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Molecular mechanisms of cryptococcal infection in brain have been studied using experimental animal models and cell lines. There are limited studies for the molecular understanding of cryptococcal meningitis in human brain. The proteins involved in the process of invasion and infection in human brain still remains obscure. To this end we carried out mass spectrometry-based quantitative proteomics of frontal lobe brain tissues from cryptococcal meningitis patients and controls to identify host proteins that are associated with the pathogenesis of cryptococcal meningitis. We identified 317 proteins to be differentially expressed (\u22652-fold) from a total of 3423 human proteins. We found proteins involved in immune response and signal transduction to be differentially expressed in response to cryptococcal infection in human brain. Immune response proteins including complement factors, major histocompatibility proteins, proteins previously known to be involved in fungal invasion to brain such as caveolin 1 and actin were identified to be differentially expressed in cryptococcal meningitis brain tissues co-infected with HIV. We also validated the expression status of 5 proteins using immunohistochemistry. Overexpression of major histocompatibility complexes, class I, B (HLA-B), actin alpha 2 smooth muscle aorta (ACTA2) and caveolin 1 (CAV1) and downregulation of peripheral myelin protein 2 (PMP2) and alpha crystallin B chain (CRYAB) in cryptococcal meningitis were confirmed by IHC-based validation experiments. This study provides the brain proteome profile of cryptococcal meningitis co-infected with HIV for a better understanding of the host response associated with the disease.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c5mb00187k","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T12:02:07Z","timestamp":1435579327000},"page":"2529-2540","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Characterization of host response to\n                    <i>Cryptococcus neoformans<\/i>\n                    through quantitative proteomic analysis of cryptococcal meningitis co-infected with HIV"],"prefix":"10.1093","volume":"11","author":[{"given":"Lakshmi Dhevi N","family":"Selvan","sequence":"first","affiliation":[{"name":"Amrita School of Biotechnology, Amrita University b , Kollam 690525, India"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560066, India \u00a0 keshav@ibioinformatics.org \u00a0 +91-80-28416132 \u00a0 +91-80-28416140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreelakshmi K","family":"Sreenivasamurthy","sequence":"additional","affiliation":[{"name":"Manipal University, Madhav Nagar c , Manipal, Karnataka 576104, India"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560066, India \u00a0 keshav@ibioinformatics.org \u00a0 +91-80-28416132 \u00a0 +91-80-28416140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satwant","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560066, India \u00a0 keshav@ibioinformatics.org \u00a0 +91-80-28416132 \u00a0 +91-80-28416140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soujanya D","family":"Yelamanchi","sequence":"additional","affiliation":[{"name":"School of Biotechnology, KIIT University d , Bhubaneswar, Odisha 751024, India"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560066, India \u00a0 keshav@ibioinformatics.org \u00a0 +91-80-28416132 \u00a0 +91-80-28416140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K","family":"Madugundu","sequence":"additional","affiliation":[{"name":"Bioinformatics Centre, School of Life Sciences, Pondicherry University e , Puducherry 605014, India"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560066, India \u00a0 keshav@ibioinformatics.org \u00a0 +91-80-28416132 \u00a0 +91-80-28416140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijith K","family":"Anil","sequence":"additional","affiliation":[{"name":"Armed Forces Medical College f , Pune 411040, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Renuse","sequence":"additional","affiliation":[{"name":"Amrita School of Biotechnology, Amrita University b , Kollam 690525, India"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560066, India \u00a0 keshav@ibioinformatics.org \u00a0 +91-80-28416132 \u00a0 +91-80-28416140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipin G","family":"Nair","sequence":"additional","affiliation":[{"name":"Amrita School of Biotechnology, Amrita University b , Kollam 690525, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha","family":"Gowda","sequence":"additional","affiliation":[{"name":"YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University g , Mangalore 575018, India"},{"name":"School of Biotechnology, KIIT University d , Bhubaneswar, Odisha 751024, India"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560066, India \u00a0 keshav@ibioinformatics.org \u00a0 +91-80-28416132 \u00a0 +91-80-28416140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premendu P","family":"Mathur","sequence":"additional","affiliation":[{"name":"School of Biotechnology, KIIT University d , Bhubaneswar, Odisha 751024, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parthasarathy","family":"Satishchandra","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences h , Bangalore 560029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S K","family":"Shankar","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Human Brain Tissue Repository, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences j , Bangalore 560029, India \u00a0 anita_mahadevan@yahoo.com \u00a0 +91-80-26564830 \u00a0 +91-80-26995137"},{"name":"Department of Neuropathology, National Institute of Mental Health and Neurosciences i , Bangalore 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