{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:32:57Z","timestamp":1790055177308,"version":"4.0.1"},"reference-count":76,"publisher":"Royal Society of Chemistry (RSC)","issue":"8","funder":[{"name":"MIT"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<p>New antibiotics are required to treat bacterial infections and counteract the emergence of antibiotic resistance.<\/p>","DOI":"10.1039\/c5sc00962f","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T04:01:11Z","timestamp":1432267271000},"page":"4458-4471","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of \u03b2-lactams for pathogen-selective killing of Escherichia coli"],"prefix":"10.1039","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3325-1899","authenticated-orcid":false,"given":"Phoom","family":"Chairatana","sequence":"first","affiliation":[{"name":"Department of Chemistry"},{"name":"Massachusetts Institute of Technology"},{"name":"Cambridge"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Massachusetts Institute of Technology"},{"name":"Cambridge"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Massachusetts Institute of Technology"},{"name":"Cambridge"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C5SC00962F-(cit1)\/*[position()=1]","volume-title":"Antimicrobial resistance: global report on surveillance 2014","year":"2014","unstructured":"Antimicrobial resistance: global report on surveillance 2014, World Heath Organization, Geneva, 2014"},{"key":"C5SC00962F-(cit2)\/*[position()=1]","volume-title":"Report to the president on combating antibiotic resistance","year":"2014","unstructured":"Report to the president on combating antibiotic resistance, President's Council of Advisors on Science and Technology, 2014"},{"key":"C5SC00962F-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1176667","volume":"325","author":"Fischbach","year":"2009","journal-title":"Science"},{"key":"C5SC00962F-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrd2201","volume":"6","author":"Payne","year":"2007","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C5SC00962F-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nchembio.2007.24","volume":"3","author":"Clatworthy","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"C5SC00962F-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrd3975","volume":"12","author":"Lewis","year":"2013","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C5SC00962F-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.mib.2009.06.012","volume":"12","author":"Barczak","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"key":"C5SC00962F-(cit8)\/*[position()=1]","volume-title":"Antibiotic resistance threats in the United States, 2013","year":"2013","unstructured":"Antibiotic resistance threats in the United States, 2013, U.S. Department of Health and Human Services: Centers for Disease Control and Prevention (CDC), 2013"},{"key":"C5SC00962F-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrmicro1322","volume":"4","author":"Ruiz","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"C5SC00962F-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.chom.2013.04.010","volume":"13","author":"Cassat","year":"2013","journal-title":"Cell Host Microbe"},{"key":"C5SC00962F-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2174\/0929867003375353","volume":"7","author":"Roosenberg II","year":"2000","journal-title":"Curr. Med. Chem."},{"key":"C5SC00962F-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1073\/pnas.0630018100","volume":"100","author":"Raymond","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5SC00962F-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.physiol.69.031905.164337","volume":"69","author":"Andrews","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"C5SC00962F-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/nchembio771","volume":"2","author":"Fischbach","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"C5SC00962F-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1039\/b906679a","volume":"27","author":"Hider","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"C5SC00962F-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1073\/pnas.0737682100","volume":"100","author":"Hantke","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5SC00962F-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0378-1119(96)00560-4","volume":"183","author":"B\u00e4umler","year":"1996","journal-title":"Gene"},{"key":"C5SC00962F-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1128\/JB.180.6.1446-1453.1998","volume":"180","author":"B\u00e4umler","year":"1998","journal-title":"J. Bacteriol."},{"key":"C5SC00962F-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1073\/pnas.0604636103","volume":"103","author":"Fischbach","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5SC00962F-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.chom.2009.03.011","volume":"5","author":"Raffatellu","year":"2009","journal-title":"Cell Host Microbe"},{"key":"C5SC00962F-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1097-2765(02)00708-6","volume":"10","author":"Goetz","year":"2002","journal-title":"Mol. Cell"},{"key":"C5SC00962F-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03104","volume":"432","author":"Flo","year":"2004","journal-title":"Nature"},{"key":"C5SC00962F-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4155\/fmc.11.191","volume":"4","author":"Ji","year":"2012","journal-title":"Future Med. Chem."},{"key":"C5SC00962F-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10534-008-9185-0","volume":"22","author":"Miller","year":"2009","journal-title":"Biometals"},{"key":"C5SC00962F-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1039\/C3MT00359K","volume":"6","author":"Mislin","year":"2014","journal-title":"Metallomics"},{"key":"C5SC00962F-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1568026013395524","volume":"1","author":"Budzikiewicz","year":"2001","journal-title":"Curr. Top. Med. Chem."},{"key":"C5SC00962F-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1054\/drup.1999.0107","volume":"2","author":"Braun","year":"1999","journal-title":"Drug Resist. Updates"},{"key":"C5SC00962F-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"242","DOI":"10.7164\/antibiotics.39.242","volume":"39","author":"Ohi","year":"1986","journal-title":"J. Antibiot."},{"key":"C5SC00962F-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1128\/AAC.34.9.1806","volume":"34","author":"Silley","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"C5SC00962F-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.7164\/antibiotics.43.1617","volume":"43","author":"Hashizume","year":"1990","journal-title":"J. Antibiot."},{"key":"C5SC00962F-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1128\/jb.172.3.1361-1367.1990","volume":"172","author":"Nikaido","year":"1990","journal-title":"J. Bacteriol."},{"key":"C5SC00962F-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/bc00010a013","volume":"2","author":"McKee","year":"1991","journal-title":"Bioconjugate Chem."},{"key":"C5SC00962F-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1128\/AAC.32.12.1879","volume":"32","author":"Curtis","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"C5SC00962F-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1128\/AAC.40.11.2610","volume":"40","author":"Diarra","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"C5SC00962F-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0968-0896(02)00044-5","volume":"10","author":"Wittmann","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"C5SC00962F-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10534-009-9219-2","volume":"22","author":"M\u00f6llmann","year":"2009","journal-title":"Biometals"},{"key":"C5SC00962F-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1039\/c0ob00846j","volume":"9","author":"Yoganathan","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"C5SC00962F-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1021\/ja109665t","volume":"133","author":"Miller","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C5SC00962F-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9898","DOI":"10.1021\/ja303446w","volume":"134","author":"Ji","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"C5SC00962F-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1128\/AAC.00629-13","volume":"57","author":"Tomaras","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"C5SC00962F-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1021\/bc300610f","volume":"24","author":"Wencewicz","year":"2013","journal-title":"Bioconjugate Chem."},{"key":"C5SC00962F-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1021\/jm400265k","volume":"56","author":"Wencewicz","year":"2013","journal-title":"J. Med. Chem."},{"key":"C5SC00962F-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1021\/jm500219c","volume":"57","author":"Starr","year":"2014","journal-title":"J. Med. Chem."},{"key":"C5SC00962F-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9677","DOI":"10.1021\/ja503911p","volume":"136","author":"Zheng","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"C5SC00962F-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18388","DOI":"10.1021\/ja3077268","volume":"143","author":"Zheng","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"C5SC00962F-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1223813","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"C5SC00962F-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrd1157","volume":"2","author":"Nicholson","year":"2003","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C5SC00962F-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s10534-009-9217-4","volume":"22","author":"M\u00fcller","year":"2009","journal-title":"Biometals"},{"key":"C5SC00962F-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tet.2010.11.007","volume":"67","author":"Yu","year":"2011","journal-title":"Tetrahedron"},{"key":"C5SC00962F-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1046\/j.1365-2958.2001.02630.x","volume":"42","author":"Lagos","year":"2001","journal-title":"Mol. Microbiol."},{"key":"C5SC00962F-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1073\/pnas.0408463102","volume":"102","author":"Fischbach","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5SC00962F-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14336","DOI":"10.1021\/ja074650f","volume":"129","author":"Nolan","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"C5SC00962F-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1021\/cb0500034","volume":"1","author":"Luo","year":"2006","journal-title":"ACS Chem. Biol."},{"key":"C5SC00962F-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1021\/ja00514a037","volume":"101","author":"Harris","year":"1979","journal-title":"J. Am. Chem. Soc."},{"key":"C5SC00962F-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1128\/IAI.58.5.1281-1289.1990","volume":"58","author":"Mobley","year":"1990","journal-title":"Infect. Immun."},{"key":"C5SC00962F-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1128\/IAI.69.7.4572-4579.2001","volume":"69","author":"Mulvey","year":"2001","journal-title":"Infect. Immun."},{"key":"C5SC00962F-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17020","DOI":"10.1073\/pnas.252529799","volume":"99","author":"Welch","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5SC00962F-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1000305","DOI":"10.1371\/journal.ppat.1000305","volume":"5","author":"Henderson","year":"2009","journal-title":"PLoS Pathog."},{"key":"C5SC00962F-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1128\/AEM.61.11.4135-4139.1995","volume":"61","author":"Kuhnert","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"C5SC00962F-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jmb.2009.09.022","volume":"394","author":"Daegelen","year":"2009","journal-title":"J. Mol. Biol."},{"key":"C5SC00962F-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s00345-005-0043-1","volume":"24","author":"Reid","year":"2006","journal-title":"World J. Urol."},{"key":"C5SC00962F-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1001\/archinternmed.2012.777","volume":"172","author":"Beerepoot","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"C5SC00962F-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1353\/pbm.1997.0072","volume":"40","author":"Weinberg","year":"1997","journal-title":"Perspect. Biol. Med."},{"key":"C5SC00962F-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e26507","DOI":"10.1371\/journal.pone.0026507","volume":"6","author":"Bailey","year":"2011","journal-title":"PLoS One"},{"key":"C5SC00962F-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e93327","DOI":"10.1371\/journal.pone.0093327","volume":"9","author":"Blango","year":"2014","journal-title":"PLoS One"},{"key":"C5SC00962F-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1152\/physrev.00045.2009","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol. Rev."},{"key":"C5SC00962F-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.2147\/TCRM.S4328","volume":"4","author":"Rafii","year":"2008","journal-title":"Ther. Clin. Risk Manage."},{"key":"C5SC00962F-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0117906","DOI":"10.1371\/journal.pone.0117906","volume":"10","author":"Searle","year":"2015","journal-title":"PLoS One"},{"key":"C5SC00962F-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1128\/JB.01744-06","volume":"189","author":"Lloyd","year":"2007","journal-title":"J. Bacteriol."},{"key":"C5SC00962F-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"184ra60","DOI":"10.1126\/scitranslmed.3005497","volume":"5","author":"Chen","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"C5SC00962F-(cit71)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1039\/c4mt00329b","author":"Subashchandrabose","year":"2015","journal-title":"Metallomics"},{"key":"C5SC00962F-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1128\/JB.181.11.3610-3612.1999","volume":"181","author":"Rabsch","year":"1999","journal-title":"J. Bacteriol."},{"key":"C5SC00962F-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1128\/IAI.01222-10","volume":"79","author":"Garcia","year":"2011","journal-title":"Infect. Immun."},{"key":"C5SC00962F-(cit74)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yexmp.2008.03.007","volume":"85","author":"Wiles","year":"2008","journal-title":"Exp. Mol. Pathol."},{"key":"C5SC00962F-(cit75)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0040-4039(96)02452-5","volume":"38","author":"Ramirez","year":"1997","journal-title":"Tetrahedron Lett."},{"key":"C5SC00962F-(cit76)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1021\/ic00005a007","volume":"30","author":"Scarrow","year":"1991","journal-title":"Inorg. Chem."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/SC\/C5SC00962F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:31:26Z","timestamp":1782851486000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/6\/8\/4458-4471\/502889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":76,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c5sc00962f","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C5SC00962F","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Phoom Chairatana (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-3325-1899","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)","URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 17 March 2015; Accepted 21 May 2015; Accepted Manuscript published 22 May 2015; Advance Article published 10 June 2015; Version of Record published 14 July 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}