{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:25:46Z","timestamp":1791858346541,"version":"4.3.4"},"reference-count":43,"publisher":"Royal Society of Chemistry (RSC)","issue":"13","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<p>Nanostraws act as direct conduits for delivering cell-impermeant materials into cells with temporal control.<\/p>","DOI":"10.1039\/c6lc00463f","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T10:33:37Z","timestamp":1464863617000},"page":"2434-2439","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Temporally resolved direct delivery of second messengers into cells using nanostraws"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-4358","authenticated-orcid":false,"given":"Alexander M.","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering"},{"name":"Stanford University"},{"name":"Stanford"},{"name":"USA"},{"name":"Chemical and Chemical Engineering Division"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry"},{"name":"Stanford University"},{"name":"Stanford"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek S.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering"},{"name":"Stanford University"},{"name":"Stanford"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Aalipour","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering"},{"name":"Stanford University"},{"name":"Stanford"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Melosh","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering"},{"name":"Stanford University"},{"name":"Stanford"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6LC00463F-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nature03681","volume":"436","author":"Collier","year":"2005","journal-title":"Nature"},{"key":"C6LC00463F-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1039\/c001196g","volume":"6","author":"Huang","year":"2010","journal-title":"Mol. BioSyst."},{"key":"C6LC00463F-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nchembio814","volume":"2","author":"Putt","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"C6LC00463F-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrm1129","volume":"4","author":"Dykxhoorn","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C6LC00463F-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrd2742","volume":"8","author":"Whitehead","year":"2009","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C6LC00463F-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"C6LC00463F-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","volume":"141","author":"Lemmon","year":"2010","journal-title":"Cell"},{"key":"C6LC00463F-(cit8)\/*[position()=1]","volume-title":"Molecular Biology of the Cell","author":"Alberts","year":"2002","unstructured":"B. Alberts , A.Johnson, J.Lewis, M.Raff, K.Roberts and P.Walter, Molecular Biology of the Cell, 4th edn, 2002"},{"key":"C6LC00463F-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1073\/pnas.081065198","volume":"98","author":"Stephens","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6LC00463F-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1369-7021(10)70105-X","volume":"13","author":"Wong","year":"2010","journal-title":"Mater. Today"},{"key":"C6LC00463F-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1007\/s00216-010-3821-6","volume":"397","author":"Kim","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"C6LC00463F-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature03556","volume":"435","author":"Urnov","year":"2005","journal-title":"Nature"},{"key":"C6LC00463F-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/nn1525","volume":"8","author":"Boyden","year":"2005","journal-title":"Nat. Neurosci."},{"key":"C6LC00463F-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/416653a","volume":"416","author":"Kuruvilla","year":"2002","journal-title":"Nature"},{"key":"C6LC00463F-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nchembio.120","volume":"4","author":"Lehar","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"C6LC00463F-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature03196","volume":"432","author":"Stockwell","year":"2004","journal-title":"Nature"},{"key":"C6LC00463F-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7753","DOI":"10.1016\/j.bmc.2010.04.084","volume":"18","author":"Warther","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"C6LC00463F-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0143-4160(93)90079-L","volume":"14","author":"Zucker","year":"1993","journal-title":"Cell Calcium"},{"key":"C6LC00463F-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.bi.45.070176.002441","volume":"45","author":"Pressman","year":"1976","journal-title":"Annu. Rev. Biochem."},{"key":"C6LC00463F-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1021\/ja071456k","volume":"129","author":"Kim","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"C6LC00463F-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1088\/0957-4484\/14\/5\/313","volume":"14","author":"McKnight","year":"2003","journal-title":"Nanotechnology"},{"key":"C6LC00463F-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1073\/pnas.0909350107","volume":"107","author":"Shalek","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6LC00463F-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1021\/nl204051v","volume":"8","author":"VanDersarl","year":"2012","journal-title":"Nano Lett."},{"key":"C6LC00463F-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/31960","volume":"392","author":"Dolmetsch","year":"1998","journal-title":"Nature"},{"key":"C6LC00463F-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1126\/science.279.5348.227","volume":"279","author":"De Koninck","year":"1998","journal-title":"Science"},{"key":"C6LC00463F-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1039\/c1lc20311h","volume":"11","author":"VanDersarl","year":"2011","journal-title":"Lab Chip"},{"key":"C6LC00463F-(cit27)\/*[position()=1]","first-page":"233103","volume":"27","author":"Christelle","year":"2015","journal-title":"J. Phys.: Condens. Matter"},{"key":"C6LC00463F-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18535","DOI":"10.1038\/srep18535","volume":"5","author":"Persson","year":"2015","journal-title":"Sci. Rep."},{"key":"C6LC00463F-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"362001","DOI":"10.1088\/0957-4484\/25\/36\/362001","volume":"25","author":"Bonde","year":"2014","journal-title":"Nanotechnology"},{"issue":"5","key":"C6LC00463F-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1038\/ncomms4613","volume":"5","author":"Xu","year":"2014","journal-title":"Nat. Commun."},{"key":"C6LC00463F-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12362","DOI":"10.1021\/la502273f","volume":"30","author":"Aalipour","year":"2014","journal-title":"Langmuir"},{"key":"C6LC00463F-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1021\/nn400874a","volume":"7","author":"Xie","year":"2013","journal-title":"ACS Nano"},{"key":"C6LC00463F-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0143-4160(85)90030-2","volume":"6","author":"Baker","year":"1985","journal-title":"Cell Calcium"},{"key":"C6LC00463F-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"C6LC00463F-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1126\/science.1465619","volume":"258","author":"Allbritton","year":"1992","journal-title":"Science"},{"key":"C6LC00463F-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1073\/pnas.96.5.2135","volume":"96","author":"Miyawaki","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6LC00463F-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/42264","volume":"388","author":"Miyawaki","year":"1997","journal-title":"Nature"},{"key":"C6LC00463F-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1039\/C3LC50566A","volume":"13","author":"Geng","year":"2013","journal-title":"Lab Chip"},{"key":"C6LC00463F-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.bmc.2009.02.043","volume":"17","author":"Faraji","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"C6LC00463F-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature12354","volume":"499","author":"Chen","year":"2013","journal-title":"Nature"},{"key":"C6LC00463F-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1054\/ceca.1999.0095","volume":"27","author":"Gee","year":"2000","journal-title":"Cell Calcium"},{"key":"C6LC00463F-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.it.2014.05.001","volume":"35","author":"Chaigne-Delalande","year":"2014","journal-title":"Trends Immunol."},{"key":"C6LC00463F-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nrm2530","volume":"9","author":"Nov\u00e1k","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/LC\/C6LC00463F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:06:39Z","timestamp":1782968799000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/16\/13\/2434-2439\/525822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":43,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6lc00463f","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C6LC00463F","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Alexander M. Xu (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4877-4358","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Alexander M. Xu (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/J-6528-2012","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 7 April 2016; Accepted 1 June 2016; Accepted Manuscript published 2 June 2016; Advance Article published 13 June 2016; Version of Record published 22 June 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}