{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:24:56Z","timestamp":1782887096188,"version":"3.54.5"},"reference-count":31,"publisher":"Royal Society of Chemistry (RSC)","issue":"11","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>Limonin has been found to possess significant anti-inflammatory properties, however, its precise metabolism mechanism has not been well explored.<\/p>","DOI":"10.1039\/c5fo00489f","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:01:17Z","timestamp":1438941677000},"page":"3540-3549","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Metabolomics strategy reveals therapeutical assessment of limonin on nonbacterial prostatitis"],"prefix":"10.1039","volume":"6","author":[{"given":"Aihua","family":"Zhang","sequence":"first","affiliation":[{"name":"National TCM Key Laboratory of Serum Pharmacochemistry"},{"name":"Laboratory of Metabolomics and Chinmedomics"},{"name":"Department of Pharmaceutical Analysis"},{"name":"Heilongjiang University of Chinese Medicine"},{"name":"Harbin 150040"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"National TCM Key Laboratory of Serum Pharmacochemistry"},{"name":"Laboratory of Metabolomics and Chinmedomics"},{"name":"Department of Pharmaceutical Analysis"},{"name":"Heilongjiang University of Chinese Medicine"},{"name":"Harbin 150040"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"National TCM Key Laboratory of Serum Pharmacochemistry"},{"name":"Laboratory of Metabolomics and Chinmedomics"},{"name":"Department of Pharmaceutical Analysis"},{"name":"Heilongjiang University of Chinese Medicine"},{"name":"Harbin 150040"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"National TCM Key Laboratory of Serum Pharmacochemistry"},{"name":"Laboratory of Metabolomics and Chinmedomics"},{"name":"Department of Pharmaceutical Analysis"},{"name":"Heilongjiang University of Chinese Medicine"},{"name":"Harbin 150040"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"An","sequence":"additional","affiliation":[{"name":"National TCM Key Laboratory of Serum Pharmacochemistry"},{"name":"Laboratory of Metabolomics and Chinmedomics"},{"name":"Department of Pharmaceutical Analysis"},{"name":"Heilongjiang University of Chinese Medicine"},{"name":"Harbin 150040"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangli","family":"Yan","sequence":"additional","affiliation":[{"name":"National TCM Key Laboratory of Serum Pharmacochemistry"},{"name":"Laboratory of Metabolomics and Chinmedomics"},{"name":"Department of Pharmaceutical Analysis"},{"name":"Heilongjiang University of Chinese Medicine"},{"name":"Harbin 150040"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangcai","family":"Meng","sequence":"additional","affiliation":[{"name":"National TCM Key Laboratory of Serum Pharmacochemistry"},{"name":"Laboratory of Metabolomics and Chinmedomics"},{"name":"Department of Pharmaceutical Analysis"},{"name":"Heilongjiang University of Chinese Medicine"},{"name":"Harbin 150040"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijun","family":"Wang","sequence":"additional","affiliation":[{"name":"National TCM Key Laboratory of Serum Pharmacochemistry"},{"name":"Laboratory of Metabolomics and Chinmedomics"},{"name":"Department of Pharmaceutical Analysis"},{"name":"Heilongjiang University of Chinese Medicine"},{"name":"Harbin 150040"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C5FO00489F-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e96824","DOI":"10.1371\/journal.pone.0096824","volume":"9","author":"Zeng","year":"2013","journal-title":"PLoS One"},{"key":"C5FO00489F-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.juro.2007.07.120","volume":"180","author":"Chuang","year":"2008","journal-title":"J. Urol."},{"key":"C5FO00489F-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.eururo.2006.11.037","volume":"51","author":"Chuang","year":"2007","journal-title":"Eur. Urol."},{"key":"C5FO00489F-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1039\/C4FO00052H","volume":"5","author":"Hu","year":"2014","journal-title":"Food Funct."},{"key":"C5FO00489F-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1248\/bpb.29.191","volume":"29","author":"Roy","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"C5FO00489F-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/cbdv.201300406","volume":"11","author":"Manosroi","year":"2014","journal-title":"Chem. Biodiversity"},{"key":"C5FO00489F-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10408398.2011.581400","volume":"54","author":"Tundis","year":"2014","journal-title":"CRC Crit. Rev. Food Sci. Nutr."},{"key":"C5FO00489F-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1248\/bpb.29.191","volume":"29","author":"Roy","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"C5FO00489F-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1039\/C2FO30209H","volume":"4","author":"Kim","year":"2013","journal-title":"Food Funct."},{"key":"C5FO00489F-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejphar.2011.08.035","volume":"670","author":"Kim","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"C5FO00489F-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4103\/0976-9668.107276","volume":"4","author":"Langeswaran","year":"2013","journal-title":"J. Nat. Sci., Biol. Med."},{"key":"C5FO00489F-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/biof.5520130133","volume":"13","author":"Tanaka","year":"2000","journal-title":"Biofactors"},{"key":"C5FO00489F-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3945\/jn.108.102772","volume":"139","author":"Kim","year":"2009","journal-title":"J. Nutr."},{"key":"C5FO00489F-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bcp.2010.03.028","volume":"80","author":"Gong","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"C5FO00489F-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1021\/jf060901c","volume":"54","author":"Breksa","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"C5FO00489F-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1055\/s-2003-45099","volume":"69","author":"Battinelli","year":"2003","journal-title":"Planta Med."},{"key":"C5FO00489F-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e71403","DOI":"10.1371\/journal.pone.0071403","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"C5FO00489F-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/ncomms1562","volume":"2","author":"Tiziani","year":"2011","journal-title":"Nat. Commun."},{"key":"C5FO00489F-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1074\/mcp.M112.021683","volume":"12","author":"Wang","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"C5FO00489F-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1038\/srep06768","volume":"4","author":"Zhang","year":"2014","journal-title":"Sci. Rep."},{"key":"C5FO00489F-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1073\/pnas.1218524110","volume":"110","author":"Derewacz","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5FO00489F-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1038\/ncomms4056","volume":"5","author":"Rao","year":"2014","journal-title":"Nat. Commun."},{"key":"C5FO00489F-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nature10354","volume":"477","author":"Suhre","year":"2011","journal-title":"Nature"},{"key":"C5FO00489F-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nature07762","volume":"457","author":"Sreekumar","year":"2009","journal-title":"Nature"},{"key":"C5FO00489F-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1039\/C4MB00222A","volume":"10","author":"Zhang","year":"2014","journal-title":"Mol. BioSyst."},{"key":"C5FO00489F-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1507, e15","DOI":"10.1016\/j.urology.2011.02.017","volume":"77","author":"Tsunemori","year":"2011","journal-title":"Urology"},{"issue":"3","key":"C5FO00489F-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1089\/omi.2014.0112","volume":"19","author":"Sun","year":"2015","journal-title":"OMICS"},{"key":"C5FO00489F-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1038\/ncomms5708","volume":"5","author":"Auro","year":"2014","journal-title":"Nat. Commun."},{"key":"C5FO00489F-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1074\/mcp.M112.021816","volume":"12","author":"Zheng","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"C5FO00489F-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/ncomms2418","volume":"4","author":"Martin","year":"2013","journal-title":"Nat. Commun."},{"key":"C5FO00489F-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/456443c","volume":"456","author":"Arakaki","year":"2008","journal-title":"Nature"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/FO\/C5FO00489F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:02:54Z","timestamp":1782882174000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/6\/11\/3540-3549\/479791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c5fo00489f","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C5FO00489F","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 3 May 2015; Accepted 5 August 2015;  Accepted Manuscript published 7 August 2015;  Advance Article published 24 August 2015;  Version of Record published 4 November 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}