{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T20:40:38Z","timestamp":1792356038474,"version":"4.4.0"},"reference-count":52,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21431006"],"award-info":[{"award-number":["21431006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21521001"],"award-info":[{"award-number":["21521001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31370983"],"award-info":[{"award-number":["31370983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"DOI":"10.1039\/c5nr06876b","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T04:31:33Z","timestamp":1447302693000},"page":"309-317","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Chitosan microspheres with an extracellular matrix-mimicking nanofibrous structure as cell-carrier building blocks for bottom-up cartilage tissue engineering"],"prefix":"10.1039","volume":"8","author":[{"given":"Yong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-Ling","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Bo","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Cai","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo-Hong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C5NR06876B-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S1369-7021(12)70197-9","volume":"15","author":"Wade","year":"2012","journal-title":"Mater. Today"},{"key":"C5NR06876B-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1126\/science.1106587","volume":"310","author":"Stevens","year":"2005","journal-title":"Science"},{"key":"C5NR06876B-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrm1858","volume":"7","author":"Griffith","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C5NR06876B-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/jcp.10471","volume":"199","author":"Rosso","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"C5NR06876B-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1091\/mbc.4.9.953","volume":"4","author":"Meredith","year":"1993","journal-title":"Mol. Biol. Cell"},{"key":"C5NR06876B-(cit6)\/*[position()=1]","first-page":"845","volume":"39","author":"Gullberg","year":"1995","journal-title":"Int. J. Dev. Biol."},{"key":"C5NR06876B-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/nmat3404","volume":"11","author":"Tian","year":"2012","journal-title":"Nat. Mater."},{"key":"C5NR06876B-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1016\/S0142-9612(00)00126-5","volume":"21","author":"Suh","year":"2000","journal-title":"Biomaterials"},{"key":"C5NR06876B-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1002\/adma.200600113","volume":"18","author":"Tang","year":"2006","journal-title":"Adv. Mater."},{"key":"C5NR06876B-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9622","DOI":"10.1016\/j.biomaterials.2011.09.009","volume":"32","author":"Holzwarth","year":"2011","journal-title":"Biomaterials"},{"key":"C5NR06876B-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0939-6411(03)00160-7","volume":"57","author":"Berger","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"C5NR06876B-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5526","DOI":"10.1016\/j.biomaterials.2010.03.065","volume":"31","author":"Smith","year":"2010","journal-title":"Biomaterials"},{"key":"C5NR06876B-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1002\/adma.201400523","volume":"26","author":"Shah","year":"2014","journal-title":"Adv. Mater."},{"key":"C5NR06876B-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.nantod.2014.10.002","volume":"9","author":"Wade","year":"2014","journal-title":"Nano Today"},{"key":"C5NR06876B-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1002\/adfm.201103083","volume":"22","author":"Kim","year":"2012","journal-title":"Adv. Funct. Mater."},{"key":"C5NR06876B-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.8493529","volume":"260","author":"Langer","year":"1993","journal-title":"Science"},{"key":"C5NR06876B-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.tcb.2012.09.004","volume":"22","author":"Liu","year":"2012","journal-title":"Trends Cell Biol."},{"key":"C5NR06876B-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.copbio.2011.04.001","volume":"22","author":"Elbert","year":"2011","journal-title":"Curr. Opin. Biotechnol."},{"key":"C5NR06876B-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/adhm.201400150","volume":"4","author":"Khan","year":"2015","journal-title":"Adv. Healthcare Mater."},{"key":"C5NR06876B-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.drudis.2014.10.018","volume":"20","author":"Onoe","year":"2015","journal-title":"Drug Discovery Today"},{"key":"C5NR06876B-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"H90","DOI":"10.1002\/adma.201004375","volume":"23","author":"Matsunaga","year":"2011","journal-title":"Adv. Mater."},{"key":"C5NR06876B-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1002\/adma.201304539","volume":"26","author":"Leferink","year":"2014","journal-title":"Adv. Mater."},{"key":"C5NR06876B-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/nmat2999","volume":"10","author":"Liu","year":"2011","journal-title":"Nat. Mater."},{"key":"C5NR06876B-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/anie.201410930","volume":"54","author":"Duan","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5NR06876B-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jconrel.2008.04.011","volume":"129","author":"Chan","year":"2008","journal-title":"J. Controlled Release"},{"key":"C5NR06876B-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1002\/adma.201501329","volume":"27","author":"Zhang","year":"2015","journal-title":"Adv. Mater."},{"key":"C5NR06876B-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biotechadv.2007.07.009","volume":"26","author":"Kim","year":"2008","journal-title":"Biotechnol. Adv."},{"key":"C5NR06876B-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.1016\/j.biomaterials.2005.03.016","volume":"26","author":"Di Martino","year":"2005","journal-title":"Biomaterials"},{"key":"C5NR06876B-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0012-1606(73)90018-3","volume":"35","author":"Kosher","year":"1973","journal-title":"Dev. Biol."},{"key":"C5NR06876B-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1002\/smll.201100514","volume":"7","author":"Jiang","year":"2011","journal-title":"Small"},{"key":"C5NR06876B-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/adhm.201100014","volume":"1","author":"Xu","year":"2012","journal-title":"Adv. Healthcare Mater."},{"key":"C5NR06876B-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10544-008-9230-3","volume":"11","author":"Xu","year":"2009","journal-title":"Biomed. Microdevices"},{"key":"C5NR06876B-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.snb.2007.01.015","volume":"124","author":"Yang","year":"2007","journal-title":"Sens. Actuators, B"},{"key":"C5NR06876B-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/mabi.201100502","volume":"12","author":"Tan","year":"2012","journal-title":"Macromol. Biosci."},{"key":"C5NR06876B-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature06619","volume":"452","author":"Ladet","year":"2008","journal-title":"Nature"},{"key":"C5NR06876B-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1021\/ar4001263","volume":"47","author":"Wang","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"C5NR06876B-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/ja310389w","volume":"135","author":"Zhao","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"C5NR06876B-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/smll.201201624","volume":"9","author":"Ma","year":"2013","journal-title":"Small"},{"key":"C5NR06876B-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nnano.2012.168","volume":"7","author":"Valencia","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"C5NR06876B-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11462","DOI":"10.1002\/anie.201303055","volume":"52","author":"Seiffert","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5NR06876B-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1038\/ncomms4068","volume":"5","author":"Kim","year":"2014","journal-title":"Nat. Commun."},{"key":"C5NR06876B-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11442","DOI":"10.1039\/c2jm16019f","volume":"22","author":"Choi","year":"2012","journal-title":"J. Mater. Chem."},{"key":"C5NR06876B-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1002\/adma.201305119","volume":"26","author":"Datta","year":"2014","journal-title":"Adv. Mater."},{"key":"C5NR06876B-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1002\/anie.201105730","volume":"51","author":"Cai","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5NR06876B-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/srep00849","volume":"2","author":"Jung","year":"2012","journal-title":"Sci. Rep."},{"key":"C5NR06876B-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.supflu.2012.02.026","volume":"66","author":"Garcia-Gonzalez","year":"2012","journal-title":"J. Supercrit. Fluids"},{"key":"C5NR06876B-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1126\/science.1109164","volume":"308","author":"Utada","year":"2005","journal-title":"Science"},{"key":"C5NR06876B-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.1021\/ja200729w","volume":"133","author":"Zhao","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C5NR06876B-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1016\/S0032-3861(99)00685-0","volume":"41","author":"Qu","year":"2000","journal-title":"Polymer"},{"key":"C5NR06876B-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0928-0987(02)00029-5","volume":"15","author":"Khalid","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"C5NR06876B-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0142-9612(89)90066-5","volume":"10","author":"Hirano","year":"1989","journal-title":"Biomaterials"},{"key":"C5NR06876B-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.actbio.2008.11.025","volume":"5","author":"Thein-Han","year":"2009","journal-title":"Acta Biomater."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/NR\/C5NR06876B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:34:00Z","timestamp":1782880440000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/8\/1\/309-317\/486042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c5nr06876b","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is CrossCheck deposited","name":"crosscheck","explanation":{"URL":"http:\/\/www.crossref.org\/crosscheck\/index.html"},"group":{"name":"crosscheck","label":"CROSSCHECK"}},{"value":"Supplementary Information","URL":"http:\/\/dx.doi.org\/10.1039\/C5NR06876B","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Received 5 October 2015; Accepted 10 November 2015; Accepted Manuscript published 12 November 2015; Advance Article published 27 November 2015; Version of Record published 17 December 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}