{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:18:26Z","timestamp":1791400706965,"version":"4.3.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1061550"],"award-info":[{"award-number":["1061550"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1084927"],"award-info":[{"award-number":["1084927"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Metallomics"],"abstract":"<p>It is unclear why ubiquitous expression of mutant SOD1 selectively affects the central nervous system in amyotrophic lateral sclerosis. Here we hypothesise that the central nervous system is primarily affected because, unlike other tissues, it has relatively limited capacity to satiate an increased requirement for Cu.<\/p>","DOI":"10.1039\/c6mt00099a","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T20:23:36Z","timestamp":1466627016000},"page":"1002-1011","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS"],"prefix":"10.1093","volume":"8","author":[{"given":"J. B.","family":"Hilton","sequence":"first","affiliation":[{"name":"Department of Pathology"},{"name":"the University of Melbourne"},{"name":"Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pathology"},{"name":"the University of Melbourne"},{"name":"Victoria 3010, Australia"},{"name":"Florey Institute of Neuroscience and Mental Health"},{"name":"the University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Crouch","sequence":"additional","affiliation":[{"name":"Department of Pathology"},{"name":"the University of Melbourne"},{"name":"Victoria 3010, Australia"},{"name":"Florey Institute of Neuroscience and Mental Health"},{"name":"the University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6MT00099A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"C6MT00099A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"C6MT00099A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0896-6273(95)90259-7","volume":"14","author":"Wong","year":"1995","journal-title":"Neuron"},{"key":"C6MT00099A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s004010050650","volume":"93","author":"Dal Canto","year":"1997","journal-title":"Acta Neuropathol."},{"key":"C6MT00099A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nm1205","volume":"11","author":"Ralph","year":"2005","journal-title":"Nat. Med."},{"key":"C6MT00099A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e15445","DOI":"10.1371\/journal.pone.0015445","volume":"5","author":"Henriques","year":"2010","journal-title":"PLoS One"},{"key":"C6MT00099A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/14660820310011700","volume":"4","author":"Andersen","year":"2003","journal-title":"Amyotrophic Lateral Scler. Other Mot. Neuron Disord."},{"key":"C6MT00099A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jbior.2015.10.006","volume":"60","author":"Hayashi","year":"2016","journal-title":"Adv. Biol. Regul."},{"key":"C6MT00099A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.gene.2015.11.049","volume":"577","author":"Kaur","year":"2016","journal-title":"Gene"},{"key":"C6MT00099A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fncel.2015.00225","volume":"9","author":"Leal","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"C6MT00099A-(cit11)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.04.010","author":"Parakh","year":"2016","journal-title":"Brain Res."},{"key":"C6MT00099A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1074\/jbc.M110.186999","volume":"286","author":"Lelie","year":"2011","journal-title":"J. Biol. Chem."},{"key":"C6MT00099A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1523\/JNEUROSCI.4196-13.2014","volume":"34","author":"Roberts","year":"2014","journal-title":"J. Neurosci."},{"key":"C6MT00099A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2016.01.020","volume":"89","author":"Williams","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"C6MT00099A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1471-4159.2004.02455.x","volume":"89","author":"Li","year":"2004","journal-title":"J. Neurochem."},{"key":"C6MT00099A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"C6MT00099A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1073\/pnas.1116227108","volume":"109","author":"Donnelly","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6MT00099A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1073\/pnas.91.17.8292","volume":"91","author":"Borchelt","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6MT00099A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/abio.1994.1408","volume":"221","author":"Levenson","year":"1994","journal-title":"Anal. Biochem."},{"key":"C6MT00099A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3109\/21678421.2013.824000","volume":"14","author":"McAllum","year":"2013","journal-title":"Amyotrophic Lateral Scler. Frontotemporal Degener."},{"key":"C6MT00099A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"44035","DOI":"10.1074\/jbc.M111.274407","volume":"286","author":"Soon","year":"2011","journal-title":"J. Biol. Chem."},{"key":"C6MT00099A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1016\/S0021-9258(19)44055-6","volume":"248","author":"Forman","year":"1973","journal-title":"J. Biol. Chem."},{"key":"C6MT00099A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16525","DOI":"10.1021\/bi048831v","volume":"43","author":"Lynch","year":"2004","journal-title":"Biochemistry"},{"key":"C6MT00099A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jmb.2008.10.003","volume":"385","author":"Rumfeldt","year":"2009","journal-title":"J. Mol. Biol."},{"key":"C6MT00099A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jmb.2011.04.027","volume":"409","author":"Ip","year":"2011","journal-title":"J. Mol. Biol."},{"key":"C6MT00099A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30624","DOI":"10.1074\/jbc.M115.666503","volume":"290","author":"Chattopadhyay","year":"2015","journal-title":"J. Biol. Chem."},{"key":"C6MT00099A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.expneurol.2008.05.011","volume":"213","author":"Tokuda","year":"2008","journal-title":"Exp. Neurol."},{"key":"C6MT00099A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/path.4511","volume":"236","author":"Hodgkinson","year":"2015","journal-title":"J. Pathol."},{"key":"C6MT00099A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1021\/ar300074t","volume":"45","author":"Crouch","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"C6MT00099A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1471-4159.2009.06310.x","volume":"111","author":"Tokuda","year":"2009","journal-title":"J. Neurochem."},{"key":"C6MT00099A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.nbd.2013.01.001","volume":"54","author":"Tokuda","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"C6MT00099A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/hmg\/dds399","volume":"22","author":"Graffmo","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"C6MT00099A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1093\/hmg\/dds188","volume":"21","author":"Synofzik","year":"2012","journal-title":"Hum. Mol. Genet."}],"container-title":["Metallomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/MT\/C6MT00099A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T01:42:39Z","timestamp":1656726159000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/metallomics\/article\/8\/9\/1002-1011\/6025018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6mt00099a","relation":{},"ISSN":["1756-5901","1756-591X"],"issn-type":[{"value":"1756-5901","type":"print"},{"value":"1756-591X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is CrossCheck deposited","name":"crosscheck","explanation":{"URL":"http:\/\/www.crossref.org\/crosscheck\/index.html"},"group":{"name":"crosscheck","label":"CROSSCHECK"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)","URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Received 15 April 2016; Accepted 14 June 2016; Accepted Manuscript published 22 June 2016; Advance Article published 30 June 2016; Version of Record published 1 September 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}