{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:34:55Z","timestamp":1790688895167,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000106","name":"Saskatchewan Health Research Foundation","doi-asserted-by":"publisher","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/501100000106","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000106","name":"Saskatchewan Health Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000106","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The compounds of mercury can be more toxic than those of any other non-radioactive heavy element. Despite this, environmental mercury pollution and human exposure to mercury are widespread, and are increasing. While the unusual ability of selenium to cancel the toxicity of mercury compounds has been known for nearly five decades, only recently have some aspects of the molecular mechanisms begun to be understood. We report herein a study of the interaction of mercury and selenium in the larval stage zebrafish, a model vertebrate system, using X-ray fluorescence imaging. Exposure of larval zebrafish to inorganic mercury shows nano-scale structures containing co-localized mercury and selenium. No such co-localization is seen with methylmercury exposure under similar conditions. Micro X-ray absorption spectra support the hypothesis that the co-localized deposits are most likely comprised of highly insoluble mixed chalcogenide HgSxSe(1\u2212x) where x is 0.4\u20130.9, probably with the cubic zincblende structure.<\/jats:p>","DOI":"10.1039\/c5mt00145e","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T09:07:36Z","timestamp":1435741656000},"page":"1247-1255","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Interaction of mercury and selenium in the larval stage zebrafish vertebrate model"],"prefix":"10.1093","volume":"7","author":[{"given":"Tracy C","family":"MacDonald","sequence":"first","affiliation":[{"name":"Molecular and Environmental Science Research Group, Department of Geological Sciences, University of Saskatchewan , Saskatoon, SK, S7N 5E2, Canada"},{"name":"Toxicology Centre, University of Saskatchewan , Saskatoon, SK, S7N 5B3, Canada"},{"name":"Department of Anatomy and Cell Biology, University of Saskatchewan , Saskatoon, SK, S7N 5E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Korbas","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Saskatchewan , Saskatoon, SK, S7N 5E5, Canada"},{"name":"Canadian Light Source , 44 Innovation Boulevard, Saskatoon, SK, S7N 2V3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley K","family":"James","sequence":"additional","affiliation":[{"name":"Molecular and Environmental Science Research Group, Department of Geological Sciences, University of Saskatchewan , Saskatoon, SK, S7N 5E2, Canada"},{"name":"Toxicology Centre, University of Saskatchewan , Saskatoon, SK, S7N 5B3, Canada"},{"name":"Department of Anatomy and Cell Biology, University of Saskatchewan , Saskatoon, SK, S7N 5E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J","family":"Sylvain","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Saskatchewan , Saskatoon, SK, S7N 5E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Hackett","sequence":"additional","affiliation":[{"name":"Molecular and Environmental Science Research Group, Department of Geological Sciences, University of Saskatchewan , Saskatoon, SK, S7N 5E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Nehzati","sequence":"additional","affiliation":[{"name":"Molecular and Environmental Science Research Group, Department of Geological Sciences, University of Saskatchewan , Saskatoon, SK, S7N 5E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick H","family":"Krone","sequence":"additional","affiliation":[{"name":"Toxicology Centre, University of Saskatchewan , Saskatoon, SK, S7N 5B3, Canada"},{"name":"Department of Anatomy and Cell Biology, University of Saskatchewan , Saskatoon, SK, S7N 5E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham N","family":"George","sequence":"additional","affiliation":[{"name":"Molecular and Environmental Science Research Group, Department of Geological Sciences, University of Saskatchewan , Saskatoon, SK, S7N 5E2, Canada"},{"name":"Toxicology Centre, University of Saskatchewan , Saskatoon, SK, S7N 5B3, Canada"},{"name":"Department of Chemistry, University of Saskatchewan , Saskatoon, SK, S7N 5C9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid J","family":"Pickering","sequence":"additional","affiliation":[{"name":"Molecular and Environmental Science Research Group, Department of Geological Sciences, University of Saskatchewan , Saskatoon, SK, S7N 5E2, Canada"},{"name":"Toxicology Centre, University of Saskatchewan , Saskatoon, SK, S7N 5B3, Canada"},{"name":"Department of Chemistry, University of Saskatchewan , Saskatoon, SK, S7N 5C9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"2023081708362352200_cit1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/10408440600845619","article-title":"The toxicology of mercury and its chemical compounds","volume":"36","author":"Clarkson","year":"2006","journal-title":"Crit. 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Pickering (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/A-4547-2013","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Received 2 June 2015; Accepted 30 June 2015; Accepted Manuscript published 1 July 2015; Advance Article published 16 July 2015; Version of Record published 5 August 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}