{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:32:12Z","timestamp":1781069532455,"version":"3.54.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81172527"],"award-info":[{"award-number":["81172527"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81472800"],"award-info":[{"award-number":["81472800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Toxicol. Res."],"abstract":"<p>Valproic acid (VPA) is one of the representative compounds of histone deacetylase inhibitors (HDACis) and is used widely for the clinical treatment of epilepsy and other convulsive diseases.<\/p>","DOI":"10.1039\/c5tx00476d","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T12:04:15Z","timestamp":1455797055000},"page":"859-870","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Valproic acid causes radiosensitivity of breast cancer cells via disrupting the DNA repair pathway"],"prefix":"10.1093","volume":"5","author":[{"given":"Yue","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine"},{"name":"The Public Health School"},{"name":"Shandong University"},{"name":"Shandong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine"},{"name":"The Public Health School"},{"name":"Shandong University"},{"name":"Shandong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xipeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine"},{"name":"The Public Health School"},{"name":"Shandong University"},{"name":"Shandong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine"},{"name":"The Public Health School"},{"name":"Shandong University"},{"name":"Shandong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine"},{"name":"The Public Health School"},{"name":"Shandong University"},{"name":"Shandong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Guo","sequence":"additional","affiliation":[{"name":"Image Center"},{"name":"Jinan Third People's Hospital"},{"name":"Shandong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongshe","family":"Guo","sequence":"additional","affiliation":[{"name":"The Second Hospital of Shandong University"},{"name":"Shandong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology"},{"name":"Washington University School of Medicine"},{"name":"St. Louis"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon N.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Molecular Biology Program"},{"name":"Memorial Sloan Kettering Cancer Center"},{"name":"New York"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Occupational Medicine"},{"name":"The Public Health School"},{"name":"Shandong University"},{"name":"Shandong"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C5TX00476D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/bjc.2013.21","volume":"108","author":"Groselj","year":"2013","journal-title":"Br. J. Cancer"},{"key":"C5TX00476D-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/jcb.22185","volume":"107","author":"Marks","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"C5TX00476D-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.bbagrm.2010.05.008","volume":"1799","author":"Marks","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"C5TX00476D-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s13277-013-1134-z","volume":"35","author":"He","year":"2014","journal-title":"Tumour Biol."},{"key":"C5TX00476D-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1464-410X.2012.11647.x","volume":"111","author":"Sharma","year":"2013","journal-title":"BJU Int."},{"key":"C5TX00476D-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ijrobp.2010.03.010","volume":"78","author":"Blattmann","year":"2010","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"C5TX00476D-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/ncponc0106","volume":"2","author":"Kelly","year":"2005","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"C5TX00476D-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1158\/1541-7786.MCR-07-0324","volume":"5","author":"Dokmanovic","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"C5TX00476D-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4161\/epi.1.3.2896","volume":"1","author":"Karagiannis","year":"2006","journal-title":"Epigenetics"},{"key":"C5TX00476D-(cit10)\/*[position()=1]","first-page":"787","volume":"37","author":"Kawano","year":"2010","journal-title":"Int. J. Oncol."},{"key":"C5TX00476D-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/cncr.22891","volume":"110","author":"Kuendgen","year":"2007","journal-title":"Cancer"},{"key":"C5TX00476D-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ctrv.2007.11.003","volume":"34","author":"Duenas-Gonzalez","year":"2008","journal-title":"Cancer Treat. Rev."},{"key":"C5TX00476D-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14639","DOI":"10.1073\/pnas.1008522107","volume":"107","author":"Lee","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5TX00476D-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"468","DOI":"10.4161\/cc.7.4.5405","volume":"7","author":"Harikrishnan","year":"2008","journal-title":"Cell Cycle"},{"key":"C5TX00476D-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/bdrb.20236","volume":"89","author":"Sha","year":"2010","journal-title":"Birth Defects Res., Part B"},{"key":"C5TX00476D-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"823","DOI":"10.4161\/cbt.8.9.8143","volume":"8","author":"Zhang","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"C5TX00476D-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.4155\/fmc.12.80","volume":"4","author":"Giannini","year":"2012","journal-title":"Future Med. Chem."},{"key":"C5TX00476D-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.canlet.2014.09.049","volume":"356","author":"Pont","year":"2015","journal-title":"Cancer Lett."},{"key":"C5TX00476D-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.dnarep.2011.07.003","volume":"10","author":"Koprinarova","year":"2011","journal-title":"DNA Repair"},{"key":"C5TX00476D-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1093\/nar\/gks270","volume":"40","author":"Krejci","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"C5TX00476D-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.molcel.2012.07.029","volume":"47","author":"Chapman","year":"2012","journal-title":"Mol. Cell."},{"key":"C5TX00476D-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nrm2851","volume":"11","author":"Moynahan","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C5TX00476D-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e87203","DOI":"10.1371\/journal.pone.0087203","volume":"9","author":"Smith","year":"2014","journal-title":"PLoS One"},{"key":"C5TX00476D-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijrobp.2004.12.088","volume":"62","author":"Chinnaiyan","year":"2005","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"C5TX00476D-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1093\/nar\/gkn550","volume":"36","author":"Kinner","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"C5TX00476D-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.146.5.905","volume":"146","author":"Rogakou","year":"1999","journal-title":"J. Cell Biol."},{"key":"C5TX00476D-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","volume":"273","author":"Rogakou","year":"1998","journal-title":"J. Biol. Chem."},{"key":"C5TX00476D-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1667\/RR2323.1","volume":"175","author":"Chen","year":"2011","journal-title":"Radiat. Res."},{"key":"C5TX00476D-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.dnarep.2010.09.013","volume":"9","author":"Goodarzi","year":"2010","journal-title":"DNA Repair"},{"key":"C5TX00476D-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000077461","volume":"104","author":"Iliakis","year":"2004","journal-title":"Cytogenet. Genome Res."},{"key":"C5TX00476D-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1080\/15384101.2015.1049784","volume":"14","author":"Kostyrko","year":"2015","journal-title":"Cell Cycle"},{"key":"C5TX00476D-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3389\/fonc.2014.00289","volume":"4","author":"Alagpulinsa","year":"2014","journal-title":"Front. Oncol."},{"key":"C5TX00476D-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1158\/1541-7786.MCR-05-0192","volume":"3","author":"Zhang","year":"2005","journal-title":"Mol. Cancer Res."},{"key":"C5TX00476D-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10549-015-3459-3","volume":"152","author":"Vaclova","year":"2015","journal-title":"Breast Cancer Res. Treat."},{"key":"C5TX00476D-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1667\/RR3034.1","volume":"179","author":"Wu","year":"2013","journal-title":"Radiat. Res."},{"key":"C5TX00476D-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/978-1-61779-998-3_27","volume":"920","author":"Gunn","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"C5TX00476D-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7065","DOI":"10.1158\/0008-5472.CAN-04-1082","volume":"64","author":"Essmann","year":"2004","journal-title":"Cancer Res."},{"key":"C5TX00476D-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1089\/cbr.2009.0629","volume":"24","author":"Chen","year":"2009","journal-title":"Cancer Biother. Radiopharm."},{"key":"C5TX00476D-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ygyno.2014.03.007","volume":"133","author":"Konstantinopoulos","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"C5TX00476D-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19482","DOI":"10.1073\/pnas.0707828104","volume":"104","author":"Adimoolam","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5TX00476D-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e11208","DOI":"10.1371\/journal.pone.0011208","volume":"5","author":"Kachhap","year":"2010","journal-title":"PLoS One"},{"key":"C5TX00476D-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ijrobp.2015.04.038","volume":"92","author":"Krauze","year":"2015","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"C5TX00476D-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.dnarep.2015.06.005","volume":"33","author":"Dong","year":"2015","journal-title":"DNA Repair"}],"container-title":["Toxicology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/TX\/C5TX00476D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T12:18:56Z","timestamp":1748780336000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxres\/article\/5\/3\/859-870\/5568588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c5tx00476d","relation":{},"ISSN":["2045-452X","2045-4538"],"issn-type":[{"value":"2045-452X","type":"print"},{"value":"2045-4538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 18 December 2015; Accepted 16 February 2016; Accepted Manuscript published 18 February 2016; Advance Article published 2 March 2016; Version of Record published 3 May 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}