{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:58:28Z","timestamp":1792133908641,"version":"4.4.0"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","issue":"2","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>A new chiral chromane receptor has been synthesized with a right-sized oxyanion hole to fix zwitterionic alanine. This associate allows the enantioselective extraction of this amino acid from water to chloroform.<\/p>","DOI":"10.1039\/c6ob02237e","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T06:00:49Z","timestamp":1480485649000},"page":"477-485","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A molecular receptor selective for zwitterionic alanine"],"prefix":"10.1039","volume":"15","author":[{"given":"Omayra H.","family":"Rubio","sequence":"first","affiliation":[{"name":"Organic Chemistry Department"},{"name":"University of Salamanca"},{"name":"37008 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Taouil","sequence":"additional","affiliation":[{"name":"Organic Chemistry Department"},{"name":"University of Salamanca"},{"name":"37008 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco M.","family":"Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry"},{"name":"Faculty of Chemical Sciences"},{"name":"University of Concepci\u00f3n"},{"name":"Concepci\u00f3n"},{"name":"Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Monle\u00f3n","sequence":"additional","affiliation":[{"name":"Organic Chemistry Department"},{"name":"University of Salamanca"},{"name":"37008 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3781-0803","authenticated-orcid":false,"given":"Luis","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Engineering Chemistry Department"},{"name":"University of Salamanca"},{"name":"37008 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Sanz","sequence":"additional","affiliation":[{"name":"X-Ray Diffraction Service"},{"name":"University of Salamanca"},{"name":"37008 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn R.","family":"Mor\u00e1n","sequence":"additional","affiliation":[{"name":"Organic Chemistry Department"},{"name":"University of Salamanca"},{"name":"37008 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2017]]},"reference":[{"key":"C6OB02237E-(cit1a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24499","DOI":"10.1039\/C5RA00017C","volume":"5","author":"Ghosh","year":"2015","journal-title":"RSC Adv."},{"key":"C6OB02237E-(cit1b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jms.3750","volume":"51","author":"Fujihara","year":"2016","journal-title":"J. Mass Spectrom."},{"key":"C6OB02237E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10847-015-0579-7","volume":"84","author":"Bozkurt","year":"2016","journal-title":"J. Inclusion Phenom. Macrocyclic Chem."},{"key":"C6OB02237E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.1039\/c3cs60069f","volume":"42","author":"Schneider","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"C6OB02237E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tet.2013.11.010","volume":"70","author":"Kataev","year":"2014","journal-title":"Tetrahedron"},{"key":"C6OB02237E-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5853","DOI":"10.1016\/S0040-4039(01)01100-5","volume":"42","author":"P\u00e9rez","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"C6OB02237E-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1039\/b203054c","volume":"2","author":"Oliva","year":"2002","journal-title":"J. Chem. Soc., Perkin Trans. 2"},{"key":"C6OB02237E-(cit5c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6983","DOI":"10.1016\/S0040-4039(03)01795-7","volume":"44","author":"Hern\u00e1ndez","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"C6OB02237E-(cit5d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1039\/B312560B","author":"Oliva","year":"2004","journal-title":"Chem. Commun."},{"key":"C6OB02237E-(cit5e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1021\/jo049113h","volume":"69","author":"Oliva","year":"2004","journal-title":"J. Org. Chem."},{"key":"C6OB02237E-(cit5f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1021\/ol049933g","volume":"6","author":"Oliva","year":"2004","journal-title":"Org. Lett."},{"key":"C6OB02237E-(cit5g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1016\/j.tet.2004.03.015","volume":"60","author":"Oliva","year":"2004","journal-title":"Tetrahedron"},{"key":"C6OB02237E-(cit5h)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1016\/j.tetlet.2004.04.168","volume":"45","author":"Hern\u00e1ndez","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"C6OB02237E-(cit5i)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1039\/C4OB01954G","volume":"13","author":"Fuentes de Arriba","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"C6OB02237E-(cit5j)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/ejoc.201501457","author":"de Juan Fern\u00e1ndez","year":"2016","journal-title":"Eur. J. Org. Chem."},{"key":"C6OB02237E-(cit6a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1042\/bj0271257","volume":"27","author":"Easson","year":"1933","journal-title":"J. Biochem."},{"key":"C6OB02237E-(cit6b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/162963b0","volume":"162","author":"Ogston","year":"1948","journal-title":"Nature"},{"key":"C6OB02237E-(cit6c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/(SICI)1520-636X(1997)9:2<99::AID-CHIR3>3.0.CO;2-B","volume":"9","author":"Vadim","year":"1997","journal-title":"Chirality"},{"key":"C6OB02237E-(cit7a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1039\/b822552b","volume":"39","author":"Amendola","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"C6OB02237E-(cit7b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"26568","DOI":"10.1039\/C6RA00268D","volume":"6","author":"Dey","year":"2016","journal-title":"RSC Adv."},{"key":"C6OB02237E-(cit8a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1021\/ja00030a074","volume":"114","author":"Gal\u00e1n","year":"1992","journal-title":"J. Am. Chem. Soc."},{"key":"C6OB02237E-(cit8b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1021\/jo951436d","volume":"61","author":"Metzger","year":"1996","journal-title":"J. Org. Chem."},{"key":"C6OB02237E-(cit8c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1039\/b009215k","author":"Lawless","year":"2001","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"C6OB02237E-(cit8d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/60100021","volume":"6","author":"Tamminen","year":"2001","journal-title":"Molecules"},{"key":"C6OB02237E-(cit8e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1016\/S0040-4039(01)01549-0","volume":"42","author":"Tsukube","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"C6OB02237E-(cit8f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1039\/b009041g","author":"Fitzmaurice","year":"2002","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"C6OB02237E-(cit8g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.tet.2003.11.019","volume":"60","author":"Escuder","year":"2004","journal-title":"Tetrahedron"},{"key":"C6OB02237E-(cit8h)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.1002\/352760572X","volume-title":"Functional synthetic receptors","author":"Schrader","year":"2005","unstructured":"T. Schrader and A. D.Hamilton, Functional synthetic receptors, Wiley-VCH, 2005"},{"key":"C6OB02237E-(cit8i)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.molstruc.2005.05.043","volume":"752","author":"Moghimi","year":"2005","journal-title":"J. Mol. Struct."},{"key":"C6OB02237E-(cit8j)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.tet.2007.10.066","volume":"64","author":"Costero","year":"2008","journal-title":"Tetrahedron"},{"key":"C6OB02237E-(cit8k)\/*[position()=1]","first-page":"505","volume":"88","author":"Raizada","year":"2011","journal-title":"J. Indian Chem. Soc."},{"key":"C6OB02237E-(cit8l)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3762\/bjoc.6.32","volume":"6","author":"Sp\u00e4th","year":"2010","journal-title":"Beilstein J. Org. Chem."},{"key":"C6OB02237E-(cit8m)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.1016\/j.tet.2012.03.110","volume":"68","author":"Bernier","year":"2012","journal-title":"Tetrahedron"},{"key":"C6OB02237E-(cit8n)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1021\/jp405027s","volume":"117","author":"Avil\u00e9s-Moreno","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"C6OB02237E-(cit8o)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1039\/C5OB00348B","volume":"13","author":"Mendoza","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"C6OB02237E-(cit8p)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1021\/acs.inorgchem.6b00132","volume":"55","author":"Karbarz","year":"2016","journal-title":"Inorg. Chem."},{"key":"C6OB02237E-(cit9a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1021\/ja00288a029","volume":"107","author":"Lein","year":"1985","journal-title":"J. Am. Chem. Soc."},{"key":"C6OB02237E-(cit9b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1021\/jo00376a021","volume":"51","author":"Schmidtchen","year":"1986","journal-title":"J. Org. Chem."},{"key":"C6OB02237E-(cit9c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/3-540-58800-0_19","volume":"175","author":"Seel","year":"1995","journal-title":"Top. Curr. Chem."},{"key":"C6OB02237E-(cit9d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/jlac.199619960615","volume":"6","author":"Barboiu","year":"1996","journal-title":"Liebigs Ann. Chem."},{"key":"C6OB02237E-(cit9e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11208","DOI":"10.1021\/ja982435g","volume":"120","author":"Hossain","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"C6OB02237E-(cit9f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9221","DOI":"10.1016\/S0040-4020(99)00478-0","volume":"55","author":"Barboiu","year":"1999","journal-title":"Tetrahedron"},{"key":"C6OB02237E-(cit9g)\/*[position()=1]","volume-title":"Principles and Methods in Supramolecular Chemistry","author":"Schneider","year":"2000","unstructured":"H.-J. Schneider and A.Yatsimirsky, Principles and Methods in Supramolecular Chemistry, John Wiley & Sons, Ltd., Chichester, 2000"},{"key":"C6OB02237E-(cit9h)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.1016\/S0040-4039(02)01618-0","volume":"43","author":"Sasaki","year":"2002","journal-title":"Tetrahedron Lett."},{"key":"C6OB02237E-(cit9i)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1016\/S0040-4020(03)00478-2","volume":"59","author":"Tsubaki","year":"2003","journal-title":"Tetrahedron"},{"key":"C6OB02237E-(cit9j)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nchem.352","volume":"1","author":"Weimann","year":"2009","journal-title":"Nat. Chem."},{"key":"C6OB02237E-(cit9k)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.tet.2010.01.028","volume":"66","author":"Sp\u00e4th","year":"2010","journal-title":"Tetrahedron"},{"key":"C6OB02237E-(cit9l)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tet.2012.10.020","volume":"69","author":"Karakaplan","year":"2013","journal-title":"Tetrahedron"},{"key":"C6OB02237E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1016\/S0021-9258(19)84942-6","volume":"264","author":"Shalwitz","year":"1989","journal-title":"J. Biol. Chem."},{"key":"C6OB02237E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1172\/JCI106716","volume":"50","author":"M\u00fcller","year":"2001","journal-title":"J. Clin. Invest."},{"key":"C6OB02237E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1519\/JSC.0b013e3181d82f8b","volume":"24","author":"Walter","year":"2010","journal-title":"J. Strength Cond. Res."},{"key":"C6OB02237E-(cit13)\/*[position()=1]","author":"Frisch","year":"2009","journal-title":"Gaussian 09"},{"key":"C6OB02237E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1021\/jo00987a028","volume":"38","author":"Eaton","year":"1973","journal-title":"J. Org. Chem."},{"key":"C6OB02237E-(cit15a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1039\/C5OB02387D","volume":"14","author":"Temprano","year":"2016","journal-title":"Biomol. Chem."},{"key":"C6OB02237E-(cit15b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1039\/C6OB00490C","volume":"14","author":"G\u00f3mez Herrero","year":"2016","journal-title":"Org. Biomol. Chem."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2017\/OB\/C6OB02237E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:35:37Z","timestamp":1783532137000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/15\/2\/477-485\/531276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1039\/c6ob02237e","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C6OB02237E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Crystal Structure Data","URL":"http:\/\/xlink.rsc.org?ccdc=true&msid=C6OB02237E","name":"related_data"},{"value":"Luis Sim\u00f3n (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-3781-0803","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Luis Sim\u00f3n (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/A-1553-2009","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 13 October 2016; Accepted 30 November 2016; Accepted Manuscript published 30 November 2016; Advance Article published 8 December 2016; Version of Record published 4 January 2017","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}