{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:45:38Z","timestamp":1789731938007,"version":"4.0.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Zika virus (ZIKV) is an emergent arbovirus that has attracted attention in the last year as a possible causative agent of congenital malformation; it shows a remarkably increased microcephaly risk during otherwise healthy pregnancies. We present here an analysis of all ZIKV sequences available in Genbank up to April 2016, studying the mutations in the whole polyprotein and their possible structural implications for the proteins E, NS1, NS3 and NS5. This study suggests that microcephaly is not a consequence of any particular amino acid substitution but, conceivably, is a feature of ZIKV itself. Moreover, the structural analysis of ZIKV proteins, together with the mutational landscape of ZIKV and a structure-sequence comparison with other flaviviruses, allows the suggestion of regions that could be exploited as anti-ZIKV targets, including some allosteric sites found in the NS3 and NS5 proteins of DENV.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c6mb00645k","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T08:53:39Z","timestamp":1476867219000},"page":"122-131","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of worldwide sequence mutations in Zika virus proteins E, NS1, NS3 and NS5 from a structural point of view"],"prefix":"10.1093","volume":"13","author":[{"given":"C F","family":"Baez","sequence":"first","affiliation":[{"name":"Preventive Medicine Department, Rio de Janeiro Federal University Hospital a , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V A","family":"Barel","sequence":"additional","affiliation":[{"name":"ModMolQSAR Laboratory, Faculty of Pharmaceutical Sciences, Rio de Janeiro Federal University b , Brazil \u00a0 cirauquipharma@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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Cirauqui (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4752-9916","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 9 September 2016; Accepted 19 October 2016;  Accepted Manuscript published 19 October 2016;  Advance Article published 2 November 2016;  Version of Record published 20 December 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}