{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:39:48Z","timestamp":1783539588207,"version":"3.55.0"},"reference-count":36,"publisher":"Royal Society of Chemistry (RSC)","issue":"84","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01AI119564"],"award-info":[{"award-number":["R01AI119564"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R21AI117878"],"award-info":[{"award-number":["R21AI117878"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<p>A series of novel substituted picolinic acids demonstrated low micromolar inhibition of botulinum neurotoxin A light chain at the \u03b2-exosite.<\/p>","DOI":"10.1039\/c6cc06749b","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T11:31:25Z","timestamp":1475235085000},"page":"12521-12524","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Picolinic acids as \u03b2-exosite inhibitors of botulinum neurotoxin A light chain"],"prefix":"10.1039","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-1743","authenticated-orcid":false,"given":"Paul T.","family":"Bremer","sequence":"first","affiliation":[{"name":"Departments of Chemistry, Immunology and Microbial Sciences"},{"name":"Worm Institute for Research and Medicine (WIRM)"},{"name":"The Scripps Research Institute"},{"name":"La Jolla"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xue","sequence":"additional","affiliation":[{"name":"Departments of Chemistry, Immunology and Microbial Sciences"},{"name":"Worm Institute for Research and Medicine (WIRM)"},{"name":"The Scripps Research Institute"},{"name":"La Jolla"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim D.","family":"Janda","sequence":"additional","affiliation":[{"name":"Departments of Chemistry, Immunology and Microbial Sciences"},{"name":"Worm Institute for Research and Medicine (WIRM)"},{"name":"The Scripps Research Institute"},{"name":"La Jolla"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6CC06749B-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/jama.285.8.1059","volume":"285","author":"Arnon","year":"2001","journal-title":"J. Am. Med. Assoc."},{"key":"C6CC06749B-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/infdis\/166.6.1281","volume":"166","author":"Woodruff","year":"1992","journal-title":"J. Infect. Dis."},{"key":"C6CC06749B-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.4315\/0362-028X.JFP-11-128","volume":"74","author":"Date","year":"2011","journal-title":"J. Food Prot."},{"key":"C6CC06749B-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1126\/science.283.5406.1279","volume":"283","author":"Henderson","year":"1999","journal-title":"Science"},{"key":"C6CC06749B-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1001\/jama.1997.03550050095041","volume":"278","author":"Shapiro","year":"1997","journal-title":"J. Am. Med. Assoc."},{"key":"C6CC06749B-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/0002-9343(84)90988-4","volume":"76","author":"Tacket","year":"1984","journal-title":"Am. J. Med."},{"key":"C6CC06749B-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/MMBR.56.1.80-99.1992","volume":"56","author":"Schantz","year":"1992","journal-title":"Microbiol. Rev."},{"key":"C6CC06749B-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/jnnp.2003.034702","volume":"75","author":"Jankovic","year":"2004","journal-title":"J. Neurol., Neurosurg. Psychiatry"},{"key":"C6CC06749B-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0022-3565(25)21077-1","volume":"251","author":"Simpson","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"C6CC06749B-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/365160a0","volume":"365","author":"Blasi","year":"1993","journal-title":"Nature"},{"key":"C6CC06749B-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1113\/jphysiol.1949.sp004364","volume":"109","author":"Burgen","year":"1949","journal-title":"J. Physiol."},{"key":"C6CC06749B-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1021\/ol0603211","volume":"8","author":"Boldt","year":"2006","journal-title":"Org. Lett."},{"key":"C6CC06749B-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18883","DOI":"10.1074\/jbc.M801240200","volume":"283","author":"Kumaran","year":"2008","journal-title":"J. Biol. Chem."},{"key":"C6CC06749B-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.bmc.2012.12.001","volume":"21","author":"Silhar","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"C6CC06749B-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.chembiol.2007.03.014","volume":"14","author":"Silvaggi","year":"2007","journal-title":"Chem. Biol."},{"key":"C6CC06749B-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1021\/jm4012164","volume":"57","author":"Caglic","year":"2014","journal-title":"J. Med. Chem."},{"key":"C6CC06749B-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1128\/AAC.00141-09","volume":"53","author":"Roxas-Duncan","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"C6CC06749B-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0135306","DOI":"10.1371\/journal.pone.0135306","volume":"10","author":"Fan","year":"2015","journal-title":"PLoS One"},{"key":"C6CC06749B-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jmb.2010.01.070","volume":"397","author":"Dong","year":"2010","journal-title":"J. Mol. Biol."},{"key":"C6CC06749B-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1021\/ml100074s","volume":"1","author":"Eubanks","year":"2010","journal-title":"ACS Med. Chem. Lett."},{"key":"C6CC06749B-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1021\/ja910761y","volume":"132","author":"Silhar","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"C6CC06749B-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1753-4887.1980.tb05874.x","volume":"38","author":"Evans","year":"1980","journal-title":"Nutr. Rev."},{"key":"C6CC06749B-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.bmc.2016.01.001","volume":"24","author":"Zhu","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"C6CC06749B-(cit24)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1039\/b808305c","author":"Capkova","year":"2008","journal-title":"Chem. Commun."},{"key":"C6CC06749B-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1021\/ol301570t","volume":"14","author":"Robbins","year":"2012","journal-title":"Org. Lett."},{"key":"C6CC06749B-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1021\/ja994479a","volume":"122","author":"Moran","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"C6CC06749B-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/0003-9861(64)90185-7","volume":"106","author":"Theorell","year":"1964","journal-title":"Arch. Biochem. Biophys."},{"key":"C6CC06749B-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1039\/C5CC00677E","volume":"51","author":"Seki","year":"2015","journal-title":"Chem. Commun."},{"key":"C6CC06749B-(cit29)\/*[position()=1]","unstructured":"OMEGA version 2.4.6. OpenEye Scientific Software, Santa Fe, NM, http:\/\/www.eyesopen.com"},{"key":"C6CC06749B-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1021\/ci300314k","volume":"52","author":"Hawkins","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"C6CC06749B-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1021\/ci100031x","volume":"50","author":"Hawkins","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"C6CC06749B-(cit32)\/*[position()=1]","unstructured":"FRED version 2.2.5. OpenEye Scientific Software, Santa Fe, NM, http:\/\/www.eyesopen.com"},{"key":"C6CC06749B-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1021\/ci100436p","volume":"51","author":"McGann","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"C6CC06749B-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10822-012-9584-8","volume":"26","author":"McGann","year":"2012","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"C6CC06749B-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/nature03123","volume":"432","author":"Breidenbach","year":"2004","journal-title":"Nature"},{"key":"C6CC06749B-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s10822-014-9758-7","volume":"28","author":"Hu","year":"2014","journal-title":"J. Comput.-Aided Mol. Des."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/CC\/C6CC06749B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:04:51Z","timestamp":1783533891000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/52\/84\/12521-12524\/514017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":36,"journal-issue":{"issue":"84","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6cc06749b","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C6CC06749B","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Paul T. Bremer (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8357-1743","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 17 August 2016; Accepted 28 September 2016; Accepted Manuscript published 30 September 2016; Advance Article published 6 October 2016; Version of Record published 13 October 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}