{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:52:48Z","timestamp":1790747568402,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000147","name":"Division of Civil, Mechanical and Manufacturing Innovation","doi-asserted-by":"publisher","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/100000147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000147","name":"Division of Civil, Mechanical and Manufacturing Innovation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000147","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,5,11]]},"DOI":"10.1039\/c5ib00073d","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T11:01:15Z","timestamp":1429527675000},"page":"580-590","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Inhibition of cell\u2013cell adhesion impairs directional epithelial migration on micropatterned surfaces"],"prefix":"10.1093","volume":"7","author":[{"given":"Kathryn E.","family":"Worley","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Laboratory for Tissue Engineering and Morphogenesis, 2147 Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA. Web: http:\/\/www.rpi.edu\/\u223cwanq; Fax: +1-518-276-3035; Tel: +1-518-276-2505"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shieh","sequence":"additional","affiliation":[{"name":"Department of Biology, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo Q.","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Laboratory for Tissue Engineering and Morphogenesis, 2147 Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA. Web: http:\/\/www.rpi.edu\/\u223cwanq; Fax: +1-518-276-3035; Tel: +1-518-276-2505"},{"name":"Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA"},{"name":"Center for Modeling, Simulation and Imaging in Medicine, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,4,29]]},"reference":[{"key":"key\n\t\t\t\t2019012511002813600_cit1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2006.09.018","article-title":"The key to left-right asymmetry","volume":"127","author":"Tabin","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019012511002813600_cit2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/bies.950190406","article-title":"Left-right asymmetry in vertebrate embryogenesis","volume":"19","author":"Levin","year":"1997","journal-title":"BioEssays"},{"key":"key\n\t\t\t\t2019012511002813600_cit3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.109.1.1","article-title":"The development of handedness in left\/right asymmetry","volume":"109","author":"Brown","year":"1990","journal-title":"Development"},{"key":"key\n\t\t\t\t2019012511002813600_cit4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.gde.2007.05.008","article-title":"Strategies to establish left\/right asymmetry in vertebrates and invertebrates","volume":"17","author":"Speder","year":"2007","journal-title":"Curr. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t2019012511002813600_cit5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/ajmg.1219","article-title":"Clinical aspects of defects in the determination of laterality","volume":"101","author":"Aylsworth","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"key\n\t\t\t\t2019012511002813600_cit6","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1038\/ncomms3754","article-title":"A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality","volume":"4","author":"Noel","year":"2013","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t2019012511002813600_cit7","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.mod.2014.04.002","article-title":"Left-right asymmetry is formed in individual cells by intrinsic cell chirality","volume":"133","author":"Hatori","year":"2014","journal-title":"Mech. Dev."},{"key":"key\n\t\t\t\t2019012511002813600_cit8","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1126\/science.288.5468.1047","article-title":"QJ;N-Cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry","volume":"288","author":"Garcia-Castro","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t2019012511002813600_cit9","doi-asserted-by":"crossref","first-page":"12295","DOI":"10.1073\/pnas.1103834108","article-title":"From the cover: micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry","volume":"108","author":"Wan","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t2019012511002813600_cit10","doi-asserted-by":"crossref","first-page":"745","DOI":"10.4161\/cib.17649","article-title":"Micropatterning chiral morphogenesis","volume":"4","author":"Wan","year":"2011","journal-title":"Commun. Integr. Biol."},{"key":"key\n\t\t\t\t2019012511002813600_cit11","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1021\/nn405253d","article-title":"Carbon nanotube-induced loss of multicellular chirality on micropatterned substrate is mediated by oxidative stress","volume":"8","author":"Singh","year":"2014","journal-title":"ACS Nano"},{"key":"key\n\t\t\t\t2019012511002813600_cit12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/scrt172","article-title":"Micropatterning of cells reveals chiral morphogenesis","volume":"4","author":"Wan","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"key\n\t\t\t\t2019012511002813600_cit13","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1038\/ncomms4747","article-title":"Emergence of collective modes and tri-dimensional structures from epithelial confinement","volume":"5","author":"Deforet","year":"2014","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t2019012511002813600_cit14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/CIRCRESAHA.111.255927","article-title":"Left-Right Symmetry Breaking in Tissue Morphogenesis via Cytoskeletal Mechanics","volume":"110","author":"Chen","year":"2012","journal-title":"Circ. Res."},{"key":"key\n\t\t\t\t2019012511002813600_cit15","doi-asserted-by":"crossref","first-page":"9296","DOI":"10.1073\/pnas.0703153104","article-title":"Polarity reveals intrinsic cell chirality","volume":"104","author":"Xu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t2019012511002813600_cit16","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1114\/1.226","article-title":"Measurement of orientation and distribution of cellular alignment and cytoskeletal organization","volume":"27","author":"Karlon","year":"1999","journal-title":"Ann. Biomed. Eng."},{"key":"key\n\t\t\t\t2019012511002813600_cit17","volume-title":"R: A language and environment for statistical computing, R Foundation for Statistical Computing","year":"2013"},{"key":"key\n\t\t\t\t2019012511002813600_cit18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00232-001-0182-2","article-title":"Dynamics of tight and adherens junctions under EGTA treatment","volume":"188","author":"Rothen-Rutishauser","year":"2002","journal-title":"J. Membr. Biol."},{"key":"key\n\t\t\t\t2019012511002813600_cit19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2490-9-19","article-title":"Normal kidney size and its influencing factors - a 64-slice MDCT study of 1.040 asymptomatic patients","volume":"9","author":"Glodny","year":"2009","journal-title":"BMC Urol."},{"key":"key\n\t\t\t\t2019012511002813600_cit20","first-page":"123","article-title":"Normal variance in renal size in relation to body habitus","volume":"15","author":"Harmse","year":"2011","journal-title":"J. Radiol."},{"key":"key\n\t\t\t\t2019012511002813600_cit21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/01.HYP.0000050928.96979.A5","article-title":"Asymmetry of renal blood flow in patients with moderate to severe hypertension","volume":"41","author":"van Onna","year":"2003","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t2019012511002813600_cit22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1681\/ASN.2012050490","article-title":"Loss of the ciliary kinase Nek8 causes left-right asymmetry defects","volume":"24","author":"Manning","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"key\n\t\t\t\t2019012511002813600_cit23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/26006","article-title":"Cloning of inv, a gene that controls left\/right asymmetry and kidney development","volume":"395","author":"Mochizuki","year":"1998","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019012511002813600_cit24","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1242\/dev.127.11.2347","article-title":"The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination","volume":"127","author":"Murcia","year":"2000","journal-title":"Development"},{"key":"key\n\t\t\t\t2019012511002813600_cit25","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1242\/jcs.028183","article-title":"Cell polarity triggered by cell\u2013cell adhesion via E-cadherin","volume":"122","author":"Desai","year":"2009","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t2019012511002813600_cit26","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.bpj.2010.01.030","article-title":"Velocity Fields in a Collectively Migrating Epithelium","volume":"98","author":"Petitjean","year":"2010","journal-title":"Biophys. J."},{"key":"key\n\t\t\t\t2019012511002813600_cit27","doi-asserted-by":"crossref","first-page":"12974","DOI":"10.1073\/pnas.1119313109","article-title":"Emerging modes of collective cell migration induced by geometrical constraints","volume":"109","author":"Vedula","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t2019012511002813600_cit28","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.bpj.2014.07.017","article-title":"Flow and diffusion in channel-guided cell migration","volume":"107","author":"Marel","year":"2014","journal-title":"Biophys. J."},{"key":"key\n\t\t\t\t2019012511002813600_cit29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0092-8674(00)81559-7","article-title":"Directed actin polymerization is the driving force for epithelial cell\u2013cell adhesion","volume":"100","author":"Vasioukhin","year":"2000","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019012511002813600_cit30","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.cell.2005.09.020","article-title":"Deconstructing the cadherin-catenin-actin complex","volume":"123","author":"Yamada","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019012511002813600_cit31","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1007\/s00018-012-0951-3","article-title":"E-cadherin plays an essential role in collective directional migration of large epithelial sheets","volume":"69","author":"Li","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"key\n\t\t\t\t2019012511002813600_cit32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ceb.2010.07.010","article-title":"Conserved F-actin dynamics and force transmission at cell adhesions","volume":"22","author":"Maruthamuthu","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"key\n\t\t\t\t2019012511002813600_cit33","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1073\/pnas.1010059108","article-title":"Glass-like dynamics of collective cell migration","volume":"108","author":"Angelini","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t2019012511002813600_cit34","doi-asserted-by":"crossref","first-page":"168104","DOI":"10.1103\/PhysRevLett.104.168104","article-title":"Cell migration driven by cooperative substrate deformation patterns","volume":"104","author":"Angelini","year":"2010","journal-title":"Phys. Rev. Lett."},{"key":"key\n\t\t\t\t2019012511002813600_cit35","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1038\/ncomms4747","article-title":"Emergence of collective modes and tri-dimensional structures from epithelial confinement","volume":"5","author":"Deforet","year":"2014","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t2019012511002813600_cit36","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1039\/c3ib40054a","article-title":"Guidance of collective cell migration by substrate geometry","volume":"5","author":"Doxzen","year":"2013","journal-title":"Integr. Biol."},{"key":"key\n\t\t\t\t2019012511002813600_cit37","doi-asserted-by":"crossref","first-page":"15988","DOI":"10.1073\/pnas.0705062104","article-title":"Collective migration of an epithelial monolayer in response to a model wound","volume":"104","author":"Poujade","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t2019012511002813600_cit38","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nature10999","article-title":"Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia","volume":"484","author":"Eisenhoffer","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019012511002813600_cit39","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.1172478","article-title":"Cell Movements at Hensen's Node Establish Left\/Right Asymmetric Gene Expression in the Chick","volume":"324","author":"Gros","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t2019012511002813600_cit40","doi-asserted-by":"crossref","first-page":"e1003109","DOI":"10.1371\/journal.pgen.1003109","article-title":"Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry","volume":"9","author":"Lenhart","year":"2013","journal-title":"PLoS Genet."}],"container-title":["Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ib\/article-pdf\/7\/5\/580\/27282729\/c5ib00073d.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T14:44:40Z","timestamp":1651761880000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ib\/article\/7\/5\/580\/5193021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,29]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,4,29]]},"published-print":{"date-parts":[[2015,5,11]]}},"URL":"https:\/\/doi.org\/10.1039\/c5ib00073d","relation":{},"ISSN":["1757-9708"],"issn-type":[{"value":"1757-9708","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,5]]},"published":{"date-parts":[[2015,4,29]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C5IB00073D","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 12 March 2015; Accepted 20 April 2015; Accepted Manuscript published 20 April 2015; Advance Article published 29 April 2015; Version of Record published 11 May 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}