{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:26:23Z","timestamp":1772166383925,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81473001"],"award-info":[{"award-number":["81473001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81573177"],"award-info":[{"award-number":["81573177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Toxicol. Res."],"abstract":"<p>Cadmium (Cd) and its compounds are well-known human carcinogens, but the mechanisms underlying the carcinogenesis are not well understood.<\/p>","DOI":"10.1039\/c6tx00433d","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T08:24:52Z","timestamp":1489739092000},"page":"361-371","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["LncRNA-MALAT1 as a novel biomarker of cadmium toxicity regulates cell proliferation and apoptosis"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-3478","authenticated-orcid":false,"given":"Qinhai","family":"Huang","sequence":"first","affiliation":[{"name":"School of Public Health"},{"name":"Guangzhou Medical University"},{"name":"Guangzhou 510182"},{"name":"People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Lu","sequence":"additional","affiliation":[{"name":"Shenzhen Longgang District Center for Disease Control and Prevention"},{"name":"Shenzhen 518172"},{"name":"P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health"},{"name":"Guangzhou Medical University"},{"name":"Guangzhou 510182"},{"name":"People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanyu","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Public Health"},{"name":"Guangzhou Medical University"},{"name":"Guangzhou 510182"},{"name":"People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health"},{"name":"Guangzhou Medical University"},{"name":"Guangzhou 510182"},{"name":"People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Harvard Medical School"},{"name":"Boston"},{"name":"USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiong","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Public Health"},{"name":"Guangzhou Medical University"},{"name":"Guangzhou 510182"},{"name":"People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017]]},"reference":[{"key":"C6TX00433D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mrfmmm.2003.07.011","volume":"533","author":"Waalkes","year":"2003","journal-title":"Mutat. Res."},{"key":"C6TX00433D-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0378-4274(02)00381-8","volume":"137","author":"Satarug","year":"2003","journal-title":"Toxicol. Lett."},{"key":"C6TX00433D-(cit3)\/*[position()=1]","first-page":"1217","volume":"93","author":"Swaddiwudhipong","year":"2010","journal-title":"J. Med. Assoc. Thailand"},{"key":"C6TX00433D-(cit4)\/*[position()=1]","first-page":"1","volume":"20","author":"Koyu","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"C6TX00433D-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1579\/0044-7447-31.6.478","volume":"31","author":"Nordberg","year":"2002","journal-title":"Ambio"},{"key":"C6TX00433D-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12011-010-8636-y","volume":"134","author":"Sch\u00f6pfer","year":"2010","journal-title":"Biol. Trace Elem. Res."},{"key":"C6TX00433D-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1093\/jxb\/err046","volume":"62","author":"Yanfei","year":"2011","journal-title":"J. Exp. Bot."},{"key":"C6TX00433D-(cit9)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"15293","DOI":"10.1038\/srep15293","volume":"5","author":"Zhou","year":"2015","journal-title":"Sci. Rep."},{"key":"C6TX00433D-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","volume":"81","author":"Rinn","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"C6TX00433D-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s00335-008-9136-7","volume":"19","author":"Amaral","year":"2008","journal-title":"Mamm. Genome"},{"key":"C6TX00433D-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature07672","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature"},{"key":"C6TX00433D-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature10398","volume":"477","author":"Guttman","year":"2011","journal-title":"Nature"},{"key":"C6TX00433D-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/ng.848","volume":"43","author":"Hung","year":"2011","journal-title":"Nat. Genet."},{"key":"C6TX00433D-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nature09819","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"C6TX00433D-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","volume":"43","author":"Wang","year":"2011","journal-title":"Mol. Cell"},{"key":"C6TX00433D-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","volume":"129","author":"Rinn","year":"2007","journal-title":"Cell"},{"key":"C6TX00433D-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.1163802","volume":"322","author":"Nagano","year":"2008","journal-title":"Science"},{"key":"C6TX00433D-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cell.2010.09.001","volume":"143","author":"Orom","year":"2010","journal-title":"Cell"},{"key":"C6TX00433D-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/onc.2010.568","volume":"30","author":"Kotake","year":"2011","journal-title":"Oncogene"},{"key":"C6TX00433D-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2010.06.040","volume":"142","author":"Huarte","year":"2010","journal-title":"Cell"},{"issue":"39","key":"C6TX00433D-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1038\/sj.onc.1206928","volume":"22","author":"Ji","year":"2003","journal-title":"Oncogene"},{"issue":"5","key":"C6TX00433D-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cell.2008.10.012","volume":"135","author":"Wilusz","year":"2008","journal-title":"Cell"},{"issue":"6","key":"C6TX00433D-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.molcel.2010.08.011","volume":"39","author":"Tripathi","year":"2010","journal-title":"Mol. Cell"},{"issue":"21","key":"C6TX00433D-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1101\/gad.204438.112","volume":"26","author":"Wilusz","year":"2012","journal-title":"Genes Dev."},{"issue":"12","key":"C6TX00433D-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1097\/JTO.0b013e3182307eac","volume":"6","author":"Schmidt","year":"2011","journal-title":"J. Thorac. Oncol."},{"issue":"7","key":"C6TX00433D-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00109-013-1028-y","volume":"91","author":"Gutschner","year":"2013","journal-title":"J. Mol. Med."},{"issue":"3","key":"C6TX00433D-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1003368","DOI":"10.1371\/journal.pgen.1003368","volume":"9","author":"Tripathi","year":"2013","journal-title":"PLoS Genet."},{"key":"C6TX00433D-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0895-3988(08)60051-3","volume":"21","author":"Lei","year":"2008","journal-title":"Biomed. Environ. Sci."},{"key":"C6TX00433D-(cit30)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"5182","DOI":"10.3390\/ijms14035182","volume":"14","author":"Qian","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"C6TX00433D-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrc1799","volume":"6","author":"Baylin","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"C6TX00433D-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/mutage\/gel068","volume":"22","author":"Herceg","year":"2007","journal-title":"Mutagenesis"},{"key":"C6TX00433D-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2164-8-39","volume":"8","author":"Hutchinson","year":"2007","journal-title":"BMC Genomics"},{"issue":"6","key":"C6TX00433D-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/sj.onc.1209846","volume":"26","author":"Lin","year":"2007","journal-title":"Oncogene"},{"key":"C6TX00433D-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2164-8-39","volume":"8","author":"Hutchinson","year":"2007","journal-title":"BMC Genomics"},{"issue":"3","key":"C6TX00433D-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1158\/0008-5472.CAN-12-2850","volume":"73","author":"Gutschner","year":"2013","journal-title":"Cancer Res."},{"issue":"6","key":"C6TX00433D-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/sj.onc.1209846","volume":"26","author":"Lin","year":"2007","journal-title":"Oncogene"},{"issue":"11","key":"C6TX00433D-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/molehr\/gap071","volume":"15","author":"Tseng","year":"2009","journal-title":"Mol. Hum. Reprod."},{"key":"C6TX00433D-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"421821","DOI":"10.1155\/2013\/421821","volume":"2013","author":"Kamran","year":"2013","journal-title":"Biomed. Res. Int."},{"issue":"6","key":"C6TX00433D-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tcm.2008.11.003","volume":"18","author":"Kume","year":"2008","journal-title":"Trends Cardiovasc. Med."},{"key":"C6TX00433D-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/sj.bjc.6603520","volume":"96","author":"Lo","year":"2007","journal-title":"Br. J. Cancer"},{"issue":"6","key":"C6TX00433D-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1046\/j.1471-4159.2000.0752227.x","volume":"75","author":"Bottner","year":"2000","journal-title":"J. Neurochem."},{"key":"C6TX00433D-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/toxsci\/kfp233","volume":"112","author":"Thomas","year":"2009","journal-title":"Toxicol. Sci."},{"issue":"3","key":"C6TX00433D-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.toxlet.2014.01.012","volume":"225","author":"Weng","year":"2014","journal-title":"Toxicol. Lett."},{"key":"C6TX00433D-(cit45)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fpls.2012.00105","volume":"3","author":"Mendoza-Soto","year":"2012","journal-title":"Front. Plant Sci."},{"key":"C6TX00433D-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0895-3988(10)60045-1","volume":"23","author":"Lei","year":"2010","journal-title":"Biomed. Environ. Sci."},{"key":"C6TX00433D-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00420-010-0527-1","volume":"84","author":"Ikeda","year":"2011","journal-title":"Int. Arch. Occup. Environ. Health"}],"container-title":["Toxicology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2017\/TX\/C6TX00433D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T15:29:44Z","timestamp":1577978984000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxres\/article\/6\/3\/361-371\/5567301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1039\/c6tx00433d","relation":{},"ISSN":["2045-452X","2045-4538"],"issn-type":[{"value":"2045-452X","type":"print"},{"value":"2045-4538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Qinhai Huang (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-0141-3478","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 26 November 2016; Accepted 13 March 2017;  Accepted Manuscript published 17 March 2017;  Advance Article published 4 April 2017;  Version of Record published 9 May 2017","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}