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Sci."],"abstract":"<p>\n                    Building from tryptophan to the tryptophan-containing HIV Nucleocapsid 7 (HIVNCp7) protein we combine biophysical and computational studies to enhance stacking interactions of purines through platination. The incorporation into a weak Lewis acid electrophile, [Pt(dien)(Nucleobase)]\n                    <sup>2+<\/sup>\n                    may lead to disruption of the HIVNCp7-RNA interaction.\n                  <\/p>","DOI":"10.1039\/c6sc03445d","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T09:46:30Z","timestamp":1475747190000},"page":"1269-1281","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Enhancement of the physicochemical properties of [Pt(dien)(nucleobase)]\n                    <sup>2+<\/sup>\n                    for HIVNCp7 targeting"],"prefix":"10.1039","volume":"8","author":[{"given":"S. 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This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)","URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 3 August 2016; Accepted 6 October 2016;  Accepted Manuscript published 6 October 2016;  Advance Article published 14 October 2016;  Version of Record published 30 January 2017","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}