{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:10:42Z","timestamp":1783577442948,"version":"3.55.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"11","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["R21CA138366"],"award-info":[{"award-number":["R21CA138366"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Integr. Biol."],"abstract":"<p>A novel microfluidic model reveals roles of interstitial flows in regulating tumor cell morphology and migration within a 3D collagen matrix. This work highlights the importance of biological flows in tumor cell dissemination.<\/p>","DOI":"10.1039\/c5ib00115c","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T04:32:42Z","timestamp":1437366762000},"page":"1402-1411","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Interstitial flows promote amoeboid over mesenchymal motility of breast cancer cells revealed by a three dimensional microfluidic model"],"prefix":"10.1093","volume":"7","author":[{"given":"Yu Ling","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Biological and Environmental Engineering"},{"name":"Cornell University"},{"name":"Ithaca"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-kuan","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Engineering"},{"name":"Cornell University"},{"name":"Ithaca"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Engineering"},{"name":"Cornell University"},{"name":"Ithaca"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beum Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Engineering"},{"name":"Cornell University"},{"name":"Ithaca"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Engineering"},{"name":"Cornell University"},{"name":"Ithaca"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C5IB00115C-(cit1)\/*[position()=1]","first-page":"3039","volume":"47","author":"Jain","year":"1987","journal-title":"Cancer Res."},{"key":"C5IB00115C-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1073\/pnas.86.14.5385","volume":"86","author":"Chary","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5IB00115C-(cit3)\/*[position()=1]","first-page":"3084","volume":"35","author":"Butler","year":"1975","journal-title":"Cancer Res."},{"key":"C5IB00115C-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1158\/0008-5472.CAN-12-0903","volume":"72","author":"Hompland","year":"2012","journal-title":"Cancer Res."},{"key":"C5IB00115C-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2147\/CMAR.S65444","volume":"6","author":"Munson","year":"2014","journal-title":"Cancer Manage. Res."},{"key":"C5IB00115C-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrc1456","volume":"4","author":"Heldin","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"C5IB00115C-(cit7)\/*[position()=1]","first-page":"6371","volume":"52","author":"Less","year":"1992","journal-title":"Cancer Res."},{"key":"C5IB00115C-(cit8)\/*[position()=1]","first-page":"4264","volume":"56","author":"Boucher","year":"1996","journal-title":"Cancer Res."},{"key":"C5IB00115C-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199101033240101","volume":"324","author":"Weidner","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"C5IB00115C-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/jemt.1160","volume":"55","author":"Swartz","year":"2001","journal-title":"Microsc. Res. Tech."},{"key":"C5IB00115C-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/84643","volume":"7","author":"Skobe","year":"2001","journal-title":"Nat. Med."},{"key":"C5IB00115C-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2353\/ajpath.2007.060761","volume":"170","author":"Harrell","year":"2007","journal-title":"Am. J. Pathol."},{"key":"C5IB00115C-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrc2544","volume":"9","author":"Butcher","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"C5IB00115C-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/cvr\/cvq143","volume":"87","author":"Reed","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"C5IB00115C-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO;2-H","volume":"63","author":"Carter","year":"1989","journal-title":"Cancer"},{"key":"C5IB00115C-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jss.2009.05.004","volume":"167","author":"Cai","year":"2011","journal-title":"J. Surg. Res."},{"key":"C5IB00115C-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ccr.2007.04.020","volume":"11","author":"Shields","year":"2007","journal-title":"Cancer Cell"},{"key":"C5IB00115C-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1158\/0008-5472.CAN-12-2838","volume":"73","author":"Munson","year":"2013","journal-title":"Cancer Res."},{"key":"C5IB00115C-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"C5IB00115C-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1083\/jcb.200909003","volume":"188","author":"Friedl","year":"2010","journal-title":"J. Cell Biol."},{"key":"C5IB00115C-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nrc1231","volume":"3","author":"Condeelis","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"C5IB00115C-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2818.2008.02056.x","volume":"231","author":"Pinner","year":"2008","journal-title":"J. Microsc."},{"key":"C5IB00115C-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature06887","volume":"453","author":"Lammermann","year":"2008","journal-title":"Nature"},{"key":"C5IB00115C-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1039\/c0ib00050g","volume":"2","author":"Guck","year":"2010","journal-title":"Integr. Biol."},{"key":"C5IB00115C-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1016\/j.bpj.2011.09.022","volume":"101","author":"Ricart","year":"2011","journal-title":"Biophys. J."},{"key":"C5IB00115C-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/embor.2010.147","volume":"11","author":"Renkawitz","year":"2010","journal-title":"EMBO Rep."},{"key":"C5IB00115C-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1440-1827.2002.01343.x","volume":"52","author":"Nabeshima","year":"2002","journal-title":"Pathol. Int."},{"key":"C5IB00115C-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10889","DOI":"10.1073\/pnas.0604460103","volume":"103","author":"Zaman","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5IB00115C-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nrc1075","volume":"3","author":"Friedl","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"C5IB00115C-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/(SICI)1097-0029(19981201)43:5<369::AID-JEMT3>3.0.CO;2-6","volume":"43","author":"Friedl","year":"1998","journal-title":"Microsc. Res. Tech."},{"key":"C5IB00115C-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1126\/science.1064829","volume":"294","author":"Cukierman","year":"2001","journal-title":"Science"},{"key":"C5IB00115C-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1083\/jcb.200209006","volume":"160","author":"Wolf","year":"2003","journal-title":"J. Cell Biol."},{"key":"C5IB00115C-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tips.2013.03.001","volume":"34","author":"Wells","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"C5IB00115C-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1158\/0008-5472.CAN-10-1513","volume":"71","author":"Shieh","year":"2011","journal-title":"Cancer Res."},{"key":"C5IB00115C-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11115","DOI":"10.1073\/pnas.1103581108","volume":"108","author":"Polacheck","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5IB00115C-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1039\/C1IB00128K","volume":"4","author":"Haessler","year":"2012","journal-title":"Integr. Biol."},{"key":"C5IB00115C-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1039\/c3lc50489a","volume":"13","author":"Tung","year":"2013","journal-title":"Lab Chip"},{"key":"C5IB00115C-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"021011","DOI":"10.1115\/1.4026447","volume":"136","author":"Wu","year":"2014","journal-title":"J. Biomech. Eng."},{"key":"C5IB00115C-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1073\/pnas.1316848111","volume":"111","author":"Polacheck","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5IB00115C-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e68422","DOI":"10.1371\/journal.pone.0068422","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"key":"C5IB00115C-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1039\/c0lc00643b","volume":"11","author":"Vulto","year":"2011","journal-title":"Lab Chip"},{"key":"C5IB00115C-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1016\/j.biomaterials.2010.07.072","volume":"31","author":"Cross","year":"2010","journal-title":"Biomaterials"},{"key":"C5IB00115C-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1083\/jcb.201201124","volume":"197","author":"Petrie","year":"2012","journal-title":"J. Cell Biol."},{"key":"C5IB00115C-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bpj.2009.03.064","volume":"97","author":"Chauhan","year":"2009","journal-title":"Biophys. J."},{"key":"C5IB00115C-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.cell.2008.09.043","volume":"135","author":"Sanz-Moreno","year":"2008","journal-title":"Cell"},{"key":"C5IB00115C-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.biomaterials.2009.10.047","volume":"31","author":"Ulrich","year":"2010","journal-title":"Biomaterials"},{"key":"C5IB00115C-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/onc.2009.2","volume":"28","author":"Yamazaki","year":"2009","journal-title":"Oncogene"},{"key":"C5IB00115C-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/ncb1019","volume":"5","author":"Sahai","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"C5IB00115C-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrm2957","volume":"11","author":"Parsons","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C5IB00115C-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1242\/jcs.00059","volume":"115","author":"Pankov","year":"2002","journal-title":"J. Cell Sci."},{"key":"C5IB00115C-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1073\/pnas.1318967111","volume":"111","author":"Wu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5IB00115C-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1039\/c0ib00095g","volume":"3","author":"Pathak","year":"2011","journal-title":"Integr. Biol."},{"key":"C5IB00115C-(cit53)\/*[position()=1]","volume-title":"Random walks in biology","author":"Berg","year":"1983","unstructured":"H. C.\n            Berg\n          , Random walks in biology, Princeton University Press, Princeton, N.J., 1983"},{"key":"C5IB00115C-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1529\/biophysj.107.120006","volume":"94","author":"Raub","year":"2008","journal-title":"Biophys. J."},{"key":"C5IB00115C-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1115\/1.1449904","volume":"124","author":"Roeder","year":"2002","journal-title":"J. Biomech. Eng."},{"key":"C5IB00115C-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.yexcr.2013.06.009","volume":"319","author":"Hall","year":"2013","journal-title":"Exp. Cell Res."},{"key":"C5IB00115C-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1741-7015-4-38","volume":"4","author":"Provenzano","year":"2006","journal-title":"BMC Med."},{"key":"C5IB00115C-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1158\/1055-9965.EPI-04-0490","volume":"14","author":"Li","year":"2005","journal-title":"Cancer Epidemiol., Biomarkers Prev."},{"key":"C5IB00115C-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1158\/0008-5472.CAN-08-4859","volume":"69","author":"Ulrich","year":"2009","journal-title":"Cancer Res."},{"key":"C5IB00115C-(cit60)\/*[position()=1]","volume-title":"Rho GTPases","author":"Spiering","year":"2012","unstructured":"D.\n            Spiering\n           and L.Hodgson, in Rho GTPases, ed. F. Rivero, Springer New York, 2012, ch. 15, vol. 827, pp. 215\u2013234"},{"key":"C5IB00115C-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature08242","volume":"461","author":"Machacek","year":"2009","journal-title":"Nature"}],"container-title":["Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/IB\/C5IB00115C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T15:31:29Z","timestamp":1547825489000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ib\/article\/7\/11\/1402-1411\/5198253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c5ib00115c","relation":{},"ISSN":["1757-9694","1757-9708"],"issn-type":[{"value":"1757-9694","type":"print"},{"value":"1757-9708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C5IB00115C","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Beum Jun Kim (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/G-6829-2011","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 4 May 2015; Accepted 17 July 2015;  Accepted Manuscript published 20 July 2015;  Advance Article published 3 August 2015;  Version of Record published 2 November 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}