{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:02:45Z","timestamp":1788498165087,"version":"build-2803163510"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Phys. Chem. Chem. Phys."],"abstract":"<p>Removal of the Cys2\u2013Cys7 disulfide bonds in amylin oligomers decreases polymorphism and induces cross-\u03b2 structures in the N-termini.<\/p>","DOI":"10.1039\/c6cp01196a","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T06:04:12Z","timestamp":1460527452000},"page":"12438-12442","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The removal of disulfide bonds in amylin oligomers leads to the conformational change of the \u2018native\u2019 amylin oligomers"],"prefix":"10.1039","volume":"18","author":[{"given":"Vered","family":"Wineman-Fisher","sequence":"first","affiliation":[{"name":"Department of Chemistry"},{"name":"Ben-Gurion University of the Negev"},{"name":"Be\u00e9r Sheva 84105"},{"name":"Israel"},{"name":"Ilse Katz Institute for Nanoscale Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Tudorachi","sequence":"additional","affiliation":[{"name":"Al. I. Cuza University of Iasi"},{"name":"Iasi-700506"},{"name":"Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einav","family":"Nissim","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Ben-Gurion University of the Negev"},{"name":"Be\u00e9r Sheva 84105"},{"name":"Israel"},{"name":"Ilse Katz Institute for Nanoscale Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifat","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Ben-Gurion University of the Negev"},{"name":"Be\u00e9r Sheva 84105"},{"name":"Israel"},{"name":"Ilse Katz Institute for Nanoscale Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6CP01196A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biocel.2005.12.009","volume":"38","author":"Hoppener","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"C6CP01196A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-5793(00)01287-4","volume":"470","author":"Higham","year":"2000","journal-title":"FEBS Lett."},{"key":"C6CP01196A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1006\/jmbi.1999.2646","volume":"287","author":"Kayed","year":"1999","journal-title":"J. Mol. Biol."},{"key":"C6CP01196A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0140-6736(87)90825-7","volume":"2","author":"Clark","year":"1987","journal-title":"Lancet"},{"key":"C6CP01196A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7048","DOI":"10.1002\/anie.201100986","volume":"50","author":"Mossuto","year":"2011","journal-title":"Angew. Chem."},{"key":"C6CP01196A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/prot.24338","volume":"81","author":"Li","year":"2013","journal-title":"Proteins"},{"key":"C6CP01196A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jmb.2006.05.007","volume":"360","author":"Devlin","year":"2006","journal-title":"J. Mol. Biol."},{"key":"C6CP01196A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s00249-010-0576-0","volume":"39","author":"Wang","year":"2010","journal-title":"Eur. Biophys. J."},{"key":"C6CP01196A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.bbapap.2007.08.016","volume":"1774","author":"Maeda","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"C6CP01196A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.biochi.2011.02.006","volume":"93","author":"Sarkar","year":"2011","journal-title":"Biochimie"},{"key":"C6CP01196A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"614","DOI":"10.2174\/138920309789630534","volume":"10","author":"Trivedi","year":"2009","journal-title":"Curr. Protein Pept. Sci."},{"key":"C6CP01196A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0968-0004(99)01445-0","volume":"24","author":"Dobson","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"C6CP01196A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0959-440X(98)80016-X","volume":"8","author":"Kelly","year":"1998","journal-title":"Curr. Opin. Struct. Biol."},{"key":"C6CP01196A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0959-440X(99)00049-4","volume":"10","author":"Rochet","year":"2000","journal-title":"Curr. Opin. Struct. Biol."},{"key":"C6CP01196A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0969-2126(00)00065-4","volume":"2","author":"Harpaz","year":"1994","journal-title":"Structure"},{"key":"C6CP01196A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1021\/bi992922o","volume":"39","author":"Wedemeyer","year":"2000","journal-title":"Biochemistry"},{"key":"C6CP01196A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399407000385","volume":"9","author":"Rochet","year":"2007","journal-title":"Expert Rev. Mol. Med."},{"key":"C6CP01196A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11263","DOI":"10.1073\/pnas.0704307104","volume":"104","author":"Banci","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6CP01196A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10278","DOI":"10.1021\/bi060879g","volume":"45","author":"Huang","year":"2006","journal-title":"Biochemistry"},{"key":"C6CP01196A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23459","DOI":"10.1074\/jbc.M110336200","volume":"277","author":"Dangoria","year":"2002","journal-title":"J. Biol. Chem."},{"key":"C6CP01196A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"28087","DOI":"10.1074\/jbc.M704465200","volume":"282","author":"Niwa","year":"2007","journal-title":"J. Biol. Chem."},{"key":"C6CP01196A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmb.2005.02.029","volume":"348","author":"Kajava","year":"2005","journal-title":"J. Mol. Biol."},{"key":"C6CP01196A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13505","DOI":"10.1021\/bi701427q","volume":"46","author":"Luca","year":"2007","journal-title":"Biochemistry"},{"key":"C6CP01196A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jmb.2008.05.013","volume":"380","author":"Tartaglia","year":"2008","journal-title":"J. Mol. Biol."},{"key":"C6CP01196A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1006\/jsbi.2000.4268","volume":"130","author":"Goldsbury","year":"2000","journal-title":"J. Struct. Biol."},{"key":"C6CP01196A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1110\/ps.041051205","volume":"14","author":"Koo","year":"2005","journal-title":"Protein Sci."},{"key":"C6CP01196A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1021\/jp100205w","volume":"114","author":"Laghaei","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"C6CP01196A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1021\/bi800828u","volume":"47","author":"Yonemoto","year":"2008","journal-title":"Biochemistry"},{"key":"C6CP01196A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1016\/j.bpj.2009.08.041","volume":"97","author":"Vaiana","year":"2009","journal-title":"Biophys. J."},{"key":"C6CP01196A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1021\/bm501326y","volume":"16","author":"Wineman-Fisher","year":"2015","journal-title":"Biomacromolecules"},{"key":"C6CP01196A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1110\/ps.036509.108","volume":"17","author":"Wiltzius","year":"2008","journal-title":"Protein Sci."},{"key":"C6CP01196A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/jcph.1999.6201","volume":"151","author":"Kale","year":"1999","journal-title":"J. Comput. Phys."},{"key":"C6CP01196A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"Brooks","year":"1983","journal-title":"J. Comput. Chem."},{"key":"C6CP01196A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1021\/jp973084f","volume":"102","author":"MacKerell","year":"1998","journal-title":"J. Phys. Chem. B"},{"key":"C6CP01196A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1002\/jcc.10367","volume":"24","author":"Lee","year":"2003","journal-title":"J. Comput. Chem."},{"key":"C6CP01196A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10606","DOI":"10.1063\/1.1480013","volume":"116","author":"Lee","year":"2002","journal-title":"J. Chem. Phys."},{"key":"C6CP01196A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1021\/ar2000869","volume":"45","author":"Thirumalai","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"C6CP01196A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11066","DOI":"10.1021\/ja8017303","volume":"130","author":"Krone","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"C6CP01196A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21459","DOI":"10.1073\/pnas.1008616107","volume":"107","author":"Reddy","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6CP01196A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1021\/bi200400u","volume":"50","author":"Miller","year":"2011","journal-title":"Biochemistry"},{"key":"C6CP01196A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1039\/c3cp54890b","volume":"16","author":"Raz","year":"2014","journal-title":"Phys. Chem. Chem. Phys."},{"key":"C6CP01196A-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e73303","DOI":"10.1371\/journal.pone.0073303","volume":"8","author":"Raz","year":"2013","journal-title":"PLoS One"},{"key":"C6CP01196A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/jcc.10272","volume":"24","author":"Lee","year":"2003","journal-title":"J. Comput. Chem."},{"key":"C6CP01196A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10606","DOI":"10.1063\/1.1480013","volume":"116","author":"Lee","year":"2002","journal-title":"J. Chem. Phys."}],"container-title":["Physical Chemistry Chemical Physics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/CP\/C6CP01196A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:01:44Z","timestamp":1782878504000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cp\/article\/18\/18\/12438-12442\/517021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":44,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6cp01196a","relation":{},"ISSN":["1463-9076","1463-9084"],"issn-type":[{"value":"1463-9076","type":"print"},{"value":"1463-9084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C6CP01196A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The PCCP Owner Societies have an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)","URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 22 February 2016; Accepted 8 April 2016;  Accepted Manuscript published 13 April 2016;  Advance Article published 25 April 2016;  Version of Record published 4 May 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}