{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:59:46Z","timestamp":1787003986762,"version":"build-2736575974"},"reference-count":38,"publisher":"Royal Society of Chemistry (RSC)","issue":"24","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>First prodrug-like analogs of highly ionic inhibitors of RGGT were obtained and their chemical and enzymatic stability was evaluated.<\/p>","DOI":"10.1039\/c5ob00281h","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T06:32:02Z","timestamp":1430807522000},"page":"6844-6856","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Applying the prodrug strategy to \u03b1-phosphonocarboxylate inhibitors of Rab GGTase \u2013 synthesis and stability studies"],"prefix":"10.1039","volume":"13","author":[{"given":"\u0141ukasz","family":"Joachimiak","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry"},{"name":"Lodz University of Technology"},{"name":"90-924 \u0141\u00f3d\u017a"},{"name":"Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Janczewski","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry"},{"name":"Lodz University of Technology"},{"name":"90-924 \u0141\u00f3d\u017a"},{"name":"Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Ciekot","sequence":"additional","affiliation":[{"name":"\u201cNeolek\u201d \u2013 Department of Experimental Oncology"},{"name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy"},{"name":"Polish Academy of Sciences"},{"name":"53-144 Wroclaw"},{"name":"Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Boraty\u0144ski","sequence":"additional","affiliation":[{"name":"\u201cNeolek\u201d \u2013 Department of Experimental Oncology"},{"name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy"},{"name":"Polish Academy of Sciences"},{"name":"53-144 Wroclaw"},{"name":"Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"B\u0142a\u017cewska","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry"},{"name":"Lodz University of Technology"},{"name":"90-924 \u0141\u00f3d\u017a"},{"name":"Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C5OB00281H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8330","DOI":"10.1021\/jm300624s","volume":"55","author":"Stigter","year":"2012","journal-title":"J. Med. Chem."},{"key":"C5OB00281H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1002\/anie.200705795","volume":"47","author":"Guo","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5OB00281H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7384","DOI":"10.1021\/ja211305j","volume":"134","author":"Deraeve","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"C5OB00281H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1002\/anie.201101210","volume":"50","author":"Bon","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5OB00281H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1021\/jm900232u","volume":"53","author":"McKenna","year":"2010","journal-title":"J. Med. Chem."},{"key":"C5OB00281H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9571","DOI":"10.1074\/jbc.M706229200","volume":"283","author":"Watanabe","year":"2008","journal-title":"J. Biol. Chem."},{"key":"C5OB00281H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1039\/C2MD20299A","volume":"4","author":"Ochocki","year":"2013","journal-title":"MedChemComm"},{"key":"C5OB00281H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1042\/BST20120203","volume":"40","author":"Kelly","year":"2012","journal-title":"Biochem. Soc. Trans."},{"key":"C5OB00281H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1042\/BST20120199","volume":"40","author":"Recchi","year":"2012","journal-title":"Biochem. Soc. Trans."},{"key":"C5OB00281H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejmech.2014.06.062","volume":"84","author":"Coxon","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"C5OB00281H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1021\/jm701260b","volume":"51","author":"Hecker","year":"2008","journal-title":"J. Med. Chem."},{"key":"C5OB00281H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9154","DOI":"10.1021\/cr5002035","volume":"114","author":"Pradere","year":"2014","journal-title":"Chem. Rev."},{"key":"C5OB00281H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3851\/IMP2012","volume":"22","author":"Pertusati","year":"2012","journal-title":"Antiviral Chem. Chemother."},{"key":"C5OB00281H-(cit15)\/*[position()=1]","unstructured":"U.S. Food and Drug Administration, http:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm418365.htm"},{"key":"C5OB00281H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2174\/1389200033489253","volume":"4","author":"Beaumont","year":"2003","journal-title":"Curr. Drug Metab."},{"key":"C5OB00281H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1021\/jm0702884","volume":"50","author":"Marma","year":"2007","journal-title":"J. Med. Chem."},{"key":"C5OB00281H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1016\/j.ejmech.2011.04.063","volume":"46","author":"B\u0142a\u017cewska","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"C5OB00281H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0040-4039(01)92575-4","author":"McKenna","year":"1977","journal-title":"Tetrahedron Lett."},{"key":"C5OB00281H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1039\/c39790000739","author":"McKenna","year":"1979","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"C5OB00281H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1021\/jo4021612","volume":"79","author":"B\u0142a\u017cewska","year":"2014","journal-title":"J. Org. Chem."},{"key":"C5OB00281H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1021\/jm8011799","volume":"52","author":"Baudy","year":"2009","journal-title":"J. Med. Chem."},{"key":"C5OB00281H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1002\/ejoc.201101111","author":"Pradere","year":"2011","journal-title":"Eur. J. Org. Chem."},{"key":"C5OB00281H-(cit24)\/*[position()=1]","first-page":"129","author":"Katayama","year":"2006","journal-title":"Synlett"},{"key":"C5OB00281H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1080\/00397918708078788","volume":"17","author":"Bhongle","year":"1987","journal-title":"Synth. Commun."},{"key":"C5OB00281H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/S0040-4020(00)01143-1","volume":"57","author":"Sikora","year":"2001","journal-title":"Tetrahedron"},{"key":"C5OB00281H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1080\/00397919908085948","volume":"29","author":"Misra","year":"1999","journal-title":"Synth. Commun."},{"key":"C5OB00281H-(cit28)\/*[position()=1]","volume-title":"Accounts in Drug Discovery: Case Studies in Medicinal Chemistry","author":"Mackman","year":"2010","unstructured":"R.\n            Mackman\n          , in Accounts in Drug Discovery: Case Studies in Medicinal Chemistry, ed. P. C. Joel Barrish, Peter Cheng and Robert Zahler, RSC Publishing, Cambridge, 2010, ch. 10, pp. 215\u2013237"},{"key":"C5OB00281H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0045-2068(84)90022-1","volume":"12","author":"Srivastva","year":"1984","journal-title":"Bioorg. Chem."},{"key":"C5OB00281H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1021\/jo9005987","volume":"74","author":"Ora","year":"2009","journal-title":"J. Org. Chem."},{"key":"C5OB00281H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1128\/AAC.00968-06","volume":"51","author":"Birkus","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"C5OB00281H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1016\/j.bmc.2010.03.041","volume":"18","author":"Mackman","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"C5OB00281H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8632","DOI":"10.1021\/jm2011673","volume":"54","author":"McGuigan","year":"2011","journal-title":"J. Med. Chem."},{"key":"C5OB00281H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ejmech.2013.09.047","volume":"70","author":"McGuigan","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"C5OB00281H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/cmdc.200900289","volume":"4","author":"Mehellou","year":"2009","journal-title":"ChemMedChem"},{"key":"C5OB00281H-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9003","DOI":"10.1021\/bi025942q","volume":"41","author":"Brenner","year":"2002","journal-title":"Biochemistry"},{"key":"C5OB00281H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.jmb.2007.08.023","volume":"373","author":"Chou","year":"2007","journal-title":"J. Mol. Biol."},{"key":"C5OB00281H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1021\/mp060070y","volume":"4","author":"Chou","year":"2007","journal-title":"Mol. Pharmaceutics"},{"key":"C5OB00281H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1021\/jm2001426","volume":"54","author":"Zakharova","year":"2011","journal-title":"J. Med. Chem."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/OB\/C5OB00281H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:18:53Z","timestamp":1782929933000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/13\/24\/6844-6856\/487022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":38,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c5ob00281h","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C5OB00281H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"\u0141ukasz Joachimiak (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/O-3344-2014","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 9 February 2015; Accepted 5 May 2015;  Accepted Manuscript published 5 May 2015;  Advance Article published 28 May 2015;  Version of Record published 10 June 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}