author":"Han","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5CC04930J-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1021\/ol900538q","volume":"11","author":"Gogoi","year":"2009","journal-title":"Org. Lett."},{"key":"C5CC04930J-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1002\/adsc.201300964","volume":"356","author":"Rassu","year":"2014","journal-title":"Adv. Synth. Catal."},{"key":"C5CC04930J-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.1039\/c1ob05753g","volume":"9","author":"Zea","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"C5CC04930J-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8574","DOI":"10.3390\/molecules20058574","volume":"20","author":"Ceban","year":"2015","journal-title":"Molecules"},{"key":"C5CC04930J-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1039\/C2OB27095A","volume":"11","author":"Liang","year":"2013","journal-title":"Org. Biomol. Chem."},{"key":"C5CC04930J-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/adsc.201200925","volume":"355","author":"Zhang","year":"2013","journal-title":"Adv. Synth. Catal."},{"key":"C5CC04930J-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1021\/ol501093v","volume":"16","author":"Chauhan","year":"2014","journal-title":"Org. Lett."},{"key":"C5CC04930J-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/adsc.201400764","volume":"357","author":"Han","year":"2015","journal-title":"Adv. Synth. Catal."},{"key":"C5CC04930J-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9330","DOI":"10.1016\/j.tet.2014.10.038","volume":"70","author":"Sun","year":"2014","journal-title":"Tetrahedron"},{"key":"C5CC04930J-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10228","DOI":"10.1021\/jo301851a","volume":"77","author":"Liu","year":"2012","journal-title":"J. Org. Chem."},{"key":"C5CC04930J-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1039\/c3cc38386e","volume":"49","author":"Chen","year":"2013","journal-title":"Chem. Commun."},{"key":"C5CC04930J-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.tet.2014.01.036","volume":"70","author":"Cui","year":"2014","journal-title":"Tetrahedron"},{"key":"C5CC04930J-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1002\/asia.201402706","volume":"9","author":"Li","year":"2014","journal-title":"Chem. \u2013 Asian J."},{"key":"C5CC04930J-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"42836","DOI":"10.1039\/C5RA04356E","volume":"5","author":"Wang","year":"2015","journal-title":"RSC Adv."},{"key":"C5CC04930J-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cclet.2014.01.034","volume":"25","author":"Zhang","year":"2014","journal-title":"Chin. Chem. Lett."},{"key":"C5CC04930J-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1039\/c3ob41455h","volume":"11","author":"Zhang","year":"2013","journal-title":"Org. Biomol. Chem."},{"key":"C5CC04930J-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11329","DOI":"10.1002\/anie.201302622","volume":"52","author":"Jiang","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5CC04930J-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1002\/ejoc.201300524","author":"Geng","year":"2013","journal-title":"Eur. J. Org. Chem."},{"key":"C5CC04930J-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.tet.2013.11.038","volume":"70","author":"Geng","year":"2014","journal-title":"Tetrahedron"},{"key":"C5CC04930J-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1039\/C5SC00835B","volume":"6","author":"Chen","year":"2015","journal-title":"Chem. Sci."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/CC\/C5CC04930J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:17:08Z","timestamp":1782850628000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/51\/65\/12890-12907\/468049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":70,"journal-issue":{"issue":"65","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c5cc04930j","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 15 June 2015; Accepted 10 July 2015;  Accepted Manuscript published 10 July 2015;  Advance Article published 16 July 2015;  Version of Record published 30 July 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}