{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:40:53Z","timestamp":1791398453615,"version":"4.3.3"},"reference-count":81,"publisher":"Royal Society of Chemistry (RSC)","issue":"14","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UH3 EB017103"],"award-info":[{"award-number":["UH3 EB017103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<p>The authors present a human liver model that supports both primary hepatocytes and human iHeps with flexibility for systems integration.<\/p>","DOI":"10.1039\/c6lc00598e","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T04:50:27Z","timestamp":1465361427000},"page":"2644-2653","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":171,"title":["Engineering a perfusable 3D human liver platform from iPS cells"],"prefix":"10.1039","volume":"16","author":[{"given":"Arnout","family":"Schepers","sequence":"first","affiliation":[{"name":"Koch Institute for Integrative Cancer Research"},{"name":"Massachusetts Institute of Technology"},{"name":"Cambridge"},{"name":"USA"},{"name":"Institute for Medical Engineering and Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheri","family":"Li","sequence":"additional","affiliation":[{"name":"Koch Institute for Integrative Cancer Research"},{"name":"Massachusetts Institute of Technology"},{"name":"Cambridge"},{"name":"USA"},{"name":"Institute for Medical Engineering and Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnav","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Koch Institute for Integrative Cancer Research"},{"name":"Massachusetts Institute of Technology"},{"name":"Cambridge"},{"name":"USA"},{"name":"Institute for Medical Engineering and Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Tschudy","family":"Seney","sequence":"additional","affiliation":[{"name":"Koch Institute for Integrative Cancer Research"},{"name":"Massachusetts Institute of Technology"},{"name":"Cambridge"},{"name":"USA"},{"name":"Institute for Medical Engineering and Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Koch Institute for Integrative Cancer Research"},{"name":"Massachusetts Institute of Technology"},{"name":"Cambridge"},{"name":"USA"},{"name":"Institute for Medical Engineering and Science"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6LC00598E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1080\/00498250701534893","volume":"37","author":"Hewitt","year":"2007","journal-title":"Xenobiotica"},{"key":"C6LC00598E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"245sr242","DOI":"10.1126\/scitranslmed.3005975","volume":"6","author":"Bhatia","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"C6LC00598E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408449209145319","volume":"22","author":"Wrighton","year":"1992","journal-title":"Crit. Rev. Toxicol."},{"key":"C6LC00598E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/096032719901800206","volume":"18","author":"Shih","year":"1999","journal-title":"Hum. Exp. Toxicol."},{"key":"C6LC00598E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1517\/17425255.2.6.875","volume":"2","author":"Martignoni","year":"2006","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"C6LC00598E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/rtph.2000.1399","volume":"32","author":"Olson","year":"2000","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"C6LC00598E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nrd1131","volume":"2","author":"Pritchard","year":"2003","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C6LC00598E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1056\/NEJMc1504317","volume":"372","author":"DiMasi","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"C6LC00598E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3109\/03602539308993982","volume":"25","author":"Wrighton","year":"1993","journal-title":"Drug Metab. Rev."},{"key":"C6LC00598E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1039\/C2TX20051A","volume":"2","author":"Soldatow","year":"2013","journal-title":"Toxicol. Res."},{"key":"C6LC00598E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1177\/1535370214531872","volume":"239","author":"Bale","year":"2014","journal-title":"Exp. Biol. Med."},{"key":"C6LC00598E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00204-012-0983-3","volume":"87","author":"Fraczek","year":"2013","journal-title":"Arch. Toxicol."},{"key":"C6LC00598E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/hep.1840040507","volume":"4","author":"Begue","year":"1984","journal-title":"Hepatology"},{"key":"C6LC00598E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1096\/fasebj.13.14.1883","volume":"13","author":"Bhatia","year":"1999","journal-title":"FASEB J."},{"issue":"Suppl 2","key":"C6LC00598E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1289\/ehp.98106511","volume":"106","author":"Guillouzo","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"C6LC00598E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/hep.20351","volume":"40","author":"Khetani","year":"2004","journal-title":"Hepatology"},{"key":"C6LC00598E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8304","DOI":"10.1016\/j.biomaterials.2012.07.068","volume":"33","author":"Yamada","year":"2012","journal-title":"Biomaterials"},{"key":"C6LC00598E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1089\/ten.tec.2008.0352","volume":"15","author":"Miranda","year":"2009","journal-title":"Tissue Eng., Part C"},{"key":"C6LC00598E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/hep.22674","volume":"49","author":"Brophy","year":"2009","journal-title":"Hepatology"},{"key":"C6LC00598E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1124\/dmd.33.1.115","volume":"33","author":"Griffin","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"C6LC00598E-(cit21)\/*[position()=1]","first-page":"209","volume":"320","author":"Vanhaecke","year":"2006","journal-title":"Methods Mol. Biol."},{"key":"C6LC00598E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1021\/bp00009a007","volume":"7","author":"Dunn","year":"1991","journal-title":"Biotechnol. Prog."},{"key":"C6LC00598E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0887-2333(01)00099-6","volume":"16","author":"Richert","year":"2002","journal-title":"Toxicol. In Vitro"},{"key":"C6LC00598E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/(SICI)1097-0290(19971220)56:6<706::AID-BIT14>3.0.CO;2-5","volume":"56","author":"Moghe","year":"1997","journal-title":"Biotechnol. Bioeng."},{"key":"C6LC00598E-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1096\/fasebj.10.13.8940293","volume":"10","author":"Berthiaume","year":"1996","journal-title":"FASEB J."},{"key":"C6LC00598E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00204-012-0968-2","volume":"87","author":"Messner","year":"2013","journal-title":"Arch. Toxicol."},{"key":"C6LC00598E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/(SICI)1097-0290(20000205)67:3<344::AID-BIT11>3.0.CO;2-2","volume":"67","author":"Glicklis","year":"2000","journal-title":"Biotechnol. Bioeng."},{"key":"C6LC00598E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2013.01.012","volume":"268","author":"Kostadinova","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"C6LC00598E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/BF02634282","volume":"31","author":"Lazar","year":"1995","journal-title":"In Vitro Cell. Dev. Biol.: Anim."},{"key":"C6LC00598E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/00498259409043224","volume":"24","author":"Koebe","year":"1994","journal-title":"Xenobiotica"},{"key":"C6LC00598E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/excr.1996.0091","volume":"223","author":"Nishikawa","year":"1996","journal-title":"Exp. Cell Res."},{"key":"C6LC00598E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrm2236","volume":"8","author":"Pampaloni","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C6LC00598E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrm1858","volume":"7","author":"Griffith","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"C6LC00598E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nbt.2989","volume":"32","author":"Bhatia","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"C6LC00598E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/bit.20086","volume":"86","author":"Glicklis","year":"2004","journal-title":"Biotechnol. Bioeng."},{"key":"C6LC00598E-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10544-006-9005-7","volume":"9","author":"Mehta","year":"2007","journal-title":"Biomed. Microdevices"},{"key":"C6LC00598E-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/039139889601900105","volume":"19","author":"Catapano","year":"1996","journal-title":"Int. J. Artif. Organs"},{"key":"C6LC00598E-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1039\/C4LC00531G","volume":"14","author":"Au","year":"2014","journal-title":"Lab Chip"},{"key":"C6LC00598E-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/bit.21360","volume":"97","author":"Lee","year":"2007","journal-title":"Biotechnol. Bioeng."},{"key":"C6LC00598E-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1039\/b614872g","volume":"7","author":"Toh","year":"2007","journal-title":"Lab Chip"},{"key":"C6LC00598E-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1039\/B913221J","volume":"10","author":"Domansky","year":"2010","journal-title":"Lab Chip"},{"key":"C6LC00598E-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1039\/c0lc00135j","volume":"10","author":"Goral","year":"2010","journal-title":"Lab Chip"},{"key":"C6LC00598E-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1039\/C4LC00071D","volume":"14","author":"Hegde","year":"2014","journal-title":"Lab Chip"},{"key":"C6LC00598E-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1039\/c3lc50197c","volume":"13","author":"Lee","year":"2013","journal-title":"Lab Chip"},{"key":"C6LC00598E-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1039\/c3lc50243k","volume":"13","author":"Wikswo","year":"2013","journal-title":"Lab Chip"},{"key":"C6LC00598E-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00204-013-1078-5","volume":"87","author":"Godoy","year":"2013","journal-title":"Arch. Toxicol."},{"key":"C6LC00598E-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nbt1361","volume":"26","author":"Khetani","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"C6LC00598E-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.23354","volume":"51","author":"Si-Tayeb","year":"2010","journal-title":"Hepatology"},{"key":"C6LC00598E-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/cr.2009.107","volume":"19","author":"Song","year":"2009","journal-title":"Cell Res."},{"key":"C6LC00598E-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5966\/sctm.2012-0160","volume":"2","author":"Ma","year":"2013","journal-title":"Stem Cells Transl. Med."},{"key":"C6LC00598E-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/embj.201387098","volume":"33","author":"Inoue","year":"2014","journal-title":"EMBO J."},{"key":"C6LC00598E-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.biotechadv.2014.01.003","volume":"32","author":"Schwartz","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"C6LC00598E-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nchembio.1270","volume":"9","author":"Shan","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"C6LC00598E-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e86372","DOI":"10.1371\/journal.pone.0086372","volume":"9","author":"Gieseck","year":"2014","journal-title":"PLoS One"},{"key":"C6LC00598E-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/hep.27621","volume":"61","author":"Berger","year":"2015","journal-title":"Hepatology"},{"key":"C6LC00598E-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.biomaterials.2012.11.029","volume":"34","author":"Takayama","year":"2013","journal-title":"Biomaterials"},{"key":"C6LC00598E-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/toxsci\/kfv048","volume":"145","author":"Ware","year":"2015","journal-title":"Toxicol. Sci."},{"key":"C6LC00598E-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1038\/ncomms2853","volume":"4","author":"Stevens","year":"2013","journal-title":"Nat. Commun."},{"key":"C6LC00598E-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1565","DOI":"10.1371\/journal.pone.0001565","volume":"3","author":"Ungrin","year":"2008","journal-title":"PLoS One"},{"key":"C6LC00598E-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1089\/ten.tea.2013.0667","volume":"20","author":"Li","year":"2014","journal-title":"Tissue Eng., Part A"},{"key":"C6LC00598E-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1039\/c0ib00054j","volume":"2","author":"Chen","year":"2010","journal-title":"Integr. Biol."},{"key":"C6LC00598E-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(75)80001-8","volume":"6","author":"Rheinwald","year":"1975","journal-title":"Cell"},{"key":"C6LC00598E-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/nprot.2011.365","volume":"6","author":"Snippert","year":"2011","journal-title":"Nat. Protoc."},{"key":"C6LC00598E-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1016\/S0142-9612(03)00340-5","volume":"24","author":"Drury","year":"2003","journal-title":"Biomaterials"},{"key":"C6LC00598E-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/00498250210128675","volume":"32","author":"Rodr\u00edguez-Antona","year":"2002","journal-title":"Xenobiotica"},{"key":"C6LC00598E-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0090-9556(24)15348-2","volume":"28","author":"Bowen","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"C6LC00598E-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2125.1989.tb03516.x","volume":"28","author":"Ged","year":"1989","journal-title":"Br. J. Clin. Pharmacol."},{"key":"C6LC00598E-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/03602530902843483","volume":"41","author":"Zhou","year":"2009","journal-title":"Drug Metab. Rev."},{"key":"C6LC00598E-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.pharmthera.2007.09.004","volume":"116","author":"Ingelman-Sundberg","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"C6LC00598E-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2217\/14622416.8.7.743","volume":"8","author":"Zanger","year":"2007","journal-title":"Pharmacogenomics"},{"key":"C6LC00598E-(cit71)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1039\/b605937f","volume":"6","author":"Di Carlo","year":"2006","journal-title":"Lab Chip"},{"key":"C6LC00598E-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nmeth.1290","volume":"6","author":"Skelley","year":"2009","journal-title":"Nat. Methods"},{"key":"C6LC00598E-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/03014460.2013.807878","volume":"40","author":"Bianconi","year":"2013","journal-title":"Ann. Hum. Biol."},{"key":"C6LC00598E-(cit74)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1188302","volume":"328","author":"Huh","year":"2010","journal-title":"Science"},{"key":"C6LC00598E-(cit75)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nmat4570","volume":"15","author":"Zhang","year":"2016","journal-title":"Nat. Mater."},{"key":"C6LC00598E-(cit76)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/bit.1071","volume":"73","author":"Tilles","year":"2001","journal-title":"Biotechnol. Bioeng."},{"key":"C6LC00598E-(cit77)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.transproceed.2012.03.007","volume":"44","author":"Noh","year":"2012","journal-title":"Transplant. Proc."},{"key":"C6LC00598E-(cit78)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature12271","volume":"499","author":"Takebe","year":"2013","journal-title":"Nature"},{"key":"C6LC00598E-(cit79)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e77673","DOI":"10.1371\/journal.pone.0077673","volume":"8","author":"Itoh","year":"2013","journal-title":"PLoS One"},{"key":"C6LC00598E-(cit80)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nmeth.2999","volume":"11","author":"Burridge","year":"2014","journal-title":"Nat. Methods"},{"key":"C6LC00598E-(cit81)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.scr.2012.06.004","volume":"9","author":"Yu","year":"2012","journal-title":"Stem Cell Res."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/LC\/C6LC00598E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:53:04Z","timestamp":1783450384000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/16\/14\/2644-2653\/525857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":81,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6lc00598e","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C6LC00598E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 5 May 2016; Accepted 7 June 2016; Accepted Manuscript published 8 June 2016; Advance Article published 14 June 2016; Version of Record published 5 July 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}