{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:34:17Z","timestamp":1791851657622,"version":"4.3.4"},"reference-count":57,"publisher":"Royal Society of Chemistry (RSC)","issue":"45","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>A solution phase synthesis of peptide nucleic acid monomers and dimers was developed by using microwave-promoted Ugi multicomponent reactions.<\/p>","DOI":"10.1039\/c5ob01604e","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T13:02:28Z","timestamp":1441890148000},"page":"11052-11071","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Synthesis and structural characterization of monomeric and dimeric peptide nucleic acids prepared by using microwave-promoted multicomponent reactions"],"prefix":"10.1039","volume":"13","author":[{"given":"Reuben","family":"Ovadia","sequence":"first","affiliation":[{"name":"Laboratoire d'Architecture et Fonction des Macromol\u00e9cules Biologiques"},{"name":"Universit\u00e9 Aix-Marseille UMR CNRS 7257"},{"name":"Equipe \u201cAntiviral Medicinal Chemistry\u201d"},{"name":"Parc scientifique de Luminy"},{"name":"13288 Marseille Cedex 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Lebrun","sequence":"additional","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron (IBMM)"},{"name":"UMR 5247 CNRS - Universit\u00e9 Montpellier-ENSCM"},{"name":"Laboratoire de Mesures Physiques - Plateau Technique"},{"name":"34095 Montpellier Cedex 5"},{"name":"France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Barvik","sequence":"additional","affiliation":[{"name":"Institute of Physics"},{"name":"Faculty of Mathematics and Physics"},{"name":"Charles University"},{"name":"Prague 2"},{"name":"Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Vasseur","sequence":"additional","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron (IBMM)"},{"name":"UMR 5247 CNRS - Universit\u00e9 Montpellier-ENSCM"},{"name":"Equipe \u201cOligonucl\u00e9otides Modifi\u00e9s\u201d"},{"name":"34095 Montpellier Cedex 5"},{"name":"France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Baraguey","sequence":"additional","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron (IBMM)"},{"name":"UMR 5247 CNRS - Universit\u00e9 Montpellier-ENSCM"},{"name":"Equipe \u201cOligonucl\u00e9otides Modifi\u00e9s\u201d"},{"name":"34095 Montpellier Cedex 5"},{"name":"France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Laboratoire d'Architecture et Fonction des Macromol\u00e9cules Biologiques"},{"name":"Universit\u00e9 Aix-Marseille UMR CNRS 7257"},{"name":"Equipe \u201cAntiviral Medicinal Chemistry\u201d"},{"name":"Parc scientifique de Luminy"},{"name":"13288 Marseille Cedex 9"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C5OB01604E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6608","DOI":"10.1021\/jm100102v","volume":"53","author":"Priet","year":"2010","journal-title":"J. Med. Chem."},{"key":"C5OB01604E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5745","DOI":"10.1021\/jm800617c","volume":"51","author":"Zlatev","year":"2008","journal-title":"J. Med. Chem."},{"key":"C5OB01604E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.1962210","volume":"254","author":"Nielsen","year":"1991","journal-title":"Science"},{"key":"C5OB01604E-(cit4)\/*[position()=1]","first-page":"25","volume":"1","author":"Rathee","year":"2012","journal-title":"Pharma Innovation"},{"key":"C5OB01604E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1517\/13543776.2014.863874","volume":"24","author":"Gambari","year":"2014","journal-title":"Expert Opin. Ther. Pat."},{"key":"C5OB01604E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1021\/jo00098a042","volume":"59","author":"Dueholm","year":"1994","journal-title":"J. Org. Chem."},{"key":"C5OB01604E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/0040-4039(96)00037-8","volume":"37","author":"Farese","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"C5OB01604E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0040-4020(98)01211-3","volume":"55","author":"Di Giorgio","year":"1999","journal-title":"Tetrahedron"},{"key":"C5OB01604E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1080\/07328319808004699","volume":"17","author":"D\u00f6mling","year":"1998","journal-title":"Nucleosides Nucleotides"},{"key":"C5OB01604E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/S0960-894X(99)00491-6","volume":"9","author":"Domling","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C5OB01604E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0968-0896(00)00066-3","volume":"8","author":"Maison","year":"2000","journal-title":"Bioorg. Med. Chem."},{"key":"C5OB01604E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0960-894X(99)00024-4","volume":"9","author":"Maison","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C5OB01604E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1055\/s-2003-39391","author":"Xu","year":"2003","journal-title":"Synthesis"},{"key":"C5OB01604E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1021\/cr0505728","volume":"106","author":"Domling","year":"2006","journal-title":"Chem. Rev."},{"key":"C5OB01604E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U","volume":"39","author":"Domling","year":"2000","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5OB01604E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/138620730101220118143111","volume":"1","author":"Domling","year":"1998","journal-title":"Comb. Chem. High Throughput Screening"},{"key":"C5OB01604E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12069","DOI":"10.1016\/0040-4020(95)00766-2","volume":"51","author":"Will","year":"1995","journal-title":"Tetrahedron"},{"key":"C5OB01604E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1016\/S0040-4020(02)00527-6","volume":"58","author":"Schwergold","year":"2002","journal-title":"Tetrahedron"},{"key":"C5OB01604E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.tetlet.2008.01.031","volume":"49","author":"Shinozuka","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"C5OB01604E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8660","DOI":"10.1016\/j.bmc.2010.09.069","volume":"18","author":"Riva","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"C5OB01604E-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/psc.333","volume":"7","author":"Kofoed","year":"2001","journal-title":"J. Pept. Sci."},{"key":"C5OB01604E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1002\/anie.199626321","volume":"35","author":"Uhlmann","year":"1996","journal-title":"Angew. Chem., Int. Ed."},{"key":"C5OB01604E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1093\/nar\/24.17.3357","volume":"24","author":"Finn","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"C5OB01604E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1139\/v75-419","volume":"53","author":"Hanessian","year":"1975","journal-title":"Can. J. Chem."},{"key":"C5OB01604E-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13369","DOI":"10.1016\/S0040-4020(01)89344-3","volume":"50","author":"Hatakeyama","year":"1994","journal-title":"Tetrahedron"},{"key":"C5OB01604E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0040-4020(01)92022-8","volume":"37","author":"K\u00f6ster","year":"1981","journal-title":"Tetrahedron"},{"key":"C5OB01604E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1021\/ja00906a021","volume":"85","author":"Schaller","year":"1963","journal-title":"J. Am. Chem. Soc."},{"key":"C5OB01604E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14671","DOI":"10.1016\/S0040-4020(97)01044-2","volume":"53","author":"Breipohl","year":"1997","journal-title":"Tetrahedron"},{"key":"C5OB01604E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/bip.20135","volume":"76","author":"Musumeci","year":"2004","journal-title":"Pept. Sci."},{"key":"C5OB01604E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1021\/ja971983b","volume":"120","author":"Clivio","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"C5OB01604E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1081\/NCN-100002564","volume":"20","author":"Oleszczuk","year":"2001","journal-title":"Nucleosides, Nucleotides Nucleic Acids"},{"key":"C5OB01604E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1016\/S0040-4039(00)77039-0","volume":"35","author":"Chen","year":"1994","journal-title":"Tetrahedron Lett."},{"key":"C5OB01604E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9147","DOI":"10.3390\/molecules18089147","volume":"18","author":"Gaglione","year":"2013","journal-title":"Molecules"},{"key":"C5OB01604E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1002\/hlca.201100243","volume":"94","author":"Pl\u00f6ger","year":"2011","journal-title":"Helv. Chim. Acta"},{"key":"C5OB01604E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.7519361","volume":"265","author":"Brown","year":"1994","journal-title":"Science"},{"key":"C5OB01604E-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13264","DOI":"10.1021\/ja800652h","volume":"130","author":"He","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"C5OB01604E-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0006-291X(83)91225-1","volume":"117","author":"Rance","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C5OB01604E-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1126\/science.3518060","volume":"232","author":"Bax","year":"1986","journal-title":"Science"},{"key":"C5OB01604E-(cit39)\/*[position()=1]","first-page":"565","volume":"67","author":"Bax","year":"1986","journal-title":"J. Magn. Reson."},{"key":"C5OB01604E-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0009-2614(80)80041-8","volume":"69","author":"Bodenhausen","year":"1980","journal-title":"Chem. Phys. Lett."},{"key":"C5OB01604E-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1021\/ja00315a069","volume":"106","author":"Bothner-By","year":"1984","journal-title":"J. Am. Chem. Soc."},{"key":"C5OB01604E-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e35774","DOI":"10.1371\/journal.pone.0035774","volume":"7","author":"Avitabile","year":"2012","journal-title":"PLoS One"},{"key":"C5OB01604E-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1126\/science.270.5243.1838","author":"Betts","year":"1995","journal-title":"Science"},{"key":"C5OB01604E-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7518","DOI":"10.1073\/pnas.90.16.7518","volume":"90","author":"Almarsson","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5OB01604E-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1529\/biophysj.105.079723","volume":"92","author":"Topham","year":"2007","journal-title":"Biophys. J."},{"key":"C5OB01604E-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1021\/ja0032632","volume":"123","author":"Sen","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"C5OB01604E-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e35774","DOI":"10.1371\/journal.pone.0035774","volume":"7","author":"Avitabile","year":"2012","journal-title":"PLoS One"},{"key":"C5OB01604E-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00211777","volume":"6","author":"Wishart","year":"1995","journal-title":"J. Biomol. NMR"},{"key":"C5OB01604E-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"key":"C5OB01604E-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"key":"C5OB01604E-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/jcc.10128","volume":"23","author":"Jakalian","year":"2002","journal-title":"J. Comput. Chem."},{"key":"C5OB01604E-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/wcms.1121","volume":"3","author":"Salomon-Ferrer","year":"2013","journal-title":"Wires Comput. Mol. Sci."},{"key":"C5OB01604E-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cpc.2012.09.022","volume":"184","author":"Le Grand","year":"2013","journal-title":"Comput. Phys. Commun."},{"key":"C5OB01604E-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1021\/ja00119a045","volume":"117","author":"Cheatham","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"C5OB01604E-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/jcc.540130805","volume":"13","author":"Miyamoto","year":"1992","journal-title":"J. Comput. Chem."},{"key":"C5OB01604E-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/(SICI)1096-987X(199906)20:8<786::AID-JCC5>3.0.CO;2-B","volume":"20","author":"Feenstra","year":"1999","journal-title":"J. Comput. Chem."},{"key":"C5OB01604E-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","volume":"9","author":"Roe","year":"2013","journal-title":"J. Chem. Theor. Comput."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/OB\/C5OB01604E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:41:39Z","timestamp":1782942099000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/13\/45\/11052-11071\/487606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":57,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c5ob01604e","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C5OB01604E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 31 July 2015; Accepted 10 September 2015; Accepted Manuscript published 10 September 2015; Advance Article published 23 September 2015; Version of Record published 11 November 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}