{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:46:52Z","timestamp":1791298012459,"version":"4.1.0"},"reference-count":37,"publisher":"Royal Society of Chemistry (RSC)","issue":"25","funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>A novel method for the preparation of 2-carboxyl-3-aryl quinoline derivatives from anilines, ethyl glyoxalate and enol ethers as phenylacetaldehyde surrogates is reported.<\/p>","DOI":"10.1039\/c6ob01083k","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T05:31:42Z","timestamp":1464240702000},"page":"5951-5955","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Enol ethers as carbonyl surrogates in a modification of the Povarov synthesis of 3-aryl quinolines and their anti-Toxoplasma activity"],"prefix":"10.1039","volume":"14","author":[{"given":"Carla E.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology"},{"name":"McMaster University"},{"name":"Hamilton"},{"name":"Canada L8S 4M1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"McNulty","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology"},{"name":"McMaster University"},{"name":"Hamilton"},{"name":"Canada L8S 4M1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bord\u00f3n","sequence":"additional","affiliation":[{"name":"Stanley Division of Developmental Neurovirology"},{"name":"Department of Pediatrics"},{"name":"Johns Hopkins University School of Medicine"},{"name":"Baltimore"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Yolken","sequence":"additional","affiliation":[{"name":"Stanley Division of Developmental Neurovirology"},{"name":"Department of Pediatrics"},{"name":"Johns Hopkins University School of Medicine"},{"name":"Baltimore"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Jones-Brando","sequence":"additional","affiliation":[{"name":"Stanley Division of Developmental Neurovirology"},{"name":"Department of Pediatrics"},{"name":"Johns Hopkins University School of Medicine"},{"name":"Baltimore"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6OB01083K-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejmech.2015.10.007","volume":"105","author":"Di Pietro","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"C6OB01083K-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1016\/j.bmcl.2008.10.065","volume":"18","author":"Gilbert","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C6OB01083K-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.bmcl.2008.12.097","volume":"19","author":"Mai","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C6OB01083K-(cit4a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3762\/bjoc.7.110","volume":"7","author":"Vicente-Garc\u00eda","year":"2011","journal-title":"Beilstein J. Org. Chem."},{"key":"C6OB01083K-(cit4b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1021\/ol901855b","volume":"11","author":"Majumder","year":"2009","journal-title":"Org. Lett."},{"key":"C6OB01083K-(cit4c)\/*[position()=1]","first-page":"65","author":"Feng","year":"2016","journal-title":"Synthesis"},{"key":"C6OB01083K-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1039\/C3OB41539B","volume":"12","author":"McNulty","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"C6OB01083K-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1039\/C4CC03904A","volume":"50","author":"McNulty","year":"2014","journal-title":"Chem. Commun."},{"key":"C6OB01083K-(cit5c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10015","DOI":"10.1039\/C5OB01506E","volume":"13","author":"McNulty","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"C6OB01083K-(cit6a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15936","DOI":"10.1073\/pnas.1208069109","volume":"109","author":"Doggett","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6OB01083K-(cit6b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1128\/AAC.01183-15","volume":"59","author":"Miley","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"C6OB01083K-(cit6c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1021\/jm500147k","volume":"57","author":"Nilsen","year":"2014","journal-title":"J. Med. Chem."},{"key":"C6OB01083K-(cit7a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1070\/RC1967v036n09ABEH001680","volume":"36","author":"Povarov","year":"1967","journal-title":"Russ. Chem. Rev."},{"key":"C6OB01083K-(cit7b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7935","DOI":"10.1016\/S0040-4039(01)01726-9","volume":"42","author":"Batey","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"C6OB01083K-(cit7c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.1002\/ejoc.200700288","author":"Zhou","year":"2007","journal-title":"Eur. J. Org. Chem."},{"key":"C6OB01083K-(cit7d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13070","DOI":"10.1021\/ja064676r","volume":"128","author":"Akiyama","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"C6OB01083K-(cit7e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16769","DOI":"10.1002\/chem.201503044","volume":"21","author":"Galvin","year":"2015","journal-title":"Chem. \u2013 Eur. J."},{"key":"C6OB01083K-(cit8a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/cctc.201000312","volume":"3","author":"So","year":"2011","journal-title":"ChemCatChem"},{"key":"C6OB01083K-(cit8b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10216","DOI":"10.1002\/anie.201104089","volume":"50","author":"He","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"C6OB01083K-(cit8c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4950","DOI":"10.1016\/j.tetlet.2013.07.014","volume":"54","author":"Jia","year":"2013","journal-title":"Tetrahedron Lett."},{"key":"C6OB01083K-(cit8d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1246\/cl.2005.106","volume":"34","author":"Igarashi","year":"2005","journal-title":"Chem. Lett."},{"key":"C6OB01083K-(cit8e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1134\/S1070428012050107","volume":"48","author":"Khusnutdinov","year":"2012","journal-title":"Russ. J. Org. Chem."},{"key":"C6OB01083K-(cit8f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1016\/j.tetlet.2006.02.136","volume":"47","author":"Lin","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"C6OB01083K-(cit8g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1021\/jo052004y","volume":"71","author":"Tanaka","year":"2006","journal-title":"J. Org. Chem."},{"key":"C6OB01083K-(cit8h)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1080\/00397911.2011.563022","volume":"42","author":"Guo","year":"2012","journal-title":"Synth. Commun."},{"key":"C6OB01083K-(cit9a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6150","DOI":"10.1021\/ja01555a068","volume":"80","author":"Levine","year":"1958","journal-title":"J. Am. Chem. Soc."},{"key":"C6OB01083K-(cit9b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1002\/cber.19620951026","volume":"95","author":"Wittig","year":"1962","journal-title":"Chem. Ber."},{"key":"C6OB01083K-(cit9c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0040-4020(75)80017-2","volume":"31","author":"Schlude","year":"1975","journal-title":"Tetrahedron"},{"key":"C6OB01083K-(cit9d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1021\/jo01330a018","volume":"44","author":"Kruse","year":"1979","journal-title":"J. Org. Chem."},{"key":"C6OB01083K-(cit9e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1016\/0040-4039(64)83092-6","volume":"5","author":"Coulson","year":"1964","journal-title":"Tetrahedron Lett."},{"key":"C6OB01083K-(cit9f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1002\/ejoc.201000601","author":"Das","year":"2010","journal-title":"Eur. J. Org. Chem."},{"key":"C6OB01083K-(cit10a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1016\/S0040-4039(98)00502-4","volume":"39","author":"Evans","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"C6OB01083K-(cit10b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/S0040-4039(98)00504-8","volume":"39","author":"Lam","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"C6OB01083K-(cit10c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1016\/S0040-4039(98)00503-6","volume":"39","author":"Chan","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"C6OB01083K-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0920-9964(02)00357-2","volume":"62","author":"Jones-Brando","year":"2003","journal-title":"Schizophr. Res."},{"key":"C6OB01083K-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1021\/jm901857d","volume":"53","author":"Hencken","year":"2010","journal-title":"J. Med. Chem."},{"key":"C6OB01083K-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1073\/pnas.1416611112","volume":"112","author":"Capper","year":"2015","journal-title":"Proc. Natl. Acad.\nSci. U. S. A."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/OB\/C6OB01083K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:30:43Z","timestamp":1782941443000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/14\/25\/5951-5955\/530795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":37,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6ob01083k","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C6OB01083K","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 17 May 2016; Accepted 26 May 2016;  Accepted Manuscript published 26 May 2016;  Advance Article published 3 June 2016;  Version of Record published 22 June 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}