{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:24:20Z","timestamp":1791584660494,"version":"4.3.4"},"reference-count":37,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"crossref","award":["ZIA EB000073"],"award-info":[{"award-number":["ZIA EB000073"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<p>Cancer evolves to evade or compromise the surveillance of the immune system, and nanoimmunotherapeutics were developed to reactivate the immune system in order to inhibit cancer development.<\/p>","DOI":"10.1039\/c5nr08821f","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T05:38:00Z","timestamp":1456205880000},"page":"6684-6692","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["DNA\u2013inorganic hybrid nanovaccine for cancer immunotherapy"],"prefix":"10.1039","volume":"8","author":[{"given":"Guizhi","family":"Zhu","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine"},{"name":"National Institute of Biomedical Imaging and Bioengineering (NIBIB)"},{"name":"National Institutes of Health (NIH)"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine"},{"name":"National Institute of Biomedical Imaging and Bioengineering (NIBIB)"},{"name":"National Institutes of Health (NIH)"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine"},{"name":"National Institute of Biomedical Imaging and Bioengineering (NIBIB)"},{"name":"National Institutes of Health (NIH)"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hwa","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine"},{"name":"National Institute of Biomedical Imaging and Bioengineering (NIBIB)"},{"name":"National Institutes of Health (NIH)"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine"},{"name":"National Institute of Biomedical Imaging and Bioengineering (NIBIB)"},{"name":"National Institutes of Health (NIH)"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Jia","sequence":"additional","affiliation":[{"name":"Section on Intracellular Protein Trafficking"},{"name":"Cell Biology and Metabolism Program"},{"name":"National Institute of Child Health and Human Development"},{"name":"NIH"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien-Shun","family":"Liao","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Imaging and Macromolecular Biophysics"},{"name":"NIBIB"},{"name":"NIH"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Jin","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Imaging and Macromolecular Biophysics"},{"name":"NIBIB"},{"name":"NIH"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Imaging and Macromolecular Biophysics"},{"name":"NIBIB"},{"name":"NIH"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Aronova","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Imaging and Macromolecular Biophysics"},{"name":"NIBIB"},{"name":"NIH"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Leapman","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Imaging and Macromolecular Biophysics"},{"name":"NIBIB"},{"name":"NIH"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of Maryland"},{"name":"College Park, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Niu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine"},{"name":"National Institute of Biomedical Imaging and Bioengineering (NIBIB)"},{"name":"National Institutes of Health (NIH)"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine"},{"name":"National Institute of Biomedical Imaging and Bioengineering (NIBIB)"},{"name":"National Institutes of Health (NIH)"},{"name":"Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C5NR08821F-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrc3258","volume":"12","author":"Palucka","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"C5NR08821F-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrc3246","volume":"12","author":"Thomas","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"C5NR08821F-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nm1100","volume":"10","author":"Rosenberg","year":"2004","journal-title":"Nat. Med."},{"key":"C5NR08821F-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.aaa8172","volume":"348","author":"Sharma","year":"2015","journal-title":"Science"},{"key":"C5NR08821F-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nri1329","volume":"4","author":"Klinman","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"C5NR08821F-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9305","DOI":"10.1073\/pnas.96.16.9305","volume":"96","author":"Hartmann","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5NR08821F-(cit7)\/*[position()=1]","first-page":"7","author":"Gregory","year":"2005","journal-title":"Nat. Immunol."},{"key":"C5NR08821F-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/icb.2008.101","volume":"87","author":"Chockalingam","year":"2008","journal-title":"Immunol. Cell Biol."},{"key":"C5NR08821F-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ni1028","volume":"5","author":"Latz","year":"2004","journal-title":"Nat. Immunol."},{"key":"C5NR08821F-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1073\/pnas.93.7.2879","volume":"93","author":"Klinman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5NR08821F-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nrd2059","volume":"5","author":"Krieg","year":"2006","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C5NR08821F-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6377","DOI":"10.1016\/j.vaccine.2014.06.065","volume":"32","author":"Scheiermann","year":"2014","journal-title":"Vaccine"},{"key":"C5NR08821F-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.4049\/jimmunol.172.3.1777","volume":"172","author":"Storni","year":"2004","journal-title":"J. Immunol."},{"key":"C5NR08821F-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.4049\/jimmunol.162.4.2368","volume":"162","author":"Sparwasser","year":"1999","journal-title":"J. Immunol."},{"key":"C5NR08821F-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature12978","volume":"507","author":"Liu","year":"2014","journal-title":"Nature"},{"key":"C5NR08821F-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1002\/anie.201101266","volume":"50","author":"Liu","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5NR08821F-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/nmat3775","volume":"12","author":"Irvine","year":"2013","journal-title":"Nat. Mater."},{"key":"C5NR08821F-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1021\/acsnano.5b02153","volume":"9","author":"Zhang","year":"2015","journal-title":"ACS Nano"},{"key":"C5NR08821F-(cit19)\/*[position()=1]","first-page":"2018197663","author":"Darrell","year":"2015","journal-title":"Chem. Rev."},{"key":"C5NR08821F-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19902","DOI":"10.1073\/pnas.1313152110","author":"Titta","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5NR08821F-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E797","DOI":"10.1073\/pnas.1121423109","volume":"109","author":"Nguyen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5NR08821F-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1021\/nl301877k","volume":"12","author":"Liu","year":"2012","journal-title":"Nano Lett."},{"key":"C5NR08821F-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9670","DOI":"10.1002\/anie.201204989","volume":"51","author":"Kim","year":"2012","journal-title":"Angew. Chem., Int. Ed"},{"key":"C5NR08821F-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.biomaterials.2010.09.013","volume":"32","author":"Nishikawa","year":"2011","journal-title":"Biomaterials"},{"key":"C5NR08821F-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1021\/nn202774x","volume":"5","author":"Li","year":"2011","journal-title":"ACS Nano"},{"key":"C5NR08821F-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16438","DOI":"10.1021\/ja406115e","volume":"135","author":"Zhu","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"C5NR08821F-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nmat3253","volume":"11","author":"Lee","year":"2012","journal-title":"Nat. Mater."},{"key":"C5NR08821F-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24069","DOI":"10.1021\/acsami.5b06987","author":"Zhang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C5NR08821F-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/nprot.2015.078","volume":"10","author":"Lv","year":"2015","journal-title":"Nat. Protoc."},{"key":"C5NR08821F-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1073\/pnas.0804897106","volume":"106","author":"Sharp","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5NR08821F-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9767","DOI":"10.1021\/nn502596b","volume":"8","author":"Roh","year":"2014","journal-title":"ACS Nano"},{"key":"C5NR08821F-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/smll.201302676","volume":"10","author":"Kevin","year":"2014","journal-title":"Small"},{"key":"C5NR08821F-(cit33)\/*[position()=1]","author":"FDA","year":"2011","unstructured":"FDA , 2011"},{"key":"C5NR08821F-(cit34)\/*[position()=1]","author":"FDA","year":"2011","unstructured":"FDA , 2011"},{"key":"C5NR08821F-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/clinchem\/41.10.1522","author":"Fogh-Andersen","year":"1995","journal-title":"Clin. Chem."},{"key":"C5NR08821F-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.4049\/jimmunol.177.7.4473","volume":"177","author":"Sester","year":"2006","journal-title":"J. Immunol."},{"key":"C5NR08821F-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/jmcb\/mjt022","volume":"5","author":"Appelqvist","year":"2013","journal-title":"J. Mol. Cell Biol."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/NR\/C5NR08821F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:25:09Z","timestamp":1782966309000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/8\/12\/6684-6692\/486556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c5nr08821f","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is CrossCheck deposited","name":"crosscheck","explanation":{"URL":"http:\/\/www.crossref.org\/crosscheck\/index.html"},"group":{"name":"crosscheck","label":"CROSSCHECK"}},{"value":"Supplementary Information","URL":"http:\/\/dx.doi.org\/10.1039\/C5NR08821F","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Albert Jin (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/F-2553-2011","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Received 11 December 2015; Accepted 22 February 2016; Accepted Manuscript published 23 February 2016; Advance Article published 7 March 2016; Version of Record published 17 March 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}