{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:07:35Z","timestamp":1791828455209,"version":"4.3.4"},"reference-count":59,"publisher":"Royal Society of Chemistry (RSC)","issue":"23","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>A series of 2\/3\/4-[(2-oxo-1,2-dihydro-3<italic>H<\/italic>-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide, showed low nanomolar inhibitory activity against the tumor associated carbonic anhydrases IX and XII.<\/p>","DOI":"10.1039\/c5ob00688k","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T15:26:12Z","timestamp":1430148372000},"page":"6493-6499","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII"],"prefix":"10.1039","volume":"13","author":[{"given":"\u00d6zlen","family":"G\u00fczel-Akdemir","sequence":"first","affiliation":[{"name":"Istanbul University"},{"name":"Faculty of Pharmacy"},{"name":"Department of Pharmaceutical Chemistry"},{"name":"Istanbul"},{"name":"Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla","family":"Akdemir","sequence":"additional","affiliation":[{"name":"Bezmialem Vakif University"},{"name":"Faculty of Pharmacy"},{"name":"Department of Pharmacology"},{"name":"Istanbul"},{"name":"Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilg\u00fcn","family":"Karal\u0131","sequence":"additional","affiliation":[{"name":"Istanbul University"},{"name":"Faculty of Pharmacy"},{"name":"Department of Pharmaceutical Chemistry"},{"name":"Istanbul"},{"name":"Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Universita degli Studi di Firenze"},{"name":"NEUROFARBA Dept."},{"name":"Sezione di Scienze Farmaceutiche"},{"name":"Sesto Fiorentino (Florence)"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C5OB00688K-(cit1a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C5OB00688K-(cit1b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1517\/13543776.2013.782394","volume":"23","author":"Aggarwal","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"C5OB00688K-(cit1c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1039\/C5CC01854D","volume":"51","author":"Ivanova","year":"2015","journal-title":"Chem. Commun."},{"key":"C5OB00688K-(cit2a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem. Rev."},{"key":"C5OB00688K-(cit2b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C5OB00688K-(cit2c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/14756366.2014.910202","volume":"30","author":"Capasso","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit3a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/14756366.2013.761876","volume":"28","author":"Supuran","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit3b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s007750050375","volume":"4","author":"Briganti","year":"1999","journal-title":"J. Biol. Inorg. Chem."},{"key":"C5OB00688K-(cit3c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jinorgbio.2011.11.017","volume":"111","author":"De Simone","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"C5OB00688K-(cit3d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1039\/C4CC07320G","volume":"51","author":"D'Ambrosio","year":"2015","journal-title":"Chem. Commun."},{"key":"C5OB00688K-(cit4a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1021\/ml500470b","volume":"6","author":"Tanc","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"C5OB00688K-(cit4b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.bmcl.2008.03.012","volume":"18","author":"Innocenti","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C5OB00688K-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.bmc.2013.02.026","volume":"21","author":"Supuran","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"C5OB00688K-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit5c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0960-894X(00)00722-8","volume":"11","author":"Scozzafava","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C5OB00688K-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1517\/17460441.2013.795145","volume":"8","author":"De Simone","year":"2013","journal-title":"Expert Opin. Drug Discovery"},{"key":"C5OB00688K-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1016\/j.bmcl.2014.08.015","volume":"24","author":"Del Prete","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C5OB00688K-(cit8a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1021\/jm4000616","volume":"56","author":"Pan","year":"2013","journal-title":"J. Med. Chem."},{"key":"C5OB00688K-(cit8b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7372","DOI":"10.1021\/jm400939k","volume":"56","author":"Syrjanen","year":"2013","journal-title":"J. Med. Chem."},{"key":"C5OB00688K-(cit8c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/jm0512600","volume":"49","author":"Nishimori","year":"2006","journal-title":"J. Med. Chem."},{"key":"C5OB00688K-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1517\/13543776.2013.780598","volume":"23","author":"Carta","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"C5OB00688K-(cit10a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/13543776.2013.794788","volume":"23","author":"Masini","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"C5OB00688K-(cit10b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1021\/jm501314c","volume":"57","author":"Bozdag","year":"2014","journal-title":"J. Med. Chem."},{"key":"C5OB00688K-(cit10c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1021\/jm501497m","volume":"57","author":"Bozdag","year":"2014","journal-title":"J. Med. Chem."},{"key":"C5OB00688K-(cit11a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1747-0285.2009.00857.x","volume":"74","author":"De Simone","year":"2009","journal-title":"Chem. Biol. Drug Des."},{"key":"C5OB00688K-(cit11b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/jm901524f","volume":"53","author":"Temperini","year":"2010","journal-title":"J. Med. Chem."},{"key":"C5OB00688K-(cit11c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/1475636031000071817","volume":"18","author":"Chohan","year":"2003","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit12a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1517\/13543776.2012.698264","volume":"22","author":"Carta","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"C5OB00688K-(cit12b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1517\/14728214.2012.664132","volume":"17","author":"Supuran","year":"2012","journal-title":"Expert Opin. Emerging Drugs"},{"key":"C5OB00688K-(cit13a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1002\/anie.201310709","volume":"53","author":"Krall","year":"2014","journal-title":"Angew. Chem., Int. Ed.."},{"key":"C5OB00688K-(cit13b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"84","DOI":"10.18632\/oncotarget.422","volume":"3","author":"McDonald","year":"2012","journal-title":"Oncotarget"},{"key":"C5OB00688K-(cit13c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1038\/onc.2012.550","volume":"32","author":"Lock","year":"2013","journal-title":"Oncogene"},{"key":"C5OB00688K-(cit13d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.radonc.2007.04.018","volume":"83","author":"Dubois","year":"2007","journal-title":"Radiother. Oncol."},{"key":"C5OB00688K-(cit14a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20473","DOI":"10.1074\/jbc.M801330200","volume":"283","author":"Swietach","year":"2008","journal-title":"J. Biol. Chem."},{"key":"C5OB00688K-(cit14b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0908301106","volume":"106","author":"Alterio","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5OB00688K-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/14756366.2013.773994","volume":"29","author":"Pan","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit17a)\/*[position()=1]","volume-title":"Carbonic Anhydrase: Mechanism, regulation, Links to Disease, and Industrial Applications","author":"McKenna","year":"2014","unstructured":"R. McKenna and C. T.Supuran, Carbonic anhydrase inhibitors drug design, in Carbonic Anhydrase: Mechanism, regulation, Links to Disease, and Industrial Applications, ed. R. McKenna and S. Frost, Springer Verlag, Heidelberg, 2014, pp. 291\u2013323 (Subcell. Biochem. 2014, 75, 291)"},{"key":"C5OB00688K-(cit17b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0223-5234(98)80042-1","volume":"33","author":"Supuran","year":"1998","journal-title":"Eur. J. Med. Chem."},{"key":"C5OB00688K-(cit17c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2174\/156802607780636726","volume":"7","author":"Thiry","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"C5OB00688K-(cit18a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3109\/14756366.2013.787422","volume":"29","author":"Capasso","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit18b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.bmc.2014.12.030","volume":"23","author":"Mahon","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"C5OB00688K-(cit19a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0223-5234(96)85163-4","volume":"31","author":"Supuran","year":"1996","journal-title":"Eur. J. Med. Chem."},{"key":"C5OB00688K-(cit19b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1016\/j.bmcl.2005.04.055","volume":"15","author":"Puccetti","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C5OB00688K-(cit20a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6014","DOI":"10.1016\/j.bmcl.2009.09.047","volume":"19","author":"Nasr","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C5OB00688K-(cit20b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1021\/jm900449v","volume":"52","author":"Nasr","year":"2009","journal-title":"J. Med. Chem."},{"key":"C5OB00688K-(cit20c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8043","DOI":"10.1039\/C4CC03289F","volume":"50","author":"Abdelrahim","year":"2014","journal-title":"Chem. Commun."},{"key":"C5OB00688K-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0928-0987(01)00197-X","volume":"14","author":"Selvam","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"C5OB00688K-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/14756360410001689595","volume":"19","author":"Hassan","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/aoc.1134","volume":"20","author":"Chohan","year":"2006","journal-title":"Appl. Organomet. Chem."},{"key":"C5OB00688K-(cit24)\/*[position()=1]","first-page":"95","volume":"5","author":"Muthukumar","year":"2013","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"C5OB00688K-(cit25)\/*[position()=1]","first-page":"251","volume":"2","author":"Ramachandran","year":"2011","journal-title":"Int. J. Pharm. Biosci."},{"key":"C5OB00688K-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"C5OB00688K-(cit27a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3109\/14756366.2014.912215","volume":"30","author":"Sahin","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit27b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/14756366.2012.750311","volume":"29","author":"Akbaba","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3109\/14756366.2011.638921","volume":"27","author":"Liu","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit29a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3109\/14756366.2013.822371","volume":"29","author":"Del Prete","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit29b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/14756366.2014.917085","volume":"30","author":"De Luca","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C5OB00688K-(cit29c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.2174\/092986707782360141","volume":"14","author":"Mastrolorenzo","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"C5OB00688K-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1039\/C4OB02648A","volume":"13","author":"Alterio","year":"2015","journal-title":"Org. Biomol. Chem."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/OB\/C5OB00688K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T21:16:34Z","timestamp":1713388594000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=C5OB00688K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":59,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c5ob00688k","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)","URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 7 April 2015; Accepted 27 April 2015; Accepted Manuscript published 27 April 2015; Advance Article published 13 May 2015; Version of Record published 2 June 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}