{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:51:15Z","timestamp":1767927075933,"version":"3.49.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372117,81672264"],"award-info":[{"award-number":["81372117,81672264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81372117,81672264"],"award-info":[{"award-number":["81372117,81672264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ischemic arrhythmias are the main causes of sudden cardiac death. It has been reported that soluble epoxide hydrolase inhibitors (sEHis) could prevent arrhythmias; however, the underlying molecular mechanisms remain unclear. In recent years, the proarrhythmic role of microRNA-1 (miR-1) has been investigated. This study aimed to elucidate whether sEHis prevented ischemic arrhythmias by suppressing miR-1. The primary neonatal mouse ventricular myocyte model of miR-1 overexpression was established by incubating with agonist microONTM mmu-miR-1a-3p agomir (DAEDstainTM Dye) (agomiR-1). The sEHi, trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB), was administered following miR-1 overexpression. Quantitative real-time PCR (qPCR) and western blotting were used to test alterations in the expression of miR-1 and its target mRNAs GJA1 and KCNJ2 and their respective encoded proteins connexin 43 (Cx43) and the K+ channel subunit (Kir2.1). The whole-cell patch-clamp technique was used to record the alterations of the inward rectifying K+ current (IK1). Compared with the control group, miR-1 levels were significantly increased in the agomiR-1 group (p &amp;lt; 0.05), which suggested the successful construction of the miR-1 overexpression model. Compared with the control group, the levels of GJA1 and KCNJ2 mRNAs and Cx43 and Kir2.1 proteins in the agomiR-1 group were significantly decreased, and IK1 was significantly impaired (all p &amp;lt; 0.05). The miR-1 levels were dose-dependently decreased by t-AUCB, whereas t-AUCB dose-dependently increased the levels of GJA1 and KCNJ2 mRNAs and Cx43 and Kir2.1 proteins. Furthermore, t-AUCB restored the impaired IK1 (all p &amp;lt; 0.05). In conclusion, the sEHi t-AUCB has the ability to down-regulate proarrhythmic miR-1 and up-regulate its target genes and proteins, eventually restoring IK1.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c6mb00824k","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T03:27:36Z","timestamp":1483759656000},"page":"556-564","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Soluble epoxide hydrolase inhibitors might prevent ischemic arrhythmias\n                    <i>via<\/i>\n                    microRNA-1 repression in primary neonatal mouse ventricular myocytes"],"prefix":"10.1093","volume":"13","author":[{"given":"Qiong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University a , Changsha, Hunan 410011, China \u00a0 xudanyan02@163.com \u00a0 +86 731 85295407 \u00a0 +86 731 85292100"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, People's Hospital of Dongying b , Dongying, Shandong 257000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University a , Changsha, Hunan 410011, China \u00a0 xudanyan02@163.com \u00a0 +86 731 85295407 \u00a0 +86 731 85292100"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University a , Changsha, Hunan 410011, China \u00a0 xudanyan02@163.com \u00a0 +86 731 85295407 \u00a0 +86 731 85292100"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University a , Changsha, Hunan 410011, China \u00a0 xudanyan02@163.com \u00a0 +86 731 85295407 \u00a0 +86 731 85292100"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-jun","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University a , Changsha, Hunan 410011, China \u00a0 xudanyan02@163.com \u00a0 +86 731 85295407 \u00a0 +86 731 85292100"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-xiu","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University a , Changsha, Hunan 410011, China \u00a0 xudanyan02@163.com \u00a0 +86 731 85295407 \u00a0 +86 731 85292100"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan-yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University a , Changsha, Hunan 410011, China \u00a0 xudanyan02@163.com \u00a0 +86 731 85295407 \u00a0 +86 731 85292100"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,1,6]]},"reference":[{"issue":"41","key":"2026010816044095300_cit1","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","article-title":"2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC) Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)","volume":"36","author":"Priori","year":"2015","journal-title":"Eur. 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