{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:04:52Z","timestamp":1782878692997,"version":"3.54.5"},"reference-count":63,"publisher":"Royal Society of Chemistry (RSC)","issue":"8","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["51173216, 31170923 and 31200712"],"award-info":[{"award-number":["51173216, 31170923 and 31200712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<p>\n                    Alendronate-loaded hydroxyapatite-TiO\n                    <sub>2<\/sub>\n                    nanotubes were fabricated for locally improving new bone formation at the bone\u2013implant interface in osteoporotic rabbits.\n                  <\/p>","DOI":"10.1039\/c5tb01956g","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T04:34:21Z","timestamp":1453696461000},"page":"1423-1436","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Alendronate-loaded hydroxyapatite-TiO\n                    <sub>2<\/sub>\n                    nanotubes for improved bone formation in osteoporotic rabbits"],"prefix":"10.1039","volume":"4","author":[{"given":"Xinkun","family":"Shen","sequence":"first","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoqiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichun","family":"Ran","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglin","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Mu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyong","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology"},{"name":"Ministry of Education, College of Bioengineering"},{"name":"Chongqing University"},{"name":"Chongqing 400044"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C5TB01956G-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.jmbbm.2011.05.011","volume":"4","author":"Chang","year":"2011","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"C5TB01956G-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9747","DOI":"10.1016\/j.biomaterials.2014.08.007","volume":"35","author":"Park","year":"2014","journal-title":"Biomaterials"},{"key":"C5TB01956G-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/978-1-4939-0956-8_17","volume":"1175","author":"Riancho","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"C5TB01956G-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1210\/en.2004-0735","volume":"146","author":"Ali","year":"2005","journal-title":"Endocrinology"},{"key":"C5TB01956G-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","volume":"22","author":"Burge","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"C5TB01956G-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biomaterials.2015.06.025","volume":"63","author":"Agarwal","year":"2015","journal-title":"Biomaterials"},{"key":"C5TB01956G-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/145749690609500205","volume":"95","author":"Moroni","year":"2006","journal-title":"Scand. J. Surg."},{"key":"C5TB01956G-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17323","DOI":"10.1021\/am5045604","volume":"6","author":"Zhang","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C5TB01956G-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1039\/C4TB00666F","volume":"2","author":"Li","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"C5TB01956G-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1016\/j.jprot.2012.03.033","volume":"75","author":"Zhao","year":"2012","journal-title":"J. Proteomics"},{"key":"C5TB01956G-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1039\/C4TB01498G","volume":"3","author":"Xie","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"C5TB01956G-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16426","DOI":"10.1021\/am5049338","volume":"6","author":"Shen","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C5TB01956G-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"963","DOI":"10.11607\/jomi.2421","volume":"28","author":"Ryu","year":"2013","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"C5TB01956G-(cit14)\/*[position()=1]","first-page":"859","volume":"7","author":"Yamada","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"C5TB01956G-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/jbm.b.10057","volume":"67","author":"Barr\u00e8re","year":"2003","journal-title":"J. Biomed. Mater. Res., Part B"},{"key":"C5TB01956G-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/00003086-199203000-00014","volume":"276","author":"Ducheyne","year":"1992","journal-title":"Clin. Orthop. Relat. Res."},{"key":"C5TB01956G-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.apsusc.2014.04.207","volume":"311","author":"Parcharoen","year":"2014","journal-title":"Appl. Surf. Sci."},{"key":"C5TB01956G-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"B216","DOI":"10.1002\/adem.201180073","volume":"5","author":"Chen","year":"2012","journal-title":"Adv. Eng. Mater."},{"key":"C5TB01956G-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.biomaterials.2014.11.002","volume":"39","author":"Lv","year":"2015","journal-title":"Biomaterials"},{"key":"C5TB01956G-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.actbio.2009.02.032","volume":"5","author":"Kodama","year":"2009","journal-title":"Acta Biomater."},{"key":"C5TB01956G-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.3760\/cma.j.issn.0366-6999.20141670","volume":"127","author":"Zhao","year":"2014","journal-title":"Chin. Med. J."},{"key":"C5TB01956G-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jconrel.2010.06.016","volume":"147","author":"Kim","year":"2010","journal-title":"J. Controlled Release"},{"key":"C5TB01956G-(cit23)\/*[position()=1]","first-page":"187","volume":"40","author":"Vinicola","year":"2015","journal-title":"Minerva Endocrinol."},{"key":"C5TB01956G-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1530\/JOE-13-0040","volume":"219","author":"Komatsu","year":"2013","journal-title":"J. Endocrinol."},{"key":"C5TB01956G-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.joen.2014.07.010","volume":"41","author":"Martins","year":"2015","journal-title":"J. Endod."},{"key":"C5TB01956G-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S8756-3282(97)00270-6","volume":"22","author":"Garc\u00eda-Moreno","year":"1998","journal-title":"Bone"},{"key":"C5TB01956G-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1083\/jcb.102.4.1164","volume":"102","author":"Blair","year":"1986","journal-title":"J. Cell Biol."},{"key":"C5TB01956G-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature10763","volume":"481","author":"Karsenty","year":"2012","journal-title":"Nature"},{"key":"C5TB01956G-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0142-9612(01)00179-X","volume":"23","author":"Hankermeyer","year":"2002","journal-title":"Biomaterials"},{"key":"C5TB01956G-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"045012","DOI":"10.1088\/1748-6041\/7\/4\/045012","volume":"7","author":"Long","year":"2012","journal-title":"Biomed. Mater."},{"key":"C5TB01956G-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"m543","DOI":"10.1107\/S0108270103025599","volume":"59","author":"Fern\u00e1ndez","year":"2003","journal-title":"Acta Crystallogr., Sect. C: Cryst. Struct. Commun."},{"key":"C5TB01956G-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molstruc.2006.04.032","volume":"825","author":"Robinson","year":"2006","journal-title":"J. Mol. Struct."},{"key":"C5TB01956G-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.scitotenv.2012.08.045","volume":"438","author":"Peng","year":"2012","journal-title":"Sci. Total Environ."},{"key":"C5TB01956G-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jchromb.2006.02.027","volume":"834","author":"Tatar Ulu","year":"2006","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"C5TB01956G-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.colsurfb.2015.01.048","volume":"127","author":"Shen","year":"2015","journal-title":"Colloids Surf., B"},{"key":"C5TB01956G-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"274","DOI":"10.5468\/kjog.2010.53.3.274","volume":"53","author":"Park","year":"2010","journal-title":"Korean J. Obstet. Gynecol."},{"key":"C5TB01956G-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/ahg.12118","volume":"79","author":"Priyadarshi","year":"2015","journal-title":"Ann. Hum. Genet."},{"key":"C5TB01956G-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1096\/fj.11-194399","volume":"26","author":"Hwang","year":"2012","journal-title":"FASEB J."},{"key":"C5TB01956G-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13053","DOI":"10.1021\/acsami.5b03209","volume":"7","author":"Cheng","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C5TB01956G-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10908","DOI":"10.1166\/jnn.2011.3941","volume":"11","author":"Zhang","year":"2011","journal-title":"J. Nanosci. Nanotechnol."},{"key":"C5TB01956G-(cit41)\/*[position()=1]","first-page":"499","volume":"19","author":"Cai","year":"2008","journal-title":"J. Mater. Sci.: Mater. Med."},{"key":"C5TB01956G-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.msec.2014.10.046","volume":"46","author":"Boyd","year":"2015","journal-title":"Mater. Sci. Eng., C"},{"key":"C5TB01956G-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4047\/jap.2013.5.4.402","volume":"5","author":"Park","year":"2013","journal-title":"J. Adv. Prosthodont."},{"key":"C5TB01956G-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1101\/gad.213827.113","volume":"27","author":"Ferron","year":"2013","journal-title":"Genes Dev."},{"key":"C5TB01956G-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1039\/C4TB00597J","volume":"2","author":"Hao","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"C5TB01956G-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1021\/am4046316","volume":"6","author":"Collart-Dutilleul","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C5TB01956G-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.2147\/IJN.S56661","volume":"9","author":"Filov\u00e1","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"C5TB01956G-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10971-011-2601-x","volume":"61","author":"Dou","year":"2012","journal-title":"J. Sol-Gel Sci. Technol."},{"key":"C5TB01956G-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1016\/j.actbio.2012.07.002","volume":"8","author":"Chai","year":"2012","journal-title":"Acta Biomater."},{"key":"C5TB01956G-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1016\/j.actbio.2014.05.033","volume":"10","author":"Yang","year":"2014","journal-title":"Acta Biomater."},{"key":"C5TB01956G-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1016\/j.biomaterials.2012.01.040","volume":"33","author":"Hu","year":"2012","journal-title":"Biomaterials"},{"key":"C5TB01956G-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jbm.a.31618","volume":"86","author":"Park","year":"2008","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"C5TB01956G-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.actbio.2015.03.018","volume":"19","author":"Jiang","year":"2015","journal-title":"Acta Biomater."},{"key":"C5TB01956G-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jiec.2015.01.019","volume":"27","author":"Yang","year":"2015","journal-title":"J. Ind. Eng. Chem."},{"key":"C5TB01956G-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1163\/156856202753419240","volume":"12","author":"Cai","year":"2001","journal-title":"J. Biomater. Sci., Polym. Ed."},{"key":"C5TB01956G-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s10354-010-0818-x","volume":"160","author":"Wagner","year":"2010","journal-title":"Wien. Med. Wochenschr."},{"key":"C5TB01956G-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3109\/08941939.2014.916369","volume":"27","author":"Mizrak","year":"2014","journal-title":"J. Invest. Surg."},{"key":"C5TB01956G-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s00198-009-1129-1","volume":"21","author":"D\u2019Amelio","year":"2010","journal-title":"Osteoporosis Int."},{"key":"C5TB01956G-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00784-011-0614-z","volume":"16","author":"Ohe","year":"2012","journal-title":"Clin. Oral Investig."},{"key":"C5TB01956G-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jsbmb.2015.04.003","volume":"152","author":"Gu","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"C5TB01956G-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jmbbm.2014.04.007","volume":"36","author":"RakngarmNimkerdphol","year":"2014","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"C5TB01956G-(cit62)\/*[position()=1]","first-page":"548","volume":"7","author":"Chen","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"C5TB01956G-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.msec.2008.07.038","volume":"29","author":"Nejati","year":"2009","journal-title":"Mater. Sci. Eng., C"}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/TB\/C5TB01956G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:24:41Z","timestamp":1782876281000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/tb\/article\/4\/8\/1423-1436\/508306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":63,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c5tb01956g","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 21 September 2015; Accepted 21 January 2016; Accepted Manuscript published 25 January 2016; Advance Article published 1 February 2016; Version of Record published 17 February 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}