{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:02:24Z","timestamp":1787004144187,"version":"build-2736575974"},"reference-count":61,"publisher":"Royal Society of Chemistry (RSC)","issue":"35","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>\n                    Phenolic acids and their ester derivatives show specific inhibition of beta-carbonic anhydrases from\n                    <italic>Mycobacterium tuberculosis<\/italic>\n                    , and are interesting anti-mycobacterial leads.\n                  <\/p>","DOI":"10.1039\/c6ob01477a","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T14:00:11Z","timestamp":1470751211000},"page":"8322-8330","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters: kinetic and computational investigations"],"prefix":"10.1039","volume":"14","author":[{"given":"Ylenia","family":"Cau","sequence":"first","affiliation":[{"name":"Department of Biotechnology"},{"name":"Chemistry and Pharmacy"},{"name":"University of Siena"},{"name":"I-53100 Siena"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Biotechnology"},{"name":"Chemistry and Pharmacy"},{"name":"University of Siena"},{"name":"I-53100 Siena"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Dipartimento NEUROFARBA"},{"name":"Sezione di Scienze Farmaceutiche"},{"name":"Universit\u00e0 degli Studi di Firenze"},{"name":"50019 Sesto Fiorentino (Firenze)"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Botta","sequence":"additional","affiliation":[{"name":"Department of Biotechnology"},{"name":"Chemistry and Pharmacy"},{"name":"University of Siena"},{"name":"I-53100 Siena"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6OB01477A-(cit1a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C6OB01477A-(cit1b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C6OB01477A-(cit1c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"C6OB01477A-(cit1d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.4155\/fmc.15.71","volume":"7","author":"Supuran","year":"2015","journal-title":"Future Med. Chem."},{"key":"C6OB01477A-(cit1e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1042\/BCJ20160115","volume":"473","author":"Supuran","year":"2016","journal-title":"Biochem. J."},{"key":"C6OB01477A-(cit2a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/acs.jmedchem.5b01720","volume":"59","author":"Ferraroni","year":"2016","journal-title":"J. Med. Chem."},{"key":"C6OB01477A-(cit2b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1021\/ml500470b","volume":"6","author":"Tanc","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"C6OB01477A-(cit2c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18452","DOI":"10.1021\/ja207855c","volume":"133","author":"Lopez","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C6OB01477A-(cit2d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.bmcl.2008.03.012","volume":"18","author":"Innocenti","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C6OB01477A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"84","DOI":"10.18632\/oncotarget.422","volume":"3","author":"McDonald","year":"2012","journal-title":"Oncotarget"},{"key":"C6OB01477A-(cit4a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem. Rev."},{"key":"C6OB01477A-(cit4b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1517\/13543776.2013.798648","volume":"23","author":"Monti","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"C6OB01477A-(cit4c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/med.20068","volume":"26","author":"Winum","year":"2006","journal-title":"Med. Res. Rev."},{"key":"C6OB01477A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1517\/13543776.2012.649006","volume":"22","author":"Carta","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"C6OB01477A-(cit6a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1517\/13543776.2013.742065","volume":"23","author":"Scozzafava","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"C6OB01477A-(cit6b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1517\/13543776.2012.698264","volume":"22","author":"Carta","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"C6OB01477A-(cit6c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1517\/13543776.10.5.575","volume":"10","author":"Supuran","year":"2000","journal-title":"Expert Opin. Ther. Pat."},{"key":"C6OB01477A-(cit7a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C6OB01477A-(cit7b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2174\/138161208783877848","volume":"14","author":"Winum","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"C6OB01477A-(cit7c)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1002\/9783527670383","volume-title":"Trypanosomatid Diseases: Molecular Routes to Drug Discovery","author":"Mori","year":"2013","unstructured":"M. Mori and M.Botta, Trypanosomatid Diseases: Molecular Routes to Drug Discovery, 2013, pp. 57\u201379, 10.1002\/9783527670383"},{"key":"C6OB01477A-(cit7d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1021\/acschembio.5b00337","volume":"10","author":"Mori","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"C6OB01477A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1517\/17460441.2013.795145","volume":"8","author":"De Simone","year":"2013","journal-title":"Expert Opin. Drug Discovery"},{"key":"C6OB01477A-(cit9a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.2174\/138161282212160329130153","volume":"22","author":"Mori","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"C6OB01477A-(cit9b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.2174\/138161282138151112192352","volume":"21","author":"Mori","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"C6OB01477A-(cit9c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/14756366.2011.643303","volume":"28","author":"Ekinci","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C6OB01477A-(cit9d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1747-0285.2011.01104.x","volume":"77","author":"Senturk","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"C6OB01477A-(cit9e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11030-010-9271-4","volume":"15","author":"Supuran","year":"2011","journal-title":"Mol. Diversity"},{"key":"C6OB01477A-(cit9f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1016\/j.bmc.2015.10.018","volume":"23","author":"Karioti","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"C6OB01477A-(cit9g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1021\/jm1013242","volume":"54","author":"Davis","year":"2011","journal-title":"J. Med. Chem."},{"key":"C6OB01477A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.2174\/1381612822666151211094235","volume":"22","author":"Karioti","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"C6OB01477A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/14756366.2015.1122001","volume":"31","author":"Supuran","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C6OB01477A-(cit12a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1021\/acs.jmedchem.5b00523","volume":"58","author":"Grandane","year":"2015","journal-title":"J. Med. Chem."},{"key":"C6OB01477A-(cit12b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.bmc.2016.01.019","volume":"24","author":"Lomelino","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"C6OB01477A-(cit13a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E44","DOI":"10.3390\/pathogens5020044","volume":"5","author":"Supuran","year":"2016","journal-title":"Pathogens"},{"key":"C6OB01477A-(cit13b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1517\/13543776.2013.778245","volume":"23","author":"Capasso","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"C6OB01477A-(cit13c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15184","DOI":"10.1073\/pnas.96.26.15184","volume":"96","author":"Smith","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C6OB01477A-(cit13d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.2174\/138161210793429850","volume":"16","author":"Winum","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"C6OB01477A-(cit13e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.2174\/138161210793429814","volume":"16","author":"Nishimori","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"C6OB01477A-(cit14a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1074\/jbc.M414348200","volume":"280","author":"Suarez Covarrubias","year":"2005","journal-title":"J. Biol. Chem."},{"key":"C6OB01477A-(cit14b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1074\/jbc.M510756200","volume":"281","author":"Covarrubias","year":"2006","journal-title":"J. Biol. Chem."},{"key":"C6OB01477A-(cit15a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1016\/j.bmcl.2009.10.009","volume":"19","author":"Carta","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C6OB01477A-(cit15b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1021\/jm9004016","volume":"52","author":"Guzel","year":"2009","journal-title":"J. Med. Chem."},{"key":"C6OB01477A-(cit15c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1021\/jm9003126","volume":"52","author":"Nishimori","year":"2009","journal-title":"J. Med. Chem."},{"key":"C6OB01477A-(cit15d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1021\/jm9000488","volume":"52","author":"Minakuchi","year":"2009","journal-title":"J. Med. Chem."},{"key":"C6OB01477A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7181","DOI":"10.1016\/j.bmc.2015.10.014","volume":"23","author":"Maresca","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"C6OB01477A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"C6OB01477A-(cit18a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C6OB01477A-(cit18b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.2174\/138161210793429841","volume":"16","author":"Supuran","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"C6OB01477A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1021\/ml300446a","volume":"4","author":"Mori","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"C6OB01477A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"C6OB01477A-(cit21a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1021\/ci100436p","volume":"51","author":"McGann","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"C6OB01477A-(cit21c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1021\/ci100393m","volume":"51","author":"Mori","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"C6OB01477A-(cit21d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1023\/A:1016357811882","volume":"16","author":"Wang","year":"2002","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"C6OB01477A-(cit21e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1021\/ct300418h","volume":"8","author":"Miller, 3rd","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"C6OB01477A-(cit22a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3109\/14756366.2011.650168","volume":"28","author":"Maresca","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C6OB01477A-(cit22b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3109\/14756366.2011.645539","volume":"28","author":"Maresca","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C6OB01477A-(cit22c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/14756366.2011.649269","volume":"28","author":"Supuran","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"C6OB01477A-(cit23)\/*[position()=1]","volume-title":"AMBER 14","author":"Case","year":"2014","unstructured":"D. A. Case , V.Babin, J. T.Berryman, R. M.Betz, Q.Cai, D. S.Cerutti, T. E.Cheatham, III, T. A.Darden, R. E.Duke, H.Gohlke, A. W.Goetz, S.Gusarov, N.Homeyer, P.Janowski, J.Kaus, I.Kolossv\u00e1ry, A.Kovalenko, T. S.Lee, S.LeGrand, T.Luchko, R.Luo, B.Madej, K. M.Merz, F.Paesani, D. R.Roe, A.Roitberg, C.Sagui, R.Salomon-Ferrer, G.Seabra, C. L.Simmerling, W.Smith, J.Swails, R. C.Walker, J.Wang, R. M.Wolf, X.Wu, P. A.Kollman, AMBER 14, University of California, San Francisco, 2014"},{"key":"C6OB01477A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"W537","DOI":"10.1093\/nar\/gks375","volume":"40","author":"Anandakrishnan","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"C6OB01477A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmgm.2005.12.005","volume":"25","author":"Wang","year":"2006","journal-title":"J. Mol. Graphics Modell."},{"key":"C6OB01477A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","volume":"9","author":"Roe","year":"2013","journal-title":"J. Chem. Theory Comput."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/OB\/C6OB01477A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:30:24Z","timestamp":1782941424000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/14\/35\/8322-8330\/530958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":61,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6ob01477a","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C6OB01477A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 12 July 2016; Accepted 9 August 2016; Accepted Manuscript published 9 August 2016; Advance Article published 17 August 2016; Version of Record published 1 September 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}