{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:02:45Z","timestamp":1788498165084,"version":"build-2803163510"},"reference-count":64,"publisher":"Royal Society of Chemistry (RSC)","issue":"31","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Phys. Chem. Chem. Phys."],"abstract":"<p>\n                    High and low concentrations of Zn\n                    <sup>2+<\/sup>\n                    ions decrease the polymorphism of amylin oligomers and do not affect their cross \u03b2-beta structures.\n                  <\/p>","DOI":"10.1039\/c6cp04105a","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T07:03:16Z","timestamp":1467788596000},"page":"21590-21599","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Zn\n                    <sup>2+<\/sup>\n                    ions on the assembly of amylin oligomers: insight into the molecular mechanisms"],"prefix":"10.1039","volume":"18","author":[{"given":"Vered","family":"Wineman-Fisher","sequence":"first","affiliation":[{"name":"Department of Chemistry"},{"name":"Ben-Gurion University of the Negev"},{"name":"Be'er Sheva 84105"},{"name":"Israel"},{"name":"Ilse Katz Institute for Nanoscale Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifat","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Ben-Gurion University of the Negev"},{"name":"Be'er Sheva 84105"},{"name":"Israel"},{"name":"Ilse Katz Institute for Nanoscale Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6CP04105A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.1016\/j.biomaterials.2011.05.021","volume":"32","author":"Bongiovanni","year":"2011","journal-title":"Biomaterials"},{"key":"C6CP04105A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.1093783","volume":"303","author":"Silva","year":"2004","journal-title":"Science"},{"key":"C6CP04105A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nnano.2012.62","volume":"7","author":"Li","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"C6CP04105A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1021\/bm401646x","volume":"15","author":"Reynolds","year":"2014","journal-title":"Biomacromolecules"},{"key":"C6CP04105A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1021\/bm400430t","volume":"14","author":"Reynolds","year":"2013","journal-title":"Biomacromolecules"},{"key":"C6CP04105A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9758","DOI":"10.1073\/pnas.1218402110","volume":"110","author":"Cohen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6CP04105A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.1021\/nn401988m","volume":"7","author":"Bolisetty","year":"2013","journal-title":"ACS Nano"},{"key":"C6CP04105A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nnano.2011.102","volume":"6","author":"Knowles","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"C6CP04105A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nnano.2014.199","volume":"9","author":"Zhong","year":"2014","journal-title":"Nat. Nanotechnol."},{"key":"C6CP04105A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6654","DOI":"10.1073\/pnas.1322602111","volume":"111","author":"Ikenoue","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6CP04105A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/j.ccr.2012.04.004","volume":"256","author":"Leal","year":"2012","journal-title":"Coord. Chem. Rev."},{"key":"C6CP04105A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-2236(03)00067-5","volume":"26","author":"Bush","year":"2003","journal-title":"Trends Neurosci."},{"key":"C6CP04105A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/fcp.12110","volume":"29","author":"Prakash","year":"2015","journal-title":"Fundam. Clin. Pharmacol."},{"key":"C6CP04105A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1021\/bi101912q","volume":"50","author":"Dudzik","year":"2011","journal-title":"Biochemistry"},{"key":"C6CP04105A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12017-009-8082-1","volume":"11","author":"Bisaglia","year":"2009","journal-title":"NeuroMol. Med."},{"key":"C6CP04105A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s00249-011-0713-4","volume":"40","author":"Stellato","year":"2011","journal-title":"Eur. Biophys. J."},{"key":"C6CP04105A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jinorgbio.2012.06.011","volume":"117","author":"Valiente-Gabioud","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"C6CP04105A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1021\/ja045958z","volume":"127","author":"Gaggelli","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"C6CP04105A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15440","DOI":"10.1021\/ja077146j","volume":"129","author":"Walter","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"C6CP04105A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1039\/b401985g","author":"Brown","year":"2004","journal-title":"Dalton Trans."},{"key":"C6CP04105A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1021\/bi702423h","volume":"47","author":"Karr","year":"2008","journal-title":"Biochemistry"},{"key":"C6CP04105A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1021\/ja1072178","volume":"133","author":"Parthasarathy","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C6CP04105A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1021\/ja903669a","volume":"131","author":"Drew","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"C6CP04105A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.biochi.2009.03.013","volume":"91","author":"Hureau","year":"2009","journal-title":"Biochimie"},{"key":"C6CP04105A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9490","DOI":"10.1073\/pnas.0913114107","volume":"107","author":"Miller","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6CP04105A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2174\/156720508786898479","volume":"5","author":"Drago","year":"2008","journal-title":"Curr. Alzheimer Res."},{"key":"C6CP04105A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jinorgbio.2007.09.010","volume":"102","author":"Ward","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"C6CP04105A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1016\/j.bmc.2010.02.045","volume":"18","author":"Jeong","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"C6CP04105A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21063","DOI":"10.1073\/pnas.1109773109","volume":"108","author":"Li","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6CP04105A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0014-5793(95)01512-4","volume":"379","author":"Westermark","year":"1996","journal-title":"FEBS Lett."},{"key":"C6CP04105A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13505","DOI":"10.1021\/bi701427q","volume":"46","author":"Luca","year":"2007","journal-title":"Biochemistry"},{"key":"C6CP04105A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1110\/ps.036509.108","volume":"17","author":"Wiltzius","year":"2008","journal-title":"Protein Sci."},{"key":"C6CP04105A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","volume":"48","author":"Janson","year":"1999","journal-title":"Diabetes"},{"key":"C6CP04105A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2337\/db06-0734","volume":"56","author":"Ritzel","year":"2007","journal-title":"Diabetes"},{"key":"C6CP04105A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1016\/S0002-9440(10)64848-1","volume":"157","author":"Sakagashira","year":"2000","journal-title":"Am. J. Pathol."},{"key":"C6CP04105A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/jms.3338","volume":"49","author":"Bellia","year":"2014","journal-title":"J. Mass Spectrom."},{"key":"C6CP04105A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8973","DOI":"10.1021\/ja1007867","volume":"132","author":"Brender","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"C6CP04105A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6291","DOI":"10.1074\/jbc.M110.166678","volume":"286","author":"Wei","year":"2011","journal-title":"J. Biol. Chem."},{"key":"C6CP04105A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1039\/c3cc40383a","volume":"49","author":"Brender","year":"2013","journal-title":"Chem. Commun."},{"key":"C6CP04105A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jmb.2011.05.015","volume":"410","author":"Salamekh","year":"2011","journal-title":"J. Mol. Biol."},{"key":"C6CP04105A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1021\/bm501326y","volume":"16","author":"Wineman-Fisher","year":"2015","journal-title":"Biomacromolecules"},{"key":"C6CP04105A-(cit42)\/*[position()=1]","unstructured":"http:\/\/accelrys.com\/products\/discovery-studio\/"},{"key":"C6CP04105A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/jcph.1999.6201","volume":"151","author":"Kal\u00e9","year":"1999","journal-title":"J. Comput. Phys."},{"key":"C6CP04105A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"Brooks","year":"1983","journal-title":"J. Comput. Chem."},{"key":"C6CP04105A-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1021\/ja036959e","volume":"126","author":"MacKerell","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"C6CP04105A-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"key":"C6CP04105A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8910","DOI":"10.1063\/1.481505","volume":"112","author":"Mahoney","year":"2000","journal-title":"J. Chem. Phys."},{"key":"C6CP04105A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1063\/1.470117","volume":"103","author":"Essmann","year":"1995","journal-title":"J. Chem. Phys."},{"key":"C6CP04105A-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1016\/S0006-3495(95)80126-8","volume":"69","author":"Tu","year":"1995","journal-title":"Biophys. J."},{"key":"C6CP04105A-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1021\/jp973084f","volume":"102","author":"MacKerell Jr","year":"1998","journal-title":"J. Phys. Chem. B"},{"key":"C6CP04105A-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10468","DOI":"10.1021\/jp012750g","volume":"105","author":"Jungwirth","year":"2001","journal-title":"J. Phys. Chem. B"},{"key":"C6CP04105A-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/jcc.10272","volume":"24","author":"Lee","year":"2003","journal-title":"J. Comput. Chem."},{"key":"C6CP04105A-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10606","DOI":"10.1063\/1.1480013","volume":"116","author":"Lee","year":"2002","journal-title":"J. Chem. Phys."},{"key":"C6CP04105A-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.bbapap.2007.07.010","volume":"1774","author":"Patel","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"C6CP04105A-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/pro.5560070805","volume":"7","author":"Alberts","year":"1998","journal-title":"Protein science: a publication of the Protein Society"},{"key":"C6CP04105A-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1021\/ic401072d","volume":"52","author":"Laitaoja","year":"2013","journal-title":"Inorg. Chem."},{"key":"C6CP04105A-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/j.ccr.2011.12.022","volume":"256","author":"Miller","year":"2012","journal-title":"Coord. Chem. Rev."},{"key":"C6CP04105A-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1021\/cr900377t","volume":"110","author":"Miller","year":"2010","journal-title":"Chem. Rev."},{"key":"C6CP04105A-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/978-94-007-7500-8_12","volume":"13","author":"Maret","year":"2013","journal-title":"Met. Ions Life Sci."},{"key":"C6CP04105A-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.bbamem.2007.07.001","volume":"1768","author":"Brender","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"C6CP04105A-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"256954","DOI":"10.1155\/2008\/256954","volume":"2008","author":"Gilead","year":"2008","journal-title":"Exp. Diabetes Res."},{"key":"C6CP04105A-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1006\/jmbi.2001.4593","volume":"308","author":"Jaikaran","year":"2001","journal-title":"J. Mol. Biol."},{"key":"C6CP04105A-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00249-010-0623-x","volume":"40","author":"Milardi","year":"2011","journal-title":"Eur. Biophys. J."},{"key":"C6CP04105A-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S1047-8477(02)00630-5","volume":"141","author":"Scrocchi","year":"2003","journal-title":"J. Struct. Biol."}],"container-title":["Physical Chemistry Chemical Physics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/CP\/C6CP04105A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:45:31Z","timestamp":1782877531000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cp\/article\/18\/31\/21590-21599\/518074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":64,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6cp04105a","relation":{},"ISSN":["1463-9076","1463-9084"],"issn-type":[{"value":"1463-9076","type":"print"},{"value":"1463-9084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C6CP04105A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The PCCP Owner Societies have an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)","URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 13 June 2016; Accepted 6 July 2016;  Accepted Manuscript published 6 July 2016;  Advance Article published 18 July 2016;  Version of Record published 3 August 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}