{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:16:09Z","timestamp":1790702169845,"version":"4.1.0"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","issue":"46","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81225010"],"award-info":[{"award-number":["81225010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81272114"],"award-info":[{"award-number":["81272114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"DOI":"10.1039\/c6nr06872c","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T03:54:14Z","timestamp":1477454054000},"page":"19270-19279","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["5-Aminolevulinic acid loaded ethosomal vesicles with high entrapment efficiency for in vitro topical transdermal delivery and photodynamic therapy of hypertrophic scars"],"prefix":"10.1039","volume":"8","author":[{"given":"Zheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxiang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6NR06872C-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"565","DOI":"10.6061\/clinics\/2014(08)11","volume":"69","author":"Rabello","year":"2014","journal-title":"Clinics"},{"key":"C6NR06872C-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1524-4725.2008.34406.x","volume":"35","author":"Wolfram","year":"2009","journal-title":"Dermatol. Surg."},{"key":"C6NR06872C-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.bjps.2014.04.011","volume":"67","author":"Monstrey","year":"2014","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"C6NR06872C-(cit4)\/*[position()=1]","first-page":"80","author":"Juckett","year":"2009","journal-title":"Am. Fam. Physician"},{"key":"C6NR06872C-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/PRS.0000000000001626","volume":"136","author":"Chang","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"C6NR06872C-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/j.1365-2133.2004.06209.x","volume":"151","author":"Karrer","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"C6NR06872C-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12394","DOI":"10.1039\/C5NR07849K","volume":"8","author":"Zhou","year":"2016","journal-title":"Nanoscale"},{"key":"C6NR06872C-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/ced.12265","volume":"39","author":"Wang","year":"2014","journal-title":"Clin. Exp. Dermatol."},{"key":"C6NR06872C-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1562\/0031-8655(2001)074<0656:THOPAP>2.0.CO;2","volume":"74","author":"Ackroyd","year":"2001","journal-title":"Photochem. Photobiol."},{"key":"C6NR06872C-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e105173","DOI":"10.1371\/journal.pone.0105173","volume":"9","author":"Morimoto","year":"2014","journal-title":"PLoS One"},{"key":"C6NR06872C-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2003.09.002","volume":"56","author":"Lopez","year":"2004","journal-title":"Adv. Drug Delivery Rev."},{"key":"C6NR06872C-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1039\/c2nr11606e","volume":"4","author":"Pegoraro","year":"2012","journal-title":"Nanoscale"},{"key":"C6NR06872C-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/lsm.20213","volume":"37","author":"Chiu","year":"2005","journal-title":"Lasers Surg. Med."},{"key":"C6NR06872C-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1111\/j.1365-2230.2009.03279.x","volume":"34","author":"Torchia","year":"2009","journal-title":"Clin. Exp. Dermatol."},{"key":"C6NR06872C-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1365-2230.2008.02873.x","volume":"33","author":"Batchelor","year":"2008","journal-title":"Clin. Exp. Dermatol."},{"key":"C6NR06872C-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijpharm.2015.08.036","volume":"494","author":"Bragagni","year":"2015","journal-title":"Int. J. Pharm."},{"key":"C6NR06872C-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1039\/C5NR06842H","volume":"8","author":"Hou","year":"2016","journal-title":"Nanoscale"},{"key":"C6NR06872C-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ijpharm.2011.10.058","volume":"422","author":"Wang","year":"2012","journal-title":"Int. J. Pharm."},{"key":"C6NR06872C-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1166\/jbn.2013.1665","volume":"9","author":"Ji","year":"2013","journal-title":"J. Biomed. Nanotechnol."},{"key":"C6NR06872C-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1166\/jbn.2010.1135","volume":"6","author":"Fu","year":"2010","journal-title":"J. Biomed. Nanotechnol."},{"key":"C6NR06872C-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"240","DOI":"10.7150\/thno.6914","volume":"4","author":"Jin","year":"2014","journal-title":"Theranostics"},{"key":"C6NR06872C-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10671","DOI":"10.1021\/acsami.5b03087","volume":"7","author":"Ma","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C6NR06872C-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.2174\/1381612822666151216145737","volume":"22","author":"Morilla","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"C6NR06872C-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/S0142-9612(00)00063-6","volume":"21","author":"Dayan","year":"2000","journal-title":"Biomaterials"},{"key":"C6NR06872C-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1467-2494.2005.00264.x","volume":"27","author":"Choi","year":"2005","journal-title":"Int. J. Cosmet. Sci."},{"key":"C6NR06872C-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"22786","DOI":"10.3390\/ijms151222786","volume":"15","author":"Wo","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"C6NR06872C-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.1166\/jnn.2011.4741","volume":"11","author":"Wo","year":"2011","journal-title":"J. Nanosci. Nanotechnol."},{"key":"C6NR06872C-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/03639040500216170","volume":"31","author":"Kosobe","year":"2005","journal-title":"Drug Dev. Ind. Pharm."},{"key":"C6NR06872C-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2008.03.008","volume":"92","author":"Di Venosa","year":"2008","journal-title":"J. Photochem. Photobiol., B"},{"key":"C6NR06872C-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2147\/IJN.S57314","volume":"9","author":"Zhang","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"C6NR06872C-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0168-3659(99)00222-9","volume":"65","author":"Touitou","year":"2000","journal-title":"J. Controlled Release"},{"key":"C6NR06872C-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.2147\/IJN.S33048","volume":"8","author":"Romero","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"C6NR06872C-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijpharm.2008.05.010","volume":"361","author":"Qiu","year":"2008","journal-title":"Int. J. Pharm."},{"key":"C6NR06872C-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/(SICI)1097-0282(2000)57:2<85::AID-BIP5>3.0.CO;2-#","volume":"57","author":"Graham","year":"2000","journal-title":"Biopolymers"},{"key":"C6NR06872C-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.nano.2011.10.006","volume":"8","author":"Zhang","year":"2012","journal-title":"Nanomedicine"},{"key":"C6NR06872C-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7827(02)00028-0","volume":"42","author":"Bouwstra","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"C6NR06872C-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1046\/j.1365-2133.2003.05545.x","volume":"149","author":"Kunii","year":"2003","journal-title":"Br. J. Dermatol."},{"key":"C6NR06872C-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1166\/jnn.2010.2207","volume":"10","author":"Mao","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"key":"C6NR06872C-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1562\/2004-07-23-RA-244.1","volume":"81","author":"Dysart","year":"2005","journal-title":"Photochem. Photobiol."},{"key":"C6NR06872C-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1011-1344(02)00269-5","volume":"67","author":"Juzenas","year":"2002","journal-title":"J. Photochem. Photobiol., B"},{"key":"C6NR06872C-(cit41)\/*[position()=1]","first-page":"1748","volume":"27","author":"Yamamoto","year":"2012","journal-title":"Oncol. Rep."},{"key":"C6NR06872C-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3109\/09546634.2012.697987","volume":"25","author":"Li","year":"2014","journal-title":"J. Dermatol. Treat."},{"key":"C6NR06872C-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jconrel.2003.10.014","volume":"94","author":"Godin","year":"2004","journal-title":"J. Controlled Release"},{"key":"C6NR06872C-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s004410000193","volume":"301","author":"H\u00e4cker","year":"2000","journal-title":"Cell Tissue Res."},{"key":"C6NR06872C-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1016\/j.biomaterials.2011.01.032","volume":"32","author":"Huang","year":"2011","journal-title":"Biomaterials"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/NR\/C6NR06872C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:05:15Z","timestamp":1783533915000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/8\/46\/19270-19279\/529575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":45,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6nr06872c","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is CrossCheck deposited","name":"crosscheck","explanation":{"URL":"http:\/\/www.crossref.org\/crosscheck\/index.html"},"group":{"name":"crosscheck","label":"CROSSCHECK"}},{"value":"Supplementary Information","URL":"http:\/\/dx.doi.org\/10.1039\/C6NR06872C","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Received 30 August 2016; Accepted 25 October 2016; Accepted Manuscript published 26 October 2016; Advance Article published 10 November 2016; Version of Record published 24 November 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}