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Chem."],"abstract":"<p>\n                    Synthesis of the fully functionalized macrolactone core of the highly cytotoxic marine natural product callyspongiolide has been achieved\n                    <italic>via<\/italic>\n                    a\n                    <italic>Z<\/italic>\n                    -selective intramolecular H\u2013W\u2013E reaction and allylic alkylation of an activated\n                    <italic>Z<\/italic>\n                    -allylic alcohol\n                    <italic>via<\/italic>\n                    an S\n                    <sub>N<\/sub>\n                    2\u2032 fashion as key steps.\n                  <\/p>","DOI":"10.1039\/c6ob01007e","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T09:31:46Z","timestamp":1465896706000},"page":"6769-6779","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Synthetic studies of callyspongiolide: synthesis of the macrolactone core of the molecule"],"prefix":"10.1039","volume":"14","author":[{"given":"Sudhakar","family":"Athe","sequence":"first","affiliation":[{"name":"Organic and Biomolecular Chemistry Division"},{"name":"CSIR-Indian Institute of Chemical Technology"},{"name":"Hyderabad 500007"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Sharma","sequence":"additional","affiliation":[{"name":"Organic and Biomolecular Chemistry Division"},{"name":"CSIR-Indian Institute of Chemical Technology"},{"name":"Hyderabad 500007"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanakaraju","family":"Marumudi","sequence":"additional","affiliation":[{"name":"Centre for NMR & Structural Chemistry"},{"name":"CSIR-Indian Institute of Chemical Technology"},{"name":"Hyderabad 500007"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Organic and Biomolecular Chemistry Division"},{"name":"CSIR-Indian Institute of Chemical Technology"},{"name":"Hyderabad 500007"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6OB01007E-(cit1a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrd2487","volume":"8","author":"Molinski","year":"2009","journal-title":"Nat. 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