{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:28:33Z","timestamp":1773289713313,"version":"3.50.1"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/01\/COE\/08\/05"],"award-info":[{"award-number":["BT\/01\/COE\/08\/05"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"crossref","award":["BT\/01\/COE\/08\/05"],"award-info":[{"award-number":["BT\/01\/COE\/08\/05"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The pineal gland is a neuroendocrine gland located at the center of the brain. It is known to regulate various physiological functions in the body through secretion of the neurohormone melatonin. Comprehensive characterization of the human pineal gland proteome has not been undertaken to date. We employed a high-resolution mass spectrometry-based approach to characterize the proteome of the human pineal gland. A total of 5874 proteins were identified from the human pineal gland in this study. Of these, 5820 proteins were identified from the human pineal gland for the first time. Interestingly, 1136 proteins from the human pineal gland were found to contain a signal peptide domain, which indicates the secretory nature of these proteins. An unbiased global proteomic profile of this biomedically important organ should benefit molecular research to unravel the role of the pineal gland in neuropsychiatric and neurodegenerative diseases.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c6mb00507a","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:06:16Z","timestamp":1474416376000},"page":"3622-3632","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterization of human pineal gland proteome"],"prefix":"10.1093","volume":"12","author":[{"given":"Soujanya D","family":"Yelamanchi","sequence":"first","affiliation":[{"name":"School of Biotechnology, KIIT University b , Bhubaneswar 751 024, India \u00a0 ppmathur@yahoo.com"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560 066, India \u00a0 keshav@ibioinformatics.org \u00a0 soujanya@ibioinformatics.org \u00a0 manish@ibioinformatics.org \u00a0 anil@ibioinformatics.org \u00a0 lathika@ibioinformatics.org \u00a0 gourav@ibioinformatics.org \u00a0 sandip@ibioinformatics.org \u00a0 gajanan@ibioinformatics.org \u00a0 harsha@ibioinformatics.org"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Manipal University, Madhav Nagar c , Manipal 576 104, India"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560 066, India \u00a0 keshav@ibioinformatics.org \u00a0 soujanya@ibioinformatics.org \u00a0 manish@ibioinformatics.org \u00a0 anil@ibioinformatics.org \u00a0 lathika@ibioinformatics.org \u00a0 gourav@ibioinformatics.org \u00a0 sandip@ibioinformatics.org \u00a0 gajanan@ibioinformatics.org \u00a0 harsha@ibioinformatics.org"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil K","family":"Madugundu","sequence":"additional","affiliation":[{"name":"Centre for Bioinformatics, Pondicherry University d , Puducherry 605 014, India"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560 066, India \u00a0 keshav@ibioinformatics.org \u00a0 soujanya@ibioinformatics.org \u00a0 manish@ibioinformatics.org \u00a0 anil@ibioinformatics.org \u00a0 lathika@ibioinformatics.org \u00a0 gourav@ibioinformatics.org \u00a0 sandip@ibioinformatics.org \u00a0 gajanan@ibioinformatics.org \u00a0 harsha@ibioinformatics.org"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lathika","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560 066, India \u00a0 keshav@ibioinformatics.org \u00a0 soujanya@ibioinformatics.org \u00a0 manish@ibioinformatics.org \u00a0 anil@ibioinformatics.org \u00a0 lathika@ibioinformatics.org \u00a0 gourav@ibioinformatics.org \u00a0 sandip@ibioinformatics.org \u00a0 gajanan@ibioinformatics.org \u00a0 harsha@ibioinformatics.org"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gourav","family":"Dey","sequence":"additional","affiliation":[{"name":"Manipal University, Madhav Nagar c , Manipal 576 104, India"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560 066, India \u00a0 keshav@ibioinformatics.org \u00a0 soujanya@ibioinformatics.org \u00a0 manish@ibioinformatics.org \u00a0 anil@ibioinformatics.org \u00a0 lathika@ibioinformatics.org \u00a0 gourav@ibioinformatics.org \u00a0 sandip@ibioinformatics.org \u00a0 gajanan@ibioinformatics.org \u00a0 harsha@ibioinformatics.org"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandip","family":"Chavan","sequence":"additional","affiliation":[{"name":"Manipal University, Madhav Nagar c , Manipal 576 104, India"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560 066, India \u00a0 keshav@ibioinformatics.org \u00a0 soujanya@ibioinformatics.org 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Bioinformatics, Pondicherry University d , Puducherry 605 014, India"},{"name":"School of Biotechnology, KIIT University b , Bhubaneswar 751 024, India \u00a0 ppmathur@yahoo.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harsha","family":"Gowda","sequence":"additional","affiliation":[{"name":"YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University e , Mangalore 575 018, India"},{"name":"School of Biotechnology, KIIT University b , Bhubaneswar 751 024, India \u00a0 ppmathur@yahoo.com"},{"name":"Institute of Bioinformatics, International Technology Park a , Bangalore 560 066, India \u00a0 keshav@ibioinformatics.org \u00a0 soujanya@ibioinformatics.org \u00a0 manish@ibioinformatics.org \u00a0 anil@ibioinformatics.org \u00a0 lathika@ibioinformatics.org \u00a0 gourav@ibioinformatics.org \u00a0 sandip@ibioinformatics.org \u00a0 gajanan@ibioinformatics.org \u00a0 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