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Here we describe the creation of a chemoproteomic library to discover a novel photoaffinity probe for DcpS, an mRNA decapping enzyme that is a putative target for Spinal Muscular Atrophy. This library approach expedites the discovery of photoaffinity probes and expands the chemical biology toolbox to include RNA cap-binding proteins.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c5mb00288e","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T12:30:29Z","timestamp":1430829029000},"page":"2709-2712","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS"],"prefix":"10.1093","volume":"11","author":[{"given":"Hua","family":"Xu","sequence":"first","affiliation":[{"name":"Worldwide Medicinal Chemistry, Pfizer Inc. a , 610 Main Street, Cambridge, MA 02139, USA \u00a0 Hua.Xu@pfizer.com \u00a0 Lyn.Jones@pfizer.com \u00a0 +1-617-674 2920"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik C","family":"Hett","sequence":"additional","affiliation":[{"name":"Worldwide Medicinal Chemistry, Pfizer Inc. a , 610 Main Street, Cambridge, MA 02139, USA \u00a0 Hua.Xu@pfizer.com \u00a0 Lyn.Jones@pfizer.com \u00a0 +1-617-674 2920"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariamala","family":"Gopalsamy","sequence":"additional","affiliation":[{"name":"Worldwide Medicinal Chemistry, Pfizer Inc. a , 610 Main Street, Cambridge, MA 02139, USA \u00a0 Hua.Xu@pfizer.com \u00a0 Lyn.Jones@pfizer.com \u00a0 +1-617-674 2920"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihir D","family":"Parikh","sequence":"additional","affiliation":[{"name":"Worldwide Medicinal Chemistry, Pfizer Inc. b , Eastern Point Road, Groton CT, 06340, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran F","family":"Geoghegan","sequence":"additional","affiliation":[{"name":"Structural Biology and Biophysics, Worldwide Medicinal Chemistry, Pfizer Inc. c , Eastern Point Road, Groton CT, 06340, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Robert E.","family":"Kyne","sequence":"additional","affiliation":[{"name":"Worldwide Medicinal Chemistry, Pfizer Inc. b , Eastern Point Road, Groton CT, 06340, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A","family":"Menard","sequence":"additional","affiliation":[{"name":"Primary Pharmacology Group, Pfizer Inc. d , Eastern Point Road, Groton CT, 06340, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Worldwide Medicinal Chemistry, Pfizer Inc. a , 610 Main Street, Cambridge, MA 02139, USA \u00a0 Hua.Xu@pfizer.com \u00a0 Lyn.Jones@pfizer.com \u00a0 +1-617-674 2920"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph P","family":"Robinson","sequence":"additional","affiliation":[{"name":"Worldwide Medicinal Chemistry, Pfizer Inc. b , Eastern Point Road, Groton CT, 06340, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas S","family":"Johnson","sequence":"additional","affiliation":[{"name":"Worldwide Medicinal Chemistry, Pfizer Inc. a , 610 Main Street, Cambridge, MA 02139, USA \u00a0 Hua.Xu@pfizer.com \u00a0 Lyn.Jones@pfizer.com \u00a0 +1-617-674 2920"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Tones","sequence":"additional","affiliation":[{"name":"Rare Disease Research Unit, Pfizer Inc. e , Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn H","family":"Jones","sequence":"additional","affiliation":[{"name":"Worldwide Medicinal Chemistry, Pfizer Inc. a , 610 Main Street, Cambridge, MA 02139, USA \u00a0 Hua.Xu@pfizer.com \u00a0 Lyn.Jones@pfizer.com \u00a0 +1-617-674 2920"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,5,5]]},"reference":[{"key":"2026010815115432500_cit1","doi-asserted-by":"crossref","first-page":"9990","DOI":"10.1021\/ja502780z","volume":"136","author":"Li","year":"2014","journal-title":"J. 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